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Anti-Androgenic and Hair Growth Promoting Activities of Lygodii Spora (Spore of Lygodium Japonicum): Active Constituents Inhibiting Testosterone 5α-Reductase

research Anti-androgenic and Hair Growth Promoting Activities of Lygodii Spora (Spore of Lygodium japonicum) I. Active Constituents Inhibiting Testosterone 5.ALPHA.-Reductase.

38 citations , January 2002 in “Biological & Pharmaceutical Bulletin”

Lygodii Spora extract may help treat hair loss by blocking a hair loss-related enzyme and promoting hair growth.

research Finasteride: the first 5 alpha-reductase inhibitor.

34 citations , July 1993 in “PubMed”

research Sexual dimorphism of growth plate prehypertrophic and hypertrophic chondrocytes in response to testosterone requires metabolism to dihydrotestosterone (DHT) by steroid 5‐alpha reductase type 1

27 citations , February 2005 in “Journal of Cellular Biochemistry”

Male cells need DHT to respond to testosterone, while female cells do not.

research Inhibition of steroid 5 alpha-reductase with finasteride: sleep-related erections, potency, and libido in healthy men

14 citations , June 1995 in “The Journal of Clinical Endocrinology and Metabolism”

research Anti-androgenic curcumin analogues as steroid 5-alpha reductase inhibitors

12 citations , March 2017 in “Medicinal Chemistry Research”

Some curcumin-like compounds can effectively and safely block the enzyme linked to hair loss and other conditions related to male hormones.

research Discovery of Natural Steroid 5 Alpha-Reductase Inhibitors

11 citations , December 2018 in “Assay and Drug Development Technologies”

Natural herbal compounds might treat certain medical conditions by reducing DHT levels, but more research is needed to confirm their effectiveness and safety.

Effect of MK-386, a Novel Inhibitor of Type 1 5 Alpha-Reductase, Alone and in Combination with Finasteride, on Serum Dihydrotestosterone Concentrations in Men

research Effect of MK-386, a novel inhibitor of type 1 5 alpha-reductase, alone and in combination with finasteride, on serum dihydrotestosterone concentrations in men.

6 citations , August 1996 in “The Journal of Clinical Endocrinology and Metabolism”

MK-386 and finasteride together effectively reduce DHT levels, potentially treating acne and male pattern baldness.

research Finasteride and the 5-Alpha Reductase Inhibitors

October 2025 in “CRC Press eBooks”

research The use of 5 alpha-reductase in the era of minimally invasive surgical therapies (MISTs): Is it still valuable?

September 2024 in “Uro-Technology Journal”

research Expression and Activity Assay of Human Steroid 5 Alpha-Reductase Type II in CHO Cells

January 2004 in “Pharmaceutical biotechnology”

Finasteride effectively inhibits the enzyme steroid 5 alpha-reductase II.

research Dihydrotestosterone and the Concept of 5α–Reductase Inhibition in Human Benign Prostatic Hyperplasia

184 citations , January 2000 in “European Urology”

Blocking the enzyme that turns testosterone into DHT can safely and effectively treat enlarged prostate.

research Determination of the potency of a novel saw palmetto supercritical CO2 extract (SPSE) for 5α-reductase isoform II inhibition using a cell-free in vitro test system

2 citations , April 2016 in “DOAJ (DOAJ: Directory of Open Access Journals)”

The saw palmetto extract effectively inhibits an enzyme linked to prostate issues, showing promise for prostate health.

research Clinical and hormonal effects of the 5 alpha-reductase inhibitor finasteride in idiopathic hirsutism

17 citations , October 1994 in “The Journal of Clinical Endocrinology and Metabolism”

Theoretical Evaluation of Interaction of Some Dibenzo Derivatives on Both Androgen Receptor and 5-Alpha-Reductase Enzyme

research Theoretical evaluation of interaction of some dibenzo derivatives on both androgen receptor and 5α-reductase enzyme

5 citations , January 2022 in “Clinical cancer investigation journal”

Certain Dibenzo derivatives may help treat prostate cancer.

research Increased scalp skin and serum 5 alpha-reductase reduced androgens in a man relevant to the acquired progressive kinky hair disorder and developing androgenetic alopecia

2 citations , September 1997 in “Archives of Dermatology”

research Relative efficacy of minoxidil and 5-alpha-reductase inhibitors in the treatment of male androgenetic alopecia: protocol for a network meta-analysis study

1 citations , May 2021

research Supplemental Materials for "No Increased Cardiovascular Hazard with Oral 5-Alpha-Reductase Inhibitors in Treatment of Androgenetic Alopecia: A TriNetX Retrospective Cohort Study"

May 2026 in “Mendeley Data”

research Supplemental Materials for "No Increased Cardiovascular Hazard with Oral 5-Alpha-Reductase Inhibitors in Treatment of Androgenetic Alopecia: A TriNetX Retrospective Cohort Study"

May 2026 in “Mendeley Data”

research Supplemental Materials for "No Increased Cardiovascular Hazard with Oral 5-Alpha-Reductase Inhibitors in Treatment of Androgenetic Alopecia: A TriNetX Retrospective Cohort Study"

April 2026 in “Mendeley Data”

research Reduced Prostate Cancer Risk in Patients with Androgenetic Alopecia Using 5-Alpha Reductase Inhibitors: A TriNetX Real-World Cohort Study

