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14,15-EET may help reduce poststroke pain by affecting certain brain proteins.

Many medications may be linked to cognitive disorders, but most lack warnings on labels.

Smaller substituents at C-17 enhance the inhibitory activity of progesterone derivatives on 5alpha-reductase.

Taking 5-alpha reductase inhibitors might be linked to breast cancer in men.

Hair loss drugs like finasteride may cause lasting sexual and mood side effects, and more research is needed to understand these risks.

Using 5 alpha reductase inhibitors may increase dementia risk in the first two years.

Steroid 5α-reductase evolved from protists and diversified in eukaryotes, with specific roles in mammals and plants.

Drug approvals slowed in 2Q22, but notable drugs like Amvuttra, Camzyos, and Olumiant were approved.

Finasteride may help reduce opioid use.

Off-label drug use can be risky but sometimes beneficial when standard treatments fail.

5-alpha-reductase inhibitors may reduce COVID-19 symptoms in bald males.

Finasteride for hair loss in young men may significantly increase the risk of sexual dysfunction.

Some skin medications can have harmful interactions with the COVID-19 drug nirmatrelvir-ritonavir, but not with molnupiravir.

Finasteride irreversibly affects human steroid 5α-reductase 2, providing insight into its catalytic mechanism and disease-related mutations.

The document did not conclude on apremilast's effectiveness for severe alopecia areata.

Finasteride shows promise for treating hair loss and excessive hair growth, but more research is needed to confirm its effectiveness and safety.

5α-reductases increase epitestosterone's effect on androgen receptors.

Blocking the CCR5 receptor may be a new way to treat hair loss from alopecia areata.

Blocking CCR5 can prevent and improve hair loss in alopecia areata.

New anti-acne medications are being tested to offer alternatives to current treatments.

Some medications can help increase sexual desire and function in women.

Some medications can improve skin conditions, while lifestyle factors like smoking and drinking may worsen them; treatments like monoclonal antibodies and imiquimod cream show promise for certain skin diseases.

Finasteride may increase the risk of suicidality and depression, especially in younger people.

Finasteride and dutasteride are equally effective and safe for treating benign prostatic hyperplasia.

Some hormone-related drugs may protect brain cells in Parkinson's disease differently in men and women.

The document sets criteria for diagnosing long-term sexual dysfunctions caused by certain medications.

Compound 7b is a promising candidate for treating benign prostatic hyperplasia and prostate cancer.

The research helps understand how finasteride works and aids drug development.