188 citations
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June 1998 in “Molecular cell” Researchers created a mouse with the same mutation as humans with trichothiodystrophy, showing similar symptoms and confirming the condition is due to defects in DNA repair and gene activity.
137 citations
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January 2006 in “Frontiers in bioscience” CRH in the skin acts like the body's stress response system, affecting cell behavior and immune activity.
97 citations
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March 2010 in “The American Journal of Human Genetics” A mutation in the KRT74 gene causes tightly curled hair.
78 citations
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May 2019 in “Frontiers in Cellular and Infection Microbiology” DPK-060 in poloxamer gel effectively treats skin infections, but nanocarriers don't enhance its efficacy.
75 citations
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July 2016 in “New phytologist” The protein RSL4 is crucial for making root hairs longer by controlling genes related to cell growth.
62 citations
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January 2009 in “Biochemistry” Vitamin D receptor binds similarly to natural and synthetic ligands, affecting gene regulation.
53 citations
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March 2006 in “Biopolymers” TTD hair is brittle due to fewer sulfur amino acids and unstable disulfide bonds.
49 citations
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December 2022 in “Pharmacological Reviews” Targeting androgen receptors shows promise for treating triple-negative breast cancer, but more research is needed.
45 citations
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April 2001 in “The journal of investigative dermatology/Journal of investigative dermatology” Different Myc family proteins are located in various parts of the hair follicle and may affect stem cell behavior.
26 citations
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June 2024 in “Frontiers in Immunology” SOCS1 and SOCS3 help control skin inflammation and are important for developing treatments for skin diseases.
26 citations
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July 2019 in “Dermatology and Therapy” The conclusion is that genetic testing is important for diagnosing and treating various genetic hair disorders.
25 citations
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October 2002 in “The journal of investigative dermatology/Journal of investigative dermatology” Mouse profilaggrin helps in skin cell differentiation and may be involved in calcium signaling.
24 citations
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February 2022 in “Journal of Biological Chemistry” Carvacrol activates the TRPV3 channel, which may help design new skin treatments.
23 citations
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January 1981 Hair is mostly made of three protein types: helical, high-sulfur, and high-tyrosine.
22 citations
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July 2016 in “Cellular and Molecular Life Sciences” Genetic changes in mice help understand skin and hair disorders, aiding treatment development for acne and hair loss.
22 citations
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July 1998 in “Journal of Investigative Dermatology” The 4C32 gene may help in mouse skin development and differentiation.
22 citations
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October 1996 in “Dermatologic clinics” Understanding intermediate filaments helps explain hair health and related diseases.
21 citations
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July 2018 in “International Journal of Molecular Sciences” Foxn1 is crucial for skin development and healing, and altering its expression may aid regenerative medicine.
19 citations
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August 2022 in “Plant Signaling & Behavior” ROS and calcium oscillations are essential for root hair growth in plants.
15 citations
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August 2020 in “Analytical chemistry” Hair lipids do not protect against humidity.
15 citations
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April 2016 in “Hormones” Mutations in the NR3C1 gene cause a rare condition that affects hormone signaling and can lead to various symptoms, with dexamethasone as a treatment option.
14 citations
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April 2013 in “Journal of dermatological science” Hairless protein reduces Msx2 gene activity, affecting hair follicle development.
12 citations
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April 2015 in “BMC research notes” Root hairs in cereal crops can grow beyond the usual zone, and using Turface® clay helps study this.
11 citations
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June 2017 in “Asian-Australasian journal of animal sciences” Fox genes are important for hair growth and development in cashmere goats.
9 citations
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November 2024 in “Biotechnology for Sustainable Materials” Keratin-based biomaterials are promising for wound healing, drug delivery, and nerve regeneration due to their biodegradability and biocompatibility.
8 citations
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December 2017 in “Small Ruminant Research” Variation in the TCHH gene affects wool curliness in sheep.
7 citations
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November 2006 in “Journal of immunological methods” The method can help diagnose and monitor diabetes by analyzing hair.
7 citations
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November 2022 in “Toxics” The method accurately measures 19 steroid hormones in human blood and urine using a small sample and is suitable for large-scale monitoring.
6 citations
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August 2022 in “Science immunology” Foxn1 gene regulation is crucial for thymus development but not for hair growth.
6 citations
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May 2022 in “Colloids and Surfaces B: Biointerfaces” Eating peptides from certain shellfish may help wounds heal faster by reducing inflammation.