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,
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,
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,
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,
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417 citations
,
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,
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,
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,
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356 citations
,
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350 citations
,
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343 citations
,
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330 citations
,
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324 citations
,
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316 citations
,
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310 citations
,
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308 citations
,
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,
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,
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291 citations
,
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284 citations
,
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277 citations
,
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256 citations
,
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243 citations
,
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242 citations
,
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240 citations
,
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239 citations
,
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239 citations
,
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237 citations
,
June 2013 in “Nature Medicine” A protein from certain immune cells is key for new hair growth after skin injury in mice.
236 citations
,
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235 citations
,
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