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November 2012 in “Expert Opinion on Therapeutic Patents” The document concludes that research on sulfatase inhibitors should continue due to their potential in treating various diseases, despite some clinical trial failures.
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December 2010 in “The journal of investigative dermatology/Journal of investigative dermatology” Disrupting Acvr1b in mice causes severe hair loss and thicker skin.
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July 2014 in “Journal of biological chemistry/The Journal of biological chemistry” Heparan sulfate is important for hair growth, preventing new hair formation in mature skin, and controlling oil gland development.
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May 2003 in “Mini-reviews in Medicinal Chemistry” New steroidal compounds could be effective for treating conditions related to 5α-reductase enzyme activity.
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November 2024 in “Molecular Biomedicine” Engineered extracellular vesicles show promise for targeted therapy but need more research for clinical use.
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November 2011 in “The Journal of Dermatology” Some hair loss disorders are caused by genetic mutations affecting hair growth.
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June 2013 in “Scientific Reports” A gene variant in KRT71 causes the curly fur in Selkirk Rex cats.
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October 2002 in “Endocrinology” Vitamin D3 analogs can promote hair growth in mice genetically prone to hair loss.
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March 2018 in “Trends in Plant Science” pH, calcium, and reactive oxygen species regulate plant cell growth, with key roles for NADPH oxidases and plasma membrane H+-ATPases.
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August 2018 in “Facial Plastic Surgery Clinics of North America” The document explains hair biology, the causes of hair loss, and reviews various hair loss treatments.
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February 1998 in “The journal of investigative dermatology/Journal of investigative dermatology” Two specific hair keratin genes are active during hair growth and decline as hair transitions to rest.
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March 2013 in “Gene” Signaling pathways are crucial for hair growth in goats.
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October 2020 in “Nature Communications” Finasteride irreversibly affects human steroid 5α-reductase 2, providing insight into its catalytic mechanism and disease-related mutations.
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August 2005 in “The journal of investigative dermatology/Journal of investigative dermatology” Researchers found new genes involved in hair growth, which could help develop new hair treatments.
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March 2018 in “Dermatology and Therapy” EPC-CM can reduce skin aging signs by boosting the skin's defense system.
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January 1994 in “Clinics in Dermatology” Artificial skin is improving wound healing and shows potential for treating different types of wounds.
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September 1998 in “The Journal of Steroid Biochemistry and Molecular Biology” Finasteride inhibits enzyme activity in rhesus macaques, suggesting they're useful for evaluating similar drugs.
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January 2022 in “Biomaterials Science” Non-viral vectors show promise for safe and effective CRISPR/Cas9 gene editing in treating diseases.
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October 2012 in “Cell Transplantation” Cells treated with Wnt-10b can grow hair after being transplanted into mice.
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August 2006 in “Critical Reviews in Plant Sciences” The tropical legume Sesbania rostrata can form nodules in waterlogged conditions using a different method that involves plant hormones and specific genes.
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August 2017 in “PLoS ONE” 61 functional keratin genes were identified in dogs and horses, leading to updated gene annotations.
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February 2009 in “Chemistry & Biodiversity” Ganoderma lucidum may help treat prostate cancer by blocking male hormones and slowing cancer cell growth.
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January 2008 in “Journal of Korean Medical Science” NGAL may help maintain skin balance and is linked to skin disorders and cancers.
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July 1988 in “Clinics in dermatology” Thioglycolate lotions are the most popular method for permanent waving and hair straightening.
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February 2022 in “Cell Death Discovery” ECM1-modified stem cells can effectively treat liver cirrhosis.