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GlossaryActifolic

Actifolic is a dietary supplement formulated to support hair health and combat hair loss. It contains a blend of vitamins, minerals, and botanical extracts, including folic acid, which is essential for cell division and growth, making it relevant in the context of hair biology. Key distinguishing characteristics of Actifolic include its focus on promoting hair follicle health and its potential role in enhancing the overall vitality of hair, particularly in individuals experiencing thinning or shedding.

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Clinical, Histopathological and Immunological Characteristics of Exfoliative Cutaneous Lupus Erythematosus in 25 German Short-Haired Pointers

research Clinical, histopathological and immunological characteristics of exfoliative cutaneous lupus erythematosus in 25 German short‐haired pointers

38 citations , August 2005 in “Veterinary dermatology”

A disease causing skin issues in young adult German short-haired pointers is hereditary, with most affected dogs not responding to treatment.

research Folicall Hair Health Support Review – Does It Really Work?

September 2020

research [RETRACTED] Folicrex: Know This First Before Buying Hair Regrowth Pills? v1

April 2022

Folicrex may help with hair growth and health but lacks clinical evidence.

research Control of pelage hair follicle development and cycling by complex interactions between follistatin and activin

81 citations , January 2003 in “The FASEB Journal”

Follistatin helps hair growth and cycling, while activin prevents it.

research Hair growth control by follistatin

January 2004 in “Enshou saisei”

Follistatin is important for hair growth and could help treat hair loss.

research 2′‐Fucosyllactose Alleviates Hair Loss in Testosterone‐Induced Androgenic Alopecia Mice

January 2025 in “Journal of Food Biochemistry”

2′‐Fucosyllactose reduces hair loss and promotes hair growth in mice.

research Potential Biomolecule Fisetin: Molecular and Pharmacological Perspectives

March 2024 in “Current materials science”

Fisetin, found in fruits and vegetables, may help treat various health conditions like inflammation, diabetes, heart issues, cancer, and hair loss.

research Keratinocyte-derived follistatin regulates epidermal homeostasis and wound repair

28 citations , December 2008 in “Laboratory investigation”

Activin activation in skin cells speeds up wound healing without affecting scar quality.

research Verstärkter Haarwuchs unter Langzeittokolyse mit Fenoterol** unter Berücksichtigung von Testosteron, Androstandiol, Cortisol und ACTH*

9 citations , November 1980 in “Geburtshilfe und Frauenheilkunde”

Fenoterol treatment causes increased hair growth due to higher metabolism in hair follicles, not hormones.

research Folic acid therapy for alopecia in a Charolais calf

1 citations , November 1988 in “Veterinary Record”

Folic acid helped a calf regrow hair lost due to deficiency.

research [RETRACTED] Folicrex: Know This First Before Buying Hair Regrowth Pills? v1

April 2022

research Topical tofacitinib for patients with lichen planopilaris and/or frontal fibrosing alopecia

3 citations , February 2024 in “Journal of the American Academy of Dermatology”

Topical tofacitinib cream may help treat certain hair loss conditions with fewer risks.

Using MALDI-MSI Analysis to Study Distribution of FOL-005, a Potent, Novel Inhibitor of Human Hair Growth, After Subcutaneous Injection in Mice

research 695 Using MALDI-MSI analysis to study distribution of FOL-005, a potent, novel inhibitor of human hair growth, after subcutaneous injection in mice

April 2016 in “Journal of Investigative Dermatology”

FOL-005, a new substance, was found to reduce hair growth without toxicity when injected into skin, suggesting it could be used to treat excessive hair growth.

research α‐Difluoromethylornithine, a polyamine inhibitor: its potential role in controlling hair growth and in cancer treatment and chemo‐prevention

9 citations , April 2006 in “International Journal of Dermatology”

DFMO may help control hair growth and treat cancer.

research ORAL TOFACITINIB IN MODERATE AND SEVERE ALOPECIA AREATA: CASE SERIES OF 14 PATIENTS

March 2023 in “PARIPEX INDIAN JOURNAL OF RESEARCH”

Tofacitinib helped regrow hair in most patients with severe hair loss.

research Monoterpenoid Loliolide Regulates Hair Follicle Inductivity of Human Dermal Papilla Cells by Activating the Akt/ ¥-Catenin Signaling Pathway

37 citations , November 2019 in “Journal of Microbiology and Biotechnology”

Loliolide can boost hair growth by activating specific cell pathways.

