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Scientists made new substances that can block an enzyme linked to prostate issues and hair loss, with potential for creating a new treatment.

Finding functions for unknown GPCRs is hard but key for making new drugs.

Removing part of the vitamin D receptor stops vitamin D from working properly.

Three new gene mutations cause rickets and hair loss, treatable with high calcium and calcidol, but hair regrowth is rare.

Blocking mTORC1 reduces skin tumor growth in mice.

Females with 5 alpha-reductase-2 deficiency have less body hair, no acne, normal fertility, and delayed menarche.

RORs may influence cashmere growth cycles.

PRX01, PRX44, and PRX73 are essential for root hair growth in Arabidopsis thaliana.

DPR can show different hair characteristics, as seen in two brothers with normal hair.

Researchers identified promising inhibitors for the BRD4 protein, including finasteride and amentoflavone.

Steroidogenic isoenzymes may help improve treatments for common hair loss.

Fadrozole and Finasteride change frog sex ratios and cause intersex animals with altered gene expressions.

Mutations in the DSG4 gene cause fragile, sparse hair in humans, mice, and rats.

ROR2 is essential for hair follicle stem cell renewal and maintenance.

New indole-based compounds, particularly cemtirestat, show promise as dual-function drugs for diabetic complications.

A new DSG4 gene mutation causes hair defects in a young girl.

Scientists created cell lines to study a genetic skin disorder using CRISPR technology.

Newly designed proteins can effectively degrade specific proteins in cells, offering a potential new therapy method.

Prostaglandin D2 increases testosterone production in skin cells through a process involving reactive oxygen species, which could be a new target for treating hair loss and other skin conditions driven by testosterone.

The compounds tested could potentially treat hair loss and alopecia.

Keratin-associated proteins may have roles in various mouse tissues, not just hair.

FTase and GGTase-I are essential for skin keratinocyte health.

New mutations in the VDR gene cause vitamin D-resistant rickets without hair loss.

Different PADI isoforms help cells develop diverse functions.

The KRTAP7-1 gene is very similar across different cattle and yak breeds and likely plays a role in hair strength and shape.

The protein RSL4 is crucial for making root hairs longer by controlling genes related to cell growth.

The document reports findings on genetic research, including ethical concerns about genome editing, improved diagnosis of mitochondrial mutations, solving inherited eye diseases, confirming gene roles in epilepsy, linking a gene to aneurysms, and identifying genes associated with age-related macular degeneration.