March 2026 in “Journal of the American Academy of Dermatology”

research Re: A Review of the FAERS Data on 5-Alpha Reductase Inhibitors: Implications for Post-Finasteride Syndrome

September 2018 in “The Journal of Urology”

research The effect of finasteride, a 5 alpha-reductase inhibitor, on scalp skin testosterone and dihydrotestosterone concentrations in patients with male pattern baldness

61 citations , September 1994 in “The Journal of Clinical Endocrinology and Metabolism”

research Effect of finasteride, a 5 alpha-reductase inhibitor, on serum gonadotropins in normal men

9 citations , August 1992 in “The Journal of Clinical Endocrinology and Metabolism”

research Psychiatric Comorbidity Related to the Therapy of Male Androgenetic Alopecia Independent of the 5–Alpha Reductase Pathway

October 2021 in “Skin appendage disorders”

research Effect of MK-386, a novel inhibitor of type 1 5 alpha-reductase, alone and in combination with finasteride, on serum dihydrotestosterone concentrations in men

7 citations , August 1996 in “The Journal of Clinical Endocrinology and Metabolism”

research Inhibitors of 5α-Reductase in the Treatment of Benign Prostatic Hyperplasia

52 citations , February 2006 in “Current pharmaceutical design”

5α-reductase inhibitors and alpha-1 adrenergic antagonists together effectively treat benign prostatic hyperplasia, with long-term benefits.

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Products matching "alpha reductase"

Research

research Anti-androgenic and Hair Growth Promoting Activities of Lygodii Spora (Spore of Lygodium japonicum) I. Active Constituents Inhibiting Testosterone 5.ALPHA.-Reductase.

research Finasteride: the first 5 alpha-reductase inhibitor.

research Sexual dimorphism of growth plate prehypertrophic and hypertrophic chondrocytes in response to testosterone requires metabolism to dihydrotestosterone (DHT) by steroid 5‐alpha reductase type 1

research Inhibition of steroid 5 alpha-reductase with finasteride: sleep-related erections, potency, and libido in healthy men

research Anti-androgenic curcumin analogues as steroid 5-alpha reductase inhibitors

research Discovery of Natural Steroid 5 Alpha-Reductase Inhibitors

research Effect of MK-386, a novel inhibitor of type 1 5 alpha-reductase, alone and in combination with finasteride, on serum dihydrotestosterone concentrations in men.

research Finasteride and the 5-Alpha Reductase Inhibitors

research The use of 5 alpha-reductase in the era of minimally invasive surgical therapies (MISTs): Is it still valuable?

research Expression and Activity Assay of Human Steroid 5 Alpha-Reductase Type II in CHO Cells

research Dihydrotestosterone and the Concept of 5α–Reductase Inhibition in Human Benign Prostatic Hyperplasia

research Determination of the potency of a novel saw palmetto supercritical CO2 extract (SPSE) for 5α-reductase isoform II inhibition using a cell-free in vitro test system

research Clinical and hormonal effects of the 5 alpha-reductase inhibitor finasteride in idiopathic hirsutism

research Theoretical evaluation of interaction of some dibenzo derivatives on both androgen receptor and 5α-reductase enzyme

research Increased scalp skin and serum 5 alpha-reductase reduced androgens in a man relevant to the acquired progressive kinky hair disorder and developing androgenetic alopecia

research Relative efficacy of minoxidil and 5-alpha-reductase inhibitors in the treatment of male androgenetic alopecia: protocol for a network meta-analysis study

research 0192 Estrogenic effects of 5-alpha-reductase inhibitors in male androgenetic alopecia patients

research Crystal structure of Steroid 5-alpha-reductase 2 in complex with Finasteride

research Abietic Acid from Resina Pini of Pinus Species as a Testosterone 5.ALPHA.-Reductase Inhibitor

research Risk of estrogen-driven malignancies in females on 5-alpha reductase inhibitors

research Supplemental Materials for "No Increased Cardiovascular Hazard with Oral 5-Alpha-Reductase Inhibitors in Treatment of Androgenetic Alopecia: A TriNetX Retrospective Cohort Study"

research Supplemental Materials for "No Increased Cardiovascular Hazard with Oral 5-Alpha-Reductase Inhibitors in Treatment of Androgenetic Alopecia: A TriNetX Retrospective Cohort Study"

research Supplemental Materials for "No Increased Cardiovascular Hazard with Oral 5-Alpha-Reductase Inhibitors in Treatment of Androgenetic Alopecia: A TriNetX Retrospective Cohort Study"

research Reduced Prostate Cancer Risk in Patients with Androgenetic Alopecia Using 5-Alpha Reductase Inhibitors: A TriNetX Real-World Cohort Study

research Re: A Review of the FAERS Data on 5-Alpha Reductase Inhibitors: Implications for Post-Finasteride Syndrome

research The effect of finasteride, a 5 alpha-reductase inhibitor, on scalp skin testosterone and dihydrotestosterone concentrations in patients with male pattern baldness

research Effect of finasteride, a 5 alpha-reductase inhibitor, on serum gonadotropins in normal men

research Psychiatric Comorbidity Related to the Therapy of Male Androgenetic Alopecia Independent of the 5–Alpha Reductase Pathway

research Effect of MK-386, a novel inhibitor of type 1 5 alpha-reductase, alone and in combination with finasteride, on serum dihydrotestosterone concentrations in men

research Inhibitors of 5α-Reductase in the Treatment of Benign Prostatic Hyperplasia