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Type 3 5α-reductase is more common and finasteride and dutasteride strongly inhibit it.

848 genes related to fat and metabolism are less active in people with Central Centrifugal Cicatricial Alopecia.

Female mice with disrupted 5α-reductase 1 had significant metabolic issues, including stress response problems, insulin resistance, liver fat buildup, and obesity.

5α-reductase 2 is crucial for stress response in male rats.

Certain compounds, especially those with a propionic substituent, could potentially be new treatments for hair loss and similar disorders.

Four-amino acid part makes enzyme sensitive to finasteride.

Scientists made new substances that can block an enzyme linked to prostate issues and hair loss, with potential for creating a new treatment.

The human type II 5α-reductase gene, linked to certain male health conditions, has a specific structure and low similarity to other related genes.

The research helps understand how finasteride works and aids drug development.

Changing the C-ring structure in certain compounds can make them better at blocking a specific human enzyme.

The enzyme 5α-reductase is important for proper blood vessel development during the fertility-related transformation of the uterus lining.

Gene variant linked to prostate cancer, hormone levels, and hair loss.

A man with X-ALD improved after treatment, highlighting the need to consider X-ALD in similar patients and test their relatives.

5α-reductase enzyme affects hormone levels, influencing conditions like acne and hair loss.

SRD5A1 is crucial in advanced prostate cancer, and blocking both SRD5A1 and SRD5A2 is more effective than targeting SRD5A2 alone.

New compounds were made that effectively block a specific enzyme related to androgen conditions.

Accurate protein modeling can help develop new treatments for prostate cancer and other diseases.

All five human steroid 5α-reductase enzymes are found in the endoplasmic reticulum.

The research gives new understanding on how human steroid 5α-reductases work and how drugs like finasteride inhibit them, which could help in creating new drugs.

The enzyme 5α-reductase type 1 is important for blood vessel development and fertility in the uterus.

Gene differences may affect baldness treatment response in Korean men.

The enzyme Dgat1 is essential for healthy hair and skin by controlling retinoid levels.

The activity of a specific rat enzyme in the prostate and epididymis is highly dependent on the acidity level.

A 36-year-old person with a female appearance but male chromosomes was diagnosed with a rare enzyme deficiency affecting sexual development.

Benzo[c]quinolizin-3-ones are effective nonsteroidal inhibitors of human steroid 5α-reductase 1.

Type 2 5α-reductase plays a key role in hair loss.

2-Hydroxy-1,4-naphthoquinone is a strong 5α-reductase inhibitor.

Compounds 15, 20, and 25 are strong inhibitors of human steroid 5α-reductase type 2.