Alfatradiol (0.025%) - An Effective and Safe Treatment Option for Androgenetic Alopecia in Women and Men

research Alfatradiol (0,025 %) - Eine wirksame und sichere Therapieoption zur Behandlung der androgenetischen Alopezie bei Frauen und Männern

10 citations , December 2005 in “Aktuelle Dermatologie”

Alfatradiol (0.025%) is an effective and safe treatment for hair loss in both women and men.

research Treatment of an alopecia areata patient with tofacitinib results in regrowth of hair and changes in serum and skin biomarkers

70 citations , April 2016 in “Experimental Dermatology”

A patient with alopecia areata regrew hair after taking tofacitinib and showed changes in certain blood and skin markers.

research The role of activins and follistatins in skin and hair follicle development and function

45 citations , October 2008 in “Cytokine & Growth Factor Reviews”

Activins and follistatins, part of the TGFβ family, are crucial for hair follicle development and skin health, affecting growth, repair, and the hair cycle.

research Tofacitinib 2% ointment, a topical Janus kinase inhibitor, for the treatment of alopecia areata: A pilot study of 10 patients

48 citations , November 2017 in “Journal of the American Academy of Dermatology”

Tofacitinib 2% ointment helped hair regrow in 3 out of 10 patients with alopecia areata, but caused side effects like scalp irritation and raised cholesterol in some.

research Geriatric Dermatologic Therapy

February 2026

Elderly skin care needs personalized treatment, early intervention, and integrated psychiatric care.

research Ferulic acid promotes hair growth via estrogen receptor alpha activation in cultured human dermal papilla cells

March 2026 in “Scientific Reports”

Ferulic acid may help hair grow by activating certain receptors in cells.

research Successful Hair Regrowth in Early Frontal Fibrosing Alopecia With Combination Therapy

March 2026 in “Cureus”

Early combination therapy can effectively regrow hair in frontal fibrosing alopecia.

research Successful Treatment with Fusidic Acid in a Patient with Folliculitis Decalvans.

2 citations , March 2019 in “PubMed”

Fusidic acid successfully treated a rare scalp infection with hair regrowth and no recurrence after 6 months.

research Autophagy Stimulation Improves Erythroid Proliferative Capacity in Models of SF3B1 Mutant MDS

April 2017 in “Leukemia research”

Tofacitinib helped most teenagers in the study regrow hair with mild side effects.

research 075 Clinical investigation of JAK inhibitor Tofacitinib in scarring alopecias

1 citations , April 2017 in “Journal of Investigative Dermatology”

Tofacitinib may slow hair loss in scarring alopecias but is unlikely to regrow significant hair.

FGF7-Dependent Inhibition of Human Hair Growth by an Osteopontin-Derived Peptide: A Novel Solution for Hirsutism and Hypertrichosis

research 1371 FGF7-dependent inhibition of human hair growth byan osteopontin-derived peptide: A novel solution for hirsutism and hypertrichosis?

April 2018 in “Journal of Investigative Dermatology”

A new peptide, FOL-005, may help treat excessive hair growth by reducing a hair growth promoter, FGF7.

research Systemic Tofacitinib in Alopecia Areata: A Single Center Retrospective Descriptive Cohort Study

1 citations , January 2024 in “Arab Board Medical Journal”

Tofacitinib effectively regrows hair in alopecia areata patients, especially in younger individuals, with manageable side effects.

research Tofacitinib therapy for children with severe alopecia areata

39 citations , January 2019 in “Journal of the American Academy of Dermatology”

Tofacitinib may help treat severe childhood alopecia areata, but risks require careful consideration.

research An osteopontin‐derived peptide inhibits human hair growth at least in part by decreasing fibroblast growth factor‐7 production in outer root sheath keratinocytes

19 citations , September 2019 in “British Journal of Dermatology”

FOL-005 peptide can reduce human hair growth by lowering FGF7 levels.