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research Finasteride, a 5alpha-reductase inhibitor, potentiates antinociceptive effects of morphine, prevents the development of morphine tolerance and attenuates abstinence behavior in the rat

4 citations , April 2009 in “Journal of Pain”

Finasteride boosts morphine's pain relief and prevents tolerance and withdrawal in rats.

Inhibitory Effects of Pueraria Mirifica Aqueous Extracts on 5α-Reductase and Prostate Histomorphometry in Testosterone-Induced Benign Prostatic Hyperplasia Sprague Dawley Rats

research Inhibitory Effects of Pueraria mirifica Aqueous Extracts on 5α-reductase and Prostate Histomorphometry in Testosterone-induced Benign Prostatic Hyperplasia Sprague Dawley Rats

August 2023 in “Malaysian Journal of Medicine and Health Sciences/Malaysian journal of medicine and health sciences”

Pueraria mirifica extract may help treat benign prostatic hyperplasia.

research Finasteride, a 5alpha-reductase enzyme inhibitor, alone and synergism with a neurosteroid reduces responsiveness to nociceptive stimuli in male rat

April 2009 in “Journal of Pain”

Finasteride reduces pain in male rats and works better with testosterone.

research External genitalia abnormalities in male rats exposed in utero to finasteride, a 5α-reductase inhibitor

122 citations , July 1990 in “Teratology”

Finasteride exposure in pregnancy causes genital abnormalities in male rats.

Persistent Erectile Dysfunction in Men Exposed to 5α-Reductase Inhibitors, Finasteride, or Dutasteride

research Persistent erectile dysfunction in men exposed to the 5α-reductase inhibitors, finasteride, or dutasteride

50 citations , March 2017 in “PeerJ”

Using finasteride or dutasteride may cause long-lasting erectile dysfunction.

research Leydig Cell Hyperplasia and Adenomas in Mice Treated with Finasteride, a 5α-Reductase Inhibitor: A Possible Mechanism

35 citations , February 1994 in “Fundamental and applied toxicology”

High doses of finasteride cause cell growth and tumors in mice.

research Reversible decreases of fertility in male Sprague-Dawley rats treated orally with finasteride, a 5α-reductase inhibitor

28 citations , January 1991 in “Reproductive Toxicology”

Finasteride temporarily lowers male rat fertility without affecting libido.

research Finasteride: The First 5α-Reductase Inhibitor

23 citations , July 1993 in “Pharmacotherapy”

Finasteride treats enlarged prostate and baldness, but may cause limited urinary improvement and sex-related side effects.

research Synthesis and activity of 8-substituted benzo[c]quinolizin-3-ones as dual inhibitors of human 5α-reductases 1 and 2

9 citations , November 2004 in “Bioorganic & Medicinal Chemistry Letters”

New compounds were made that effectively block enzymes related to prostate issues and hair loss.

Pumpkin Seed Oil-Loaded Niosomes for Topical Application: 5α-Reductase Inhibitory, Anti-Inflammatory, and Anti-Hair Loss Effects

research Pumpkin Seed Oil-Loaded Niosomes for Topical Application: 5α-Reductase Inhibitory, Anti-Inflammatory, and In Vivo Anti-Hair Loss Effects

7 citations , July 2022 in “Pharmaceuticals”

Pumpkin Seed Oil in niosomes may help treat hair loss and improve hair growth.

research Cyclohex-1-ene Carboxylic Acids: Synthesis and Biological Evaluation of Novel Inhibitors of Human 5α Reductase

6 citations , March 2003 in “Archiv Der Pharmazie”

Scientists made new substances that can block an enzyme linked to prostate issues and hair loss, with potential for creating a new treatment.

Intraoperative Iris Behavior During Phacoemulsification Maneuvers in Rabbits Treated with Selective Alpha-1 Blocker, 5-Alpha-Reductase Inhibitor, or Anxiolytic Medication

research Intraoperative Iris Behavior during Phacoemulsification Maneuvers in Rabbits Treated with Selective α1-Blocker, 5α-Reductase Inhibitor, or Anxiolytic Medication

August 2024 in “Journal of Personalized Medicine”

Tamsulosin increases the risk of floppy iris during eye surgery.

research Synthesis of avicequinone c and analogs toward the study of 5α-reductase inhibitory activity

January 2015

2-Hydroxy-1,4-naphthoquinone is a strong 5α-reductase inhibitor.

research Carica papaya Flower Extracts Possess Antioxidant and 5α-reductase Inhibitory Activities

January 2023 in “Acta medica Philippina”

Papaya flower extract may help with hair growth by blocking a hair loss enzyme and acting as an antioxidant.

Synthesis of Phenanthridin-3-One Derivatives: Non-Steroidal Inhibitors of Steroid 5-Alpha-Reductase

research Synthesis of phenanthridin-3-one derivatives: Non-steroidal inhibitors of steroid 5-α-reductase

20 citations , June 1995 in “Tetrahedron Letters”

New chemicals were made that can block an enzyme linked to hair loss, prostate growth, and acne.

research Topical MK-386 (M), an inhibitor of 5α-reductase (5αr) type I, suppresses sebum dht.

