research Neuroactive Steroids: Functions, Mechanisms of Action and Physiologic Relevance
Allopregnanolone may enhance alcohol's effects on dopamine neurons, influencing addiction risk.
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960-990 / 1000+ resultsresearch Peptidylarginine Deiminase Isoforms Are Differentially Expressed in the Anagen Hair Follicles and Other Human Skin Appendages
PAD enzymes play a key role in hair growth and structure.
research Acrodermatitis dysmetabolica in an infant with maple syrup urine disease
Increasing isoleucine intake improved skin and health issues in an infant with maple syrup urine disease.
research Case 3: The Hypothermic Newborn
The infant with a urea cycle disorder improved with treatment and a liver transplant.
research Androgen Conjugates: Physiology and Clinical Significance
Androgen conjugates might be better indicators of skin sensitivity to hormones in women with excessive hair growth.
research A population pharmacokinetic model for individualized regimens of finasteride according to CYP3A5 genotype and liver function
Finasteride dosages should be adjusted based on CYP3A5 genotype and liver function to avoid side effects.
research Docking and Molecular Dynamics Identify Leads against 5 Alpha Reductase 2 for Benign Prostate Hyperplasia Treatment
New compounds show promise for treating benign prostate hyperplasia with fewer side effects.
research Inhibition of 5α-reductase alters pregnane metabolism in the late pregnant mare
Inhibiting 5α-reductase increases progesterone levels in late pregnant mares.
research The use of phosphodiesterase inhibitors for the treatment of alopecia
Caffeine shows promise for treating some types of hair loss, but more research is needed.
research Determination of Finasteride in Human Plasma by LC/MS/MS and Study on Its Pharmacokinetics
The method accurately measures finasteride in plasma and is suitable for clinical use.
research Novel synthesis of nicotinamide derivatives of cytotoxic properties
Newly made nicotinamide compounds could potentially treat cancer.
research DHT and E2 synthesis-related proteins and receptors expression in male yak skin during different hair follicle stages
Male yak hair growth is influenced by DHT synthesis, which is promoted by 5α-red1 and AR during growth phases, while E2 may inhibit growth through ERα.
research Niacin deficiency increases the sensitivity of rats to the short and long term effects of ethylnitrosourea treatment.
Niacin deficiency makes rats more sensitive to cancer-causing chemicals.
research Status of Serum Vitamin-D Level among the Patients with Alopecia Areata in a Tertiary Care Hospital, Bangladesh
People with alopecia areata have much lower Vitamin-D levels than healthy individuals.
research Molecular cloning of two novel types of peptidylarginine deiminase cDNAs from retinoic acid‐treated culture of a newborn rat keratinocyte cell line
Two new enzymes, PAD-R11 and PAD-R4, were cloned and showed activity, with PAD-R11 resembling epidermal enzymes.
research Identification of N6-Methyladenosine-Related Factors and the Prediction of the Regulatory Mechanism of Hair Follicle Development in Rex and Hycole Rabbits
N6-methyladenosine affects hair follicle development differently in Rex and Hycole rabbits.
research Effects of mitotane treatment on human steroid metabolism: implications for patient management
Mitotane changes steroid breakdown, affecting cortisol availability.
research Up-regulation of androgen receptor by heat shock protein 27 and miR-1 induces pathogenesis of androgenic alopecia.
Higher levels of heat shock protein 27 and lower levels of miR-1 can increase AR levels, leading to hair loss in men.
research Development of an aequorin-based assay for the screening of corticotropin-releasing factor receptor antagonists
The new assay can help develop products for hair re-growth.
research Congenital Adrenal Hyperplasia
Congenital Adrenal Hyperplasia is a rare inherited disease causing hormone imbalances, affecting growth, fertility, and heart health, diagnosed through blood tests and treated with medication and lifestyle changes.
research Decision letter: The molecular basis for ANE syndrome revealed by the large ribosomal subunit processome interactome
ANE syndrome is caused by a mutation in the RBM28 protein that disrupts ribosome assembly.
research ANALÝZA KORTIZOLU VO VLASOCH – BIOMARKER AKTIVÁCIE HPA OSI
Hair cortisol levels can effectively indicate long-term hormone activity.
research Assessing dutasteride-associated sexual dysfunction using the U.S. Food and Drug Administration Adverse Event Reporting System
Dutasteride is linked to a higher chance of sexual dysfunction, especially in younger males and the elderly.
research Abstract A12: Androgen receptor inhibition is involved in Finasteride-reduced AML cell proliferation
Finasteride reduces AML cell growth by inhibiting androgen receptors.
research Activation of cAMP Signaling in Response to α-Phellandrene Promotes Vascular Endothelial Growth Factor Levels and Proliferation in Human Dermal Papilla Cells
α-Phellandrene may help prevent hair loss by increasing growth factors and cell growth in hair cells through a specific signaling pathway.
research Topical spermine and putrescine stimulated DNA synthesis in the hairless mouse epidermis
Topical putrescine and spermine increased DNA synthesis in hairless mouse skin.
research Impact of dutasteride on spermatogenesis and oxidative status in rats.
Dutasteride did not change rat spermatogenesis or oxidative stress but needs more research.
research Mettl3-catalyzed m 6 A regulates histone modifier and modification expression in self-renewing somatic tissue
Mettl3 is essential for normal tissue development and self-renewal by regulating gene expression.
research Liquid Chromatography-Mass Spectrometry-Based In Vitro Metabolic Profiling Reveals Altered Enzyme Expressions in Eicosanoid Metabolism
The method reliably profiles eicosanoids and shows epitestosterone reduces their levels, similar to common anti-inflammatory drugs.
research Assessment of miR-19b-3p, miR-182-5p, and miR-155-5p expression and its relationship with alopecia areata severity
miR-155-5p can help diagnose and track alopecia areata severity.