April 2026 in “Brain Sciences” Finasteride may cause depression and suicidal thoughts, especially in young men.
35 citations
,
October 2011 in “Medicine and science in sports and exercise” Muscles can make their own androgens, which may help muscle growth.
January 2025 in “The World Journal of Men s Health” Finasteride temporarily suppresses brain activity, but some effects last even after stopping.
May 2023 in “Scientific Reports” The seed extract of Lepidium sativum L. can potentially treat hair loss, showing effects similar to 5% minoxidil.
100 citations
,
September 1999 in “British Journal of Dermatology” The study found that two enzymes linked to hair loss are located in different parts of the scalp, supporting a common treatment's effectiveness.
August 2024 in “Cosmetics” Peanut callus extract helps grow hair and prevent hair loss.
98 citations
,
April 1997 in “The Journal of Steroid Biochemistry and Molecular Biology” Finasteride effectively blocks rat enzymes, but with varying methods and strength.
72 citations
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January 2011 in “Current Pharmaceutical Design” S5αR inhibitors might help treat schizophrenia and other mental disorders but need more research.
7 citations
,
July 2018 in “Biological & Pharmaceutical Bulletin” Phyllanthus urinaria extract may help treat hair loss by blocking a hair-related enzyme.
6 citations
,
April 2017 in “Frontiers in Pharmacology” Chinese medicine may help treat hair loss by affecting genes and enzyme activity.
51 citations
,
May 2011 in “Phytotherapy Research” Ginseng, especially red ginseng, may help regrow hair and block a hair loss-related enzyme.
22 citations
,
October 2001 in “Biochemical Pharmacology” GI198745 is more potent and longer-lasting than finasteride, potentially better for treating hair loss.
January 2000 in “Annals of Dermatology” Finasteride effectively treats hair loss in men with minimal side effects.
44 citations
,
July 2012 in “Endocrine Practice” We need to learn more about 5α-reductases and neuroactive steroids to safely make drugs targeting these enzymes.
25 citations
,
January 2017 in “Steroids” Allopregnanolone increases growth and changes gene activity in human brain cancer cells.
8 citations
,
July 2021 in “F1000Research” Plant-based compounds might be a promising alternative for prostate cancer treatment with fewer side effects.
September 2004 in “Urology” Dutasteride may help prevent prostate cancer, but more research is needed.
January 2025 in “International Journal of Molecular Sciences” Fenugreek extract may help treat benign prostatic hyperplasia.
26 citations
,
September 2018 in “Neurobiology of Disease” Finasteride and dutasteride reduce unwanted movements from Parkinson's disease treatment by normalizing certain brain signals.
15 citations
,
October 2014 in “Hormone Molecular Biology and Clinical Investigation” Some hair loss and prostate drugs might increase the risk of diabetes and heart disease.
10 citations
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May 2018 in “Neuropharmacology” Drugs for hormone-related conditions might help treat mental disorders but could have serious side effects.
29 citations
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September 2014 in “Current Opinion in Endocrinology, Diabetes and Obesity” Finasteride and dutasteride effectively treat hair loss in men and women, but may cause side effects like low libido and depression.
June 2001 in “International Journal of Cosmetic Surgery and Aesthetic Dermatology” Finasteride improves hair growth in men with androgenetic alopecia.
13 citations
,
August 2007 in “Bioorganic & medicinal chemistry letters” A new compound effectively inhibits human 5α-reductase 1.
35 citations
,
April 2013 in “Sexual medicine reviews” 5-alpha reductase inhibitors slightly increase the risk of sexual and mood side effects, and breast growth in men.
4 citations
,
October 2018 in “International Braz J Urol” Taking 5-alpha reductase inhibitors does not increase the risk of breast cancer in men.
52 citations
,
February 2006 in “Current pharmaceutical design” 5α-reductase inhibitors and alpha-1 adrenergic antagonists together effectively treat benign prostatic hyperplasia, with long-term benefits.
31 citations
,
January 2017 in “Advances in Experimental Medicine and Biology” Low testosterone and 5α-reductase inhibitors can harm men's metabolic and sexual health; testosterone therapy may help, but discussing 5α-RIs' side effects is important.
15 citations
,
January 2017 in “Experimental Neurology” Finasteride reduces movement issues in Parkinson's disease rats.
7 citations
,
April 2015 in “General and Comparative Endocrinology” Finasteride negatively affects fish reproduction and gonadal development.