February 1996 in “Clinical Pharmacology & Therapeutics”

MK-386 reduces sebum DHT levels.

Treatment of Male Rats with Finasteride, an Inhibitor of 5alpha-Reductase Enzyme, Induces Long-Lasting Effects on Depressive-Like Behavior, Hippocampal Neurogenesis, Neuroinflammation, and Gut Microbiota Composition

research Treatment of male rats with finasteride, an inhibitor of 5alpha-reductase enzyme, induces long-lasting effects on depressive-like behavior, hippocampal neurogenesis, neuroinflammation and gut microbiota composition

37 citations , September 2018 in “Psychoneuroendocrinology”

Finasteride treatment in male rats causes long-lasting effects on depression-like behavior, brain cell growth, inflammation, and gut bacteria composition.

research Inhibitory activities of Puerariae Flos against testosterone 5α-reductase and its hair growth promotion activities

34 citations , August 2011 in “Journal of Natural Medicines”

Puerariae Flos extract may help treat hair loss by blocking a hair loss-related enzyme and promoting hair growth.

research Incidence of type 2 diabetes mellitus in men receiving steroid 5α-reductase inhibitors: population based cohort study

29 citations , April 2019 in “BMJ. British medical journal”

Men taking dutasteride or finasteride have a slightly higher risk of developing type 2 diabetes.

research Discovery of Natural Steroid 5 Alpha-Reductase Inhibitors

11 citations , December 2018 in “Assay and Drug Development Technologies”

Natural herbal compounds might treat certain medical conditions by reducing DHT levels, but more research is needed to confirm their effectiveness and safety.

research Testosterone 5.ALPHA.-Reductase Inhibitory Active Constituents of Piper nigrum Leaf

44 citations , January 2007 in “Biological & pharmaceutical bulletin”

Black pepper leaf extract contains compounds that can block testosterone effects and promote hair growth.

Anti-Androgenic and Hair Growth Promoting Activities of Lygodii Spora (Spore of Lygodium Japonicum): Active Constituents Inhibiting Testosterone 5α-Reductase

research Anti-androgenic and Hair Growth Promoting Activities of Lygodii Spora (Spore of Lygodium japonicum) I. Active Constituents Inhibiting Testosterone 5.ALPHA.-Reductase.

38 citations , January 2002 in “Biological & Pharmaceutical Bulletin”

Lygodii Spora extract may help treat hair loss by blocking a hair loss-related enzyme and promoting hair growth.

research Geranylated Coumarins From Thai Medicinal Plant Mammea siamensis With Testosterone 5α-Reductase Inhibitory Activity

17 citations , March 2020 in “Frontiers in Chemistry”

Compounds from the plant Mammea siamensis may help treat hair loss.

Dutasteride, A Novel Dual 5-Alpha Reductase Inhibitor, Reduces Serum DHT to a Greater Extent Versus Finasteride and Achieves Maximal Reduction in a Larger Proportion of Patients

research Dutasteride, a novel dual 5-A reductase inhibitor, reduces serum DHT to a greater extent versus finasteride and achieves finasteride maximal reduction in a larger proportion of patients

12 citations , February 2003 in “European Urology Supplements”

Dutasteride reduces DHT more effectively than finasteride.

research Ficus benghalensis as Potential Inhibitor of 5α-Reductase for Hair Growth Promotion: In Vitro, In Silico, and In Vivo Evaluation

3 citations , December 2021 in “Frontiers in Pharmacology”

Ficus benghalensis leaf extracts can effectively promote hair growth and inhibit hair loss.

research Table 4_Computational drug discovery of potential 5α-reductase phytochemical inhibitors and hair growth promotion using in silico techniques.xlsx

May 2025 in “OPAL (Open@LaTrobe) (La Trobe University)”

Jamogenin and other compounds may help treat hair loss by inhibiting 5-alpha reductase.

research Table 3_Computational drug discovery of potential 5α-reductase phytochemical inhibitors and hair growth promotion using in silico techniques.xlsx

May 2025 in “OPAL (Open@LaTrobe) (La Trobe University)”

Jamogenin and other molecules may help treat hair loss by inhibiting 5-alpha reductase.

Phytotherapeutic Alternatives to the Use of Finasteride and Dutasteride as 5-Alpha Reductase Inhibitors in the Treatment of Androgenetic Alopecia: A Review

research Phytotherapeutic Alternatives to the Use of Finasteride and Dutasteride as 5-Alpha Reductase Inhibitors in the Treatment of Androgenetic Alopecia: A Review

January 2024 in “Brazilian Journal of Hair Health”

Some plant-based products might treat hair loss with fewer side effects than current medications.

Association of Breast Cancer in Men with Exposure to 5-Alpha Reductase Inhibitors: A RADAR Report

research Association of breast cancer in men with exposure to 5-α reductase inhibitors: A RADAR report.

May 2012 in “Journal of Clinical Oncology”

Taking 5-alpha reductase inhibitors might be linked to breast cancer in men.

research Finasteride: the first 5 alpha-reductase inhibitor.

34 citations , July 1993 in “PubMed”

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