18 citations
,
March 2020 in “Frontiers in Neuroendocrinology” The enzymes 5α-reductase and 3α/β-hydroxysteroid oxidoreductase help create brain-active substances from progesterone and testosterone, which could be used for treatment, but more research is needed to ensure their safety and effectiveness.
December 2023 in “International Journal of Molecular Sciences” Men with early balding showed higher levels of certain genes linked to hair loss and possibly prostate cancer.
21 citations
,
January 2020 in “General and Comparative Endocrinology” Lack or blocking of SRD5a, a key component in hormone creation, can lead to conditions like pseudohermaphrodism and affect hair growth, bone mass, muscle strength, and reproductive health. More research is needed on its regulation from fertilization to adulthood.
36 citations
,
October 2009 in “Journal of biological chemistry/The Journal of biological chemistry” Two new compounds were found to build bone and muscle without affecting reproductive organs and skin oil glands.
1 citations
,
April 2022 in “Applied sciences” Bitter melon extract may help prevent hair loss and can be used in cosmetic products.
11 citations
,
August 2020 in “Diabetes” Testosterone helps human pancreatic cells increase insulin release.
January 2019 in “International Journal of Plant Animal and Environmental Sciences” The extract from marine green alga Chlamydomonas sp. W80 has antioxidant, anti-inflammatory, anti-aging, hair growth, immune-boosting, and skin lightening effects.
January 2022 in “Food Science and Technology” The herbal mixture could potentially improve hair loss.
4 citations
,
September 2006 in “European Urology Supplements” Dutasteride reduces DHT and improves BPH symptoms more effectively than finasteride.
30 citations
,
December 1999 in “Journal of Investigative Dermatology Symposium Proceedings” Steroids, particularly estrogens and 5α-reductase inhibitors, affect blood vessel-related hair growth processes in hair follicle cells.
10 citations
,
June 2019 in “International Journal of Cosmetic Science” Some plant-based chemicals may help with hair growth, but more research is needed to confirm their effectiveness.
14 citations
,
November 2012 in “SLAS discovery” Some herbal extracts can promote hair growth and prevent hair loss.
27 citations
,
May 2017 in “Marine Drugs” Undariopsis peterseniana extract helps hair grow by activating certain cell growth pathways and could be a new treatment for hair loss.
7 citations
,
May 2015 in “Journal of The American Academy of Dermatology” Finasteride helps treat frontal fibrosing alopecia, improving or stabilizing the condition in many patients.
5 citations
,
November 2015 in “Journal of Enzyme Inhibition and Medicinal Chemistry” Certain derivatives are more effective 5α-reductase type 2 inhibitors than finasteride.
47 citations
,
August 2000 in “Endocrine Reviews” The document concludes that more research is needed to understand excessive hair growth in women with normal hormone levels and regular ovulation.
39 citations
,
September 2013 in “Journal of Cosmetic Dermatology” Herbs can potentially treat hair loss by inhibiting a key enzyme and promoting hair growth, and deficiencies in zinc, biotin, and iron are linked to hair loss.
17 citations
,
April 2021 in “Clinical Phytoscience” Chitrak is a medicinal plant with health benefits like fighting microbes, reducing inflammation, and promoting hair growth, but it can be toxic and needs more research.
12 citations
,
October 1995 in “The Journal of Clinical Endocrinology & Metabolism” Skin changes can indicate hormonal imbalances and help diagnose endocrine disorders.
3 citations
,
April 2010 in “Endocrinology” The mouse model suggests male pattern baldness may be due to an enzyme increasing DHT and higher androgen receptor levels in hair follicles.
August 1993 in “Journal of Dermatological Science” Testosterone metabolism in balding scalp cells may not be the main cause of hair loss.
17 citations
,
December 2004 in “The Journal of Men's Health & Gender” Male pattern baldness involves hormone-related hair thinning, shorter hair, and inflammation.
November 2023 in “Research Square (Research Square)” Finasteride affects the male rat brain by reducing certain protein activation, but these effects may reverse after stopping the drug.
January 2006 in “The Journal of Korean Medicine Ophthalmology and Otolaryngology and Dermatology” Rubus coreanum may help hair growth but not through the tested mechanisms, and none of the herbal extracts help with acne.
59 citations
,
March 2020 in “Journal of Biomedical Science” Understanding how hair follicle stem cells work can help find new ways to prevent hair loss and promote hair growth.
1 citations
,
January 2018 in “AUSTRALIAN JOURNAL OF BASIC AND APPLIED SCIENCES” Zapoteca portoricensis extract may help protect against prostate issues and support liver and kidney health in rats.
39 citations
,
August 2004 in “International journal of gynaecology and obstetrics” Finasteride and CPA-EE2 equally reduce hirsutism, but affect hormone levels differently.
2 citations
,
April 2017 in “Actas Dermo-Sifiliográficas” Best treatment for Frontal Fibrosing Alopecia is 5-alpha-reductase inhibitors and intralesional corticosteroids.
8 citations
,
May 2017 in “Current traditional medicine” Stinging nettle has compounds that help with joint pain, arthritis, and prostate issues.
4 citations
,
April 1999 in “Dermatologic Clinics” Androgens, like DHT, affect hair growth and treatments like finasteride may help.