Search

for
Search:

Did you mean Abnormal Hair Follicles?

GlossaryAbnormal Hair Follicles

hair follicles deviating from normal structure or function

Abnormal hair follicles refer to hair follicles that deviate from their typical structure or function, often leading to issues like hair thinning, hair loss, or unusual hair growth patterns. These abnormalities can be caused by genetic factors, hormonal imbalances, autoimmune conditions, or external factors such as trauma or certain medications. For professionals, understanding the underlying cause of these abnormalities is crucial for diagnosing and treating hair-related disorders effectively.

Related Terms

Sort by

Research

30 / 1000+ results

research Skin-specific expression of a truncated E1a oncoprotein binding to p105-Rb leads to abnormal hair follicle maturation without increased epidermal proliferation.

30 citations , June 1993 in “The Journal of Cell Biology”

The oncoprotein causes abnormal hair growth without increasing skin cancer risk.

research Trichodysplasia spinulosa associated with chemotherapy for acute lymphocytic leukaemia

55 citations , May 2007 in “Australasian journal of dermatology”

Two boys developed a viral skin infection during chemotherapy, which resolved with improved immune function.

research The importance of basonuclin 2 in adult mice and its relation to basonuclin 1

14 citations , March 2016 in “Mechanisms of Development”

Basonuclin 2 is vital for the development of facial bones, hair follicles, and male germ cells in adult mice, and its absence can lead to dwarfism and abnormal follicles.

research iRhom2 Mutation Leads to Aberrant Hair Follicle Differentiation in Mice

15 citations , December 2014 in “PLoS ONE”

A mutation in the iRhom2 gene causes hairless mice due to abnormal hair follicle development.

research Multiple Roles of Integrin-Linked Kinase in Epidermal Development, Maturation and Pigmentation Revealed by Molecular Profiling

9 citations , May 2012 in “PLOS ONE”

ILK is essential for skin development, pigmentation, and healing.

research Genetic analysis of a novel antioxidant multi-target iron chelator, M30 protecting against chemotherapy-induced alopecia in mice

9 citations , February 2019 in “BMC cancer”

M30 is a promising treatment for preventing hair loss during chemotherapy.

research Sgk3 links growth factor signaling to maintenance of progenitor cells in the hair follicle

53 citations , August 2005 in “The Journal of Cell Biology”

Sgk3 is essential for normal hair follicle growth and maintenance.

research The transcriptional repressor CDP (Cutl1) is essential for epithelial cell differentiation of the lung and the hair follicle

165 citations , September 2001 in “Genes & development”

CDP is crucial for lung and hair follicle cell development.

The Overexpression of R-Spondin 3 Affects Hair Morphogenesis and Development Along with the Formation and Maturation of Hair Follicle Stem Cells

research The overexpression of R-spondin 3 affects hair morphogenesis and hair development along with the formation and maturation of the hair follicle stem cells

6 citations , September 2024 in “Frontiers in Physiology”

Overexpression of R-spondin 3 leads to sparse hair and impaired hair regeneration.

research Wound Healing Mechanisms

October 1982 in “American Journal of Nursing”

Wound healing is a complex process involving different cells and stages, leading to scar tissue formation and strength increase over time.

research Epidermal Dysplasia and Abnormal Hair Follicles in Transgenic Mice Overexpressing Homeobox Gene MSX-2

49 citations , August 1999 in “Journal of Investigative Dermatology”

Overexpressing the MSX-2 gene in mice causes skin and hair growth issues.

research Arachidonate 12-Lipoxygenase Inhibitors Promote S100A3 Citrullination in Cultured SW480 Cells and Isolated Hair Follicles

4 citations , January 2017 in “Biological & pharmaceutical bulletin”

Inhibiting ALOX12 can help hair cuticle maturation by increasing S100A3 citrullination.

research Tyrosinase Depletion Prevents the Maturation of Melanosomes in the Mouse Hair Follicle

31 citations , November 2015 in “PloS one”

Reducing Tyrosinase prevents mature color pigment cells from forming in mouse hair.

Activated Hair Follicle Stem Cells and Wnt/β-Catenin Signaling Involved in Pathogenesis of Sebaceous Neoplasms

research Activated Hair Follicle Stem Cells and Wnt/β-catenin Signaling Involve in Pathnogenesis of Sebaceous Neoplasms

19 citations , January 2014 in “International Journal of Medical Sciences”

Abnormal activation of hair follicle stem cells and Wnt/β-catenin signaling contributes to sebaceous neoplasms.

research Targeted expression of SV40 T antigen in the hair follicle of transgenic mice produces an aberrant hair phenotype

14 citations , March 1995 in “Journal of cell science”

SV40 T antigen in hair follicles causes abnormal hair and health issues in mice.

research Pharmacological BACE1 and BACE2 inhibition induces hair depigmentation by inhibiting PMEL17 processing in mice

58 citations , February 2016 in “Scientific reports”

Blocking BACE1 and BACE2 enzymes causes hair color loss in mice.

research Histologic Study of the Regeneration Process of Human Hair Follicles Grafted onto SCID Mice after Bulb Amputation

19 citations , November 2001 in “Journal of Investigative Dermatology Symposium Proceedings”

Human hair follicles can regenerate and recover after severe injury by going through a brief abnormal resting phase before growing again.

research Learning from nudity: lessons from the nude phenotype

86 citations , October 2005 in “Experimental Dermatology”

The Foxn1 gene mutation causes hairlessness and immune system issues, and understanding it could lead to hair growth disorder treatments.

research Abnormal differentiation of epidermis in transgenic mice constitutively expressing cyclooxygenase-2 in skin

201 citations , May 2001 in “Proceedings of the National Academy of Sciences”

Overexpression of COX-2 in mice skin causes abnormal skin and hair development.

research A pair of transmembrane receptors essential for the retention and pigmentation of hair

11 citations , May 2012 in “Genesis”

Bmpr2 and Acvr2a receptors are crucial for hair retention and color.

research Loose Anagen Hair as a Cause of Hereditary Hair Loss in Children

55 citations , October 1992 in “Archives of Dermatology”

Loose Anagen Hair Syndrome is a hereditary condition causing hair loss in children due to abnormal hair follicles.

research 1386 Trichodysplasia spinulosa small T antigen drives ectopic hair follicle development in adult transgenic mice

1 citations , April 2018 in “Journal of Investigative Dermatology”

The Trichodysplasia spinulosa virus protein can cause abnormal hair growth in mice.

Expression of EZH2 in the Skin of Developing Human Fetuses and Adults: A Comparative Study

research Gelişmekte olan insan fetüslerinin ve yetişkinlerin derisinde EZH2 ekspresyonu: karşılaştırmalı bir çalışma

September 2023 in “Çukurova medical journal (Online)/Çukurova medical journal”

EZH2 levels decrease as fetuses develop and are higher in adult skin, which may affect skin growth and repair.

research Hair Follicle Regeneration Using Grafted Rodent and Human Cells

96 citations , April 2007 in “Journal of Investigative Dermatology”

Grafted rodent and human cells can regenerate hair follicles, but efficiency decreases with age.

The G-Protein Coupled Receptor Kinase 2 (GRK2) Orchestrates Hair Follicle Homeostasis

research The G-Protein Couple Receptor Kinase 2 (GRK2) Orchestrates Hair Follicle Homeostasis

April 2024 in “bioRxiv (Cold Spring Harbor Laboratory)”

GRK2 is essential for healthy hair follicle function, and its absence can lead to hair loss and cysts.

The Lysosomal Protease Cathepsin L Is an Important Regulator of Keratinocyte and Melanocyte Differentiation During Hair Follicle Morphogenesis and Cycling

research The Lysosomal Protease Cathepsin L Is an Important Regulator of Keratinocyte and Melanocyte Differentiation During Hair Follicle Morphogenesis and Cycling

146 citations , May 2002 in “The American journal of pathology”

Cathepsin L is essential for normal hair growth and development.

research Hair Loss Caused by Gain-of-Function Mutant TRPV3 Is Associated with Premature Differentiation of Follicular Keratinocytes

11 citations , March 2021 in “The journal of investigative dermatology/Journal of investigative dermatology”

A gene mutation causes early keratinocyte maturation leading to hair loss in Olmsted syndrome.