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Rationale and Design of a Novel, Phase 3, External and Synthetic Placebo-Controlled Clinical Trial of Ritlecitinib 50 mg and 100 mg for Alopecia Areata

research Rationale and Design of a Novel, Phase 3, External and Synthetic Placebo-Controlled Clinical Trial of Ritlecitinib 50 mg and 100 mg for Alopecia Areata

October 2025 in “Dermatology and Therapy”

Ritlecitinib is being tested for effectiveness and safety in treating severe alopecia areata.

research Aryl hydrocarbon receptor overexpression in miniaturized follicles in female pattern hair loss

4 citations , June 2017 in “Anais Brasileiros De Dermatologia”

Aryl hydrocarbon receptor overexpression found in miniaturized hair follicles in female hair loss.

research Mechanism of progesterone neuroprotection of rat cerebellar Purkinje cells following oxygen–glucose deprivation

83 citations , November 2006 in “European Journal of Neuroscience”

Progesterone protects rat brain cells by enhancing GABA A receptor activity.

research Spironolactone versus Bicalutamide in female pattern hair loss: A randomised clinical trial

February 2026 in “Clinical and Experimental Dermatology”

Bicalutamide improved hair growth more than spironolactone in women with hair loss.

research Germline Mutation in ATR in Autosomal- Dominant Oropharyngeal Cancer Syndrome

71 citations , February 2012 in “The American Journal of Human Genetics”

A specific ATR gene mutation is linked to a hereditary oropharyngeal cancer syndrome.

research Androgenetic alopecia risk IDed with genetic test

April 2010 in “Dermatology Times”

research Effects of Flutamide, a pure antiandrogen, on endocrine parameters, in the adult female rat

8 citations , January 1987 in “Gynecological Endocrinology”

Flutamide, an antiandrogen, has minimal impact on female rat endocrine systems and does not significantly change their reproductive cycles.

research Relative binding affinity of novel steroids to androgen receptors in hamster prostate

5 citations , January 2005 in “Journal of Enzyme Inhibition and Medicinal Chemistry”

New steroids were effective in blocking male hormone receptors in hamster prostates.

research Problems in evaluating chronic toxicity of contraceptive steroids in dogs

25 citations , September 1977 in “Journal of Toxicology and Environmental Health”

High doses of some contraceptive steroids cause health issues in dogs, but their relevance to humans is unclear.

research Is dehydroepiandrosterone a hormone?

403 citations , November 2005 in “Journal of Endocrinology”

Dehydroepiandrosterone (DHEA) is a prohormone important for producing sex steroids and has potential health benefits.

research Thrombin activatable fibrinolysis inhibitor and other hemostatic parameters in patients with polycystic ovary syndrome

29 citations , January 2009 in “Gynecological Endocrinology”

Women with PCOS have higher levels of certain blood clotting factors, suggesting a greater risk of cardiovascular issues.

research Gene-wide association study between the aromatase gene (CYP19A1) and female pattern hair loss

77 citations , April 2009 in “British Journal of Dermatology”

Aromatase gene variation may increase female hair loss risk.

research BIOCHEMICAL AND HORMONAL FACTORS IN THE DEVELOPMENT OF ALOPECIA IN WOMEN: DIAGNOSTIC SIGNIFICANCE FOR TRICHOLOGICAL PRACTICE

April 2026 in “Academia Polonica.”

Alopecia in women can signal broader health issues and requires a thorough diagnosis to tailor treatments.

research Integrated Safety Analysis of Ritlecitinib for the Treatment of Alopecia Areata (AA) From the Phase 2 and Phase 3 ALLEGRO Clinical Trial Program

4 citations , November 2023 in “SKIN The Journal of Cutaneous Medicine”

The integrated safety analysis of ritlecitinib, a JAK3/TEC family kinase inhibitor, for the treatment of alopecia areata (AA) was conducted using data from four studies within the ALLEGRO clinical trial program. The analysis included a placebo-controlled pool of 881 patients for up to 24 weeks and an all-exposure pool of 1,294 patients for up to 36 months. Participants were aged 12 years and older, with at least 25% scalp hair loss, and were not receiving other AA treatments. The study evaluated various doses of ritlecitinib, including 10 mg, 30 mg, 50 mg, and combinations with a 200 mg loading dose. Safety data were summarized using counts and percentages of adverse events and lab abnormalities, with incidence rates adjusted for study size reported per 100 patient-years. The findings support the safety of ritlecitinib for up to 48 weeks in treating AA.

research Co-expression of PADI isoforms during progenitor differentiation enables functional diversity

2 citations , October 2023 in “Philosophical Transactions of the Royal Society B Biological Sciences”

Different PADI isoforms help cells develop diverse functions.

research Circulating testosterone and feather-gene expression of receptors and metabolic enzymes in relation to melanin-based colouration in the barn owl

14 citations , September 2017 in “General and comparative endocrinology”

Barn owls with smaller black spots have higher testosterone levels, which might be due to genetic effects on hormone regulation rather than hormone effects on coloration.

2,3,7,8-Tetrachlorodibenzo-p-dioxin Increases the Expression of Genes in the Human Epidermal Differentiation Complex and Accelerates Epidermal Barrier Formation

research 2,3,7,8-Tetrachlorodibenzo-p-dioxin Increases the Expression of Genes in the Human Epidermal Differentiation Complex and Accelerates Epidermal Barrier Formation

86 citations , August 2011 in “Toxicological sciences”

TCDD speeds up skin barrier formation by increasing certain gene expressions.

research Basics of androgen synthesis and action

35 citations , May 2022 in “Baillière's best practice and research in clinical endocrinology and metabolism/Baillière's best practice & research. Clinical endocrinology & metabolism”

Androgens like testosterone are important hormones for both men and women, made differently in each sex and affecting the body by regulating genes and quick interactions with cell components.

research Outcomes in Clinically Relevant Patient Subgroups From the EMBRACA Study: Talazoparib vs Physician’s Choice Standard-of-Care Chemotherapy

26 citations , October 2019 in “JNCI Cancer Spectrum”

Talazoparib is more effective than standard chemotherapy for advanced breast cancer with BRCA mutations.

research Monilethrix unveiled by initial androgenetic alopecia.

June 2011 in “European Journal of Pediatric Dermatology”

An 11-year-old girl with hair thinning was diagnosed with monilethrix and early androgenetic alopecia.

Clinical and Phototrichogrammatic Evaluation of Estradiol Replacement Therapy on Hair Growth in Postmenopausal Japanese Women with Female Pattern Hair Loss: A Pilot Study

research Clinical and phototrichogrammatic evaluation of estradiol replacement therapy on hair growth in postmenopausal Japanese women with female pattern hair loss: a pilot study

November 2023 in “International Journal of Women's Dermatology”

Hormone replacement therapy may improve hair growth in the frontal hairline of postmenopausal women with hair loss.

Retinoid-Mediated Stimulation of Steroid Sulfatase Activity in Myeloid Leukemic Cell Lines Requires RARα and RXR and Involves the Phosphoinositide 3-Kinase and ERK-MAP Kinase Pathways

research Retinoid-mediated stimulation of steroid sulfatase activity in myeloid leukemic cell lines requires RARα and RXR and involves the phosphoinositide 3-kinase and ERK-MAP kinase pathways

24 citations , September 2005 in “Journal of Cellular Biochemistry”

Retinoids increase steroid sulfatase activity in leukemia cells through RARα/RXR and involves certain pathways like phosphoinositide 3-kinase and ERK-MAP kinase.

12-O-Tetradecanoylphorbol-13-Acetate Induces Apoptosis in Renal Epithelial Cells Through a Growth Signal Conflict Prevented by Activated Ras

research 12-O-Tetradecanoylphorbol-13-acetate Induces Apoptosis in Renal Epithelial Cells through a Growth Signal Conflict Which Is Prevented by Activated ras1

4 citations , January 2001 in “Archives of Biochemistry and Biophysics”

Activated ras can protect kidney cells from a certain substance that causes cell death.

research Updated Integrated Safety Analysis of Ritlecitinib up to ~5 Years in Adolescents With Alopecia Areata From the ALLEGRO Clinical Trials

November 2025 in “SKIN The Journal of Cutaneous Medicine”

Ritlecitinib is generally safe for adolescents with alopecia areata over 5 years.

research Modern approach to the treatment of patients with androgen-dependent dermatopathies

October 2021 in “Meditsinskiy sovet = Medical Council”

Cyproterone acetate improves skin symptoms and quality of life in women with androgen-related issues.

research Natural Product-InspiredBis(trifluoromethyl) PhenylHydroxycinnamate Derivatives as Promising Nonsteroidal Inhibitorsof Human Steroid 5α-Reductase Type-1: Synthesis, InVitro, and In Silico Studies

August 2025 in “OPAL (Open@LaTrobe) (La Trobe University)”

Certain hydroxycinnamate derivatives may effectively inhibit enzymes linked to hair loss with low toxicity.

Novel Lead Generation Through Hypothetical Pharmacophore Three-Dimensional Database Searching: Discovery of Isoflavonoids as Nonsteroidal Inhibitors of Rat 5α-Reductase

research Novel Lead Generation through Hypothetical Pharmacophore Three-Dimensional Database Searching: Discovery of Isoflavonoids as Nonsteroidal Inhibitors of Rat 5α-Reductase

27 citations , October 2001 in “Journal of Medicinal Chemistry”

Researchers found new potential but less potent rat enzyme inhibitors using a 3D model.

Hormonal Control Of 5 Alpha-Reductase Activity In Hamster Sebaceous Glands

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