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GlossaryAcetylcholinesterase

breaks down acetylcholine in the synaptic cleft

Acetylcholinesterase (AChE) is an enzyme that breaks down the neurotransmitter acetylcholine in the synaptic cleft, which is the space between nerve cells. This process is crucial for terminating nerve impulses and allowing muscles to relax after contraction. Inhibiting AChE can lead to prolonged muscle contraction and is a mechanism used by certain nerve agents and pesticides.

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Finasteride Has Regionally Different Effects on Brain Oxidative Stress and Acetylcholinesterase Activity in Acute Thioacetamide-Induced Hepatic Encephalopathy in Rats

research Finasteride Has Regionally Different Effects on Brain Oxidative Stress and Acetylcholinesterase Activity in Acute Thioacetamide-Induced Hepatic Encephalopathy in Rats

11 citations , August 2015 in “PLOS ONE”

Finasteride affects brain stress and enzyme activity differently in various regions, possibly helping with liver-related brain issues.

research Development and Validation of an HPLC-PDA Method for Quantitation of Ten Marker Compounds from Eclipta prostrata (L.) and Evaluation of Their Protein Tyrosine Phosphatase 1B, α-Glucosidase, and Acetylcholinesterase Inhibitory Activities

4 citations , December 2020 in “Natural Product Sciences”

The method identified and measured ten compounds from Eclipta prostrata, showing significant enzyme inhibitory effects.

research Anti-acetylcholinesterase and Antioxidant Effects of Identified Compounds from Houttuynia cordata

September 2022 in “The Korean Tea Society”

Houttuynia cordata compounds may help with anti-aging and hair loss.

research The effects of finasteride (FIN) and thioacetamide (TAA) on acetylcholinesterase (AchE) activity in various brain regions.

December 2015 in “PLOS ONE”

research Baiting Proteins with C₆₀

106 citations , April 2010 in “ACS Nano”

C60 fullerenes can alter protein function and may help develop new disease inhibitors.

research Neurobehavioral protective properties of curcumin against the mercury chloride treated mice offspring

27 citations , October 2018 in “Saudi Journal of Biological Sciences”

Curcumin can protect against mercury's harmful effects on brain and behavior.

research A network pharmacology-based approach to explore mechanism of action of medicinal herbs for alopecia treatment

8 citations , February 2022 in “Scientific Reports”

Medicinal herbs might treat hair loss by affecting genes and pathways related to lipid and glycerophospholipid metabolism.

research Acquired Localized Hypertrichosis Induced by Rivastigmine

3 citations , January 2016 in “Case reports in dermatological medicine”

An 80-year-old man grew extra hair on his forearms after starting Alzheimer's medication rivastigmine.

Angelica Gigas Nakai (Korean Dang-Gui) Root Alcoholic Extracts in Health Promotion and Disease Therapy: Active Phytochemicals and In Vivo Molecular Targets

research Angelica gigas Nakai (Korean Dang-gui) Root Alcoholic Extracts in Health Promotion and Disease Therapy – active Phytochemicals and In Vivo Molecular Targets

2 citations , January 2025 in “Pharmaceutical Research”

Angelica gigas Nakai root extracts may help with cancer, pain, memory loss, and metabolic issues.

research The Muscarinic Acetylcholine Receptor in Dermal Papilla Cells Regulates Hair Growth

February 2026 in “International Journal of Molecular Sciences”

Muscarinic acetylcholine receptors in skin cells help regulate and promote hair growth.

research The muscarinic acetylcholine receptor in dermal papilla cells regulates hair growth

April 2024

Muscarinic acetylcholine receptors help regulate and promote hair growth.

research Enzyme Inhibitory Activities of Marine Sponges Against Cholinesterase and 5α-Reductase

June 2019

Marine sponges from Tabuhan Island can inhibit enzymes linked to Alzheimer's and hair loss.

research GC–MS Profiling, Antioxidant, Enzyme Inhibition, Molecular Docking, and ADME Investigation of the n ‐Hexane Extract and the Essential Oil of Platycladus orientalis (L.) Franco Fruits

January 2026 in “Chemistry & Biodiversity”

Platycladus orientalis fruit extracts have antioxidant and enzyme-inhibiting properties, useful for health and food applications.

Larvicidal Potential, Antimicrobial Properties and Molecular Docking Analysis of Egyptian Mint (Mentha Rotundifolia) Against Culex Pipiens L. (Diptera: Culicidae) and Midgut-Borne Staphylococcus Aureus

research Larvicidal potential, antimicrobial properties and molecular docking analysis of Egyptian Mint (Mentha rotundifolia) against Culex pipiens L. (Diptera: Culicidae) and Midgut-borne Staphylococcus aureus

January 2024 in “Scientific reports”

Egyptian Mint effectively kills mosquito larvae and inhibits certain bacteria.

research Antioxidant and Cholinesterase Inhibitory Activity of a New Peptide From Ziziphus jujuba Fruits

69 citations , September 2013 in “American Journal of Alzheimer s Disease & Other Dementias®”

Snakin-Z from jujube fruits may help treat Alzheimer's due to its enzyme inhibition and antioxidant properties.

research Pharmacological Efficacy of Tamarix aphylla: A Comprehensive Review

20 citations , December 2021 in “Plants”

Tamarix aphylla may be effective for various medical conditions, but more research is needed to confirm its safety and effectiveness.

research Assessment of the Chemical Profile and Potential Medical Effects of a Flavonoid-Rich Extract of Eclipta prostrata L. Collected in the Central Highlands of Vietnam

6 citations , October 2023 in “Pharmaceuticals”

Eclipta prostrata extract may help with memory and diabetes due to its antioxidant and enzyme-inhibiting properties.

PEGylated Flavonoid Aspasomes as a Brain-Targeted Nano-Vesicular Platform for Enhanced Neuroprotection in Stress-Induced Cognitive Dysfunction

research PEGylated Flavonoid Aspasomes as a Brain-Targeted Nano-Vesicular Platform for Enhanced Neuroprotection in Stress-Induced Cognitive Dysfunction

May 2026 in “AAPS PharmSciTech”

PEGylated flavonoid Aspasomes improve brain protection and memory in stress-related disorders.

research Experimental and Clinical Pharmacology ofZiziphus jujubaMills

31 citations , January 2017 in “Phytotherapy Research”

Ziziphus jujuba Mills may have health benefits, but more research is needed to confirm its safety and effectiveness.

research Phenolic composition, enzyme inhibitory, and antioxidant activity of Bituminaria bituminosa

6 citations , October 2016 in “Food Science and Biotechnology”

The water extract of Bituminaria bituminosa, high in phenolic compounds, shows strong antioxidant and enzyme inhibitory potential.

research Antiparasitic efficacy of geraniol from Apiaceae family in scabies treatment

May 2025 in “Scientific Reports”

Geraniol effectively treats scabies and is safe for use.

research The potential involvement of cholinergic system in finasteride induced cognitive dysfunction

November 2020 in “Psychoneuroendocrinology”

Finasteride might affect memory by impacting cholinergic system.

research Increased acetylcholine levels in skin biopsies of patients with atopic dermatitis

96 citations , March 2003 in “Life Sciences”

Atopic dermatitis patients have much higher acetylcholine levels in their skin, which may cause itching.

research Review of Pharmacological Effects ofMyrtus communisL. and its Active Constituents

165 citations , February 2014 in “Phytotherapy Research”

Myrtle has various health benefits and potential for medicine development.

research DrugNet: Network-based drug–disease prioritization by integrating heterogeneous data

158 citations , January 2015 in “Artificial Intelligence in Medicine”

DrugNet effectively identifies new uses for existing drugs and may save resources in drug development.

research Alopecia areata: A multifactorial autoimmune condition

148 citations , December 2018 in “Journal of autoimmunity”

Alopecia areata is an autoimmune disease causing patchy hair loss, often with other autoimmune disorders, but its exact causes are unknown.

research Lignans and Neolignans: Plant secondary metabolites as a reservoir of biologically active substances

112 citations , May 2019 in “Pharmacological Research”

Lignans and neolignans from plants may help protect against various health issues, including cancer and heart disease.

research HPLC-ESI-MSn characterization of phenolic compounds, terpenoid saponins, and other minor compounds in Bituminaria bituminosa

76 citations , February 2015 in “Industrial Crops and Products”

Researchers found over 40 compounds in Bituminaria bituminosa, including many flavonoids and some with potential for medical and hair care uses.

research Nutritional and therapeutic importance of Daucus carota- A review

60 citations , June 2017 in “IOSR Journal of Pharmacy (IOSRPHR)”

Carrots are nutritious and offer many health benefits, including antioxidant and anti-inflammatory effects.

research Semecarpus anacardium Linn.: A review

59 citations , January 2010 in “Pharmacognosy Reviews/Bioinformatics Trends/Pharmacognosy review”

Semecarpus anacardium Linn. has many medicinal benefits.