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Novel ALK5 Inhibitor TP0427736 Reduces TGF-β Induced Growth Inhibition in Human Outer Root Sheath Cells and Elongates Anagen Phase in Mouse Hair Follicles

research Novel ALK5 inhibitor TP0427736 reduces TGF-β induced growth inhibition in human outer root sheath cells and elongates anagen phase in mouse hair follicles

14 citations , January 2017 in “Pharmacological Reports”

TP0427736 may help treat hair loss by blocking a specific protein and promoting hair growth.

research Inhibition of Bmp signaling affects growth and differentiation in the anagen hair follicle

305 citations , December 2000 in “The EMBO Journal”

Inhibiting Bmp signaling disrupts hair growth and differentiation.

research Message of nexin 1, a serine protease inhibitor, is accumulated in the follicular papilla during anagen of