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research Rational Design and Synthesis of 4-((1R,2R)-2-Hydroxycyclohexyl)-2(trifluoromethyl)benzonitrile (PF-998425), a Novel, Nonsteroidal Androgen Receptor Antagonist Devoid of Phototoxicity for Dermatological Indications

23 citations , October 2008 in “Journal of medicinal chemistry”

PF-998425 is a new, effective, and non-phototoxic treatment for skin conditions related to androgens.

research Association of prior 5-α-reductase inhibitor exposure with ICI benefit in metastatic RCC: Multicentre cohort with single-cell immune profiling.

March 2026 in “Journal of Clinical Oncology”

Using 5-α-reductase inhibitors before treatment improves outcomes for patients with metastatic renal cell carcinoma.

DKK2 and SOSTDC1 Cooperate to Initiate the First Catagen Phase of the Hair Follicle Growth Cycle

research 1428 DKK2 and SOSTDC1 cooperate to initiate the first catagen phase of the hair follicle growth cycle

April 2023 in “The journal of investigative dermatology/Journal of investigative dermatology”

DKK2 and SOSTDC1 together are necessary for the normal timing of the first regression phase in the hair growth cycle.

Ranitidine And Finasteride Inhibit The Synthesis And Release Of Trimethylamine N-Oxide And Mitigate Its Cardiovascular And Renal Damage Through Modulating Gut Microbiota

research Ranitidine and finasteride inhibit the synthesis and release of trimethylamine N-oxide and mitigates its cardiovascular and renal damage through modulating gut microbiota

14 citations , January 2020 in “International Journal of Biological Sciences”

Ranitidine and finasteride lower TMAO levels, reducing heart and kidney damage by changing gut bacteria.

research First-in-human phase 1 study of ETC-159 an oral PORCN inhbitor in patients with advanced solid tumours.

33 citations , May 2017 in “Journal of Clinical Oncology”

ETC-159 was safe up to 30 mg, but no tumor shrinkage was seen.

Hereditary Vitamin D Resistant Rickets (HVDRR) Case Series: Phenotype, Genotype, Conventional Treatment, and Adjunctive Cinacalcet Therapy

research Hereditary vitamin D resistant rickets (HVDRR) case series: phenotype, genotype, conventional treatment, and adjunctive cinacalcet therapy

1 citations , January 2024 in “Pediatric Endocrinology Diabetes and Metabolism”

Cinacalcet may help treat hereditary vitamin D resistant rickets safely.

Long Non-Coding RNA AL136131.3 Inhibits Hair Growth Through Mediating Glycolysis in Androgenetic Alopecia

research ISID1394 - Long non-coding RNA AL136131.3 inhibits hair growth through mediating glycolysis in androgenetic alopecia

May 2023

The RNA AL136131.3 slows down hair growth and speeds up hair loss by affecting sugar breakdown in hair follicles.

Genetics and Pathophysiology of Congenital Adrenal Hyperplasia

research Genetics and Pathophysiology of Congenital Adrenal Hyperplasia

July 2017 in “Contemporary Endocrinology”

The document concludes that patient outcomes for Congenital Adrenal Hyperplasia are often not ideal because of poor management and a need for better diagnosis and treatment methods.

research Clinical, biochemical and mutational findings in biotinidase deficiency among Malaysian population

8 citations , December 2019 in “Molecular genetics and metabolism reports”

Some children in Malaysia with symptoms have either profound or partial biotinidase deficiency, and early testing and treatment are important.

research 547 CDK9 Kinase Activation in Association with AFF1-SEC Initiate Epidermal Progenitor differentiation

November 2022 in “Journal of Investigative Dermatology”

NCSTN gene mutation causes abnormal skin cell differentiation and more inflammation, contributing to Hidradenitis Suppurativa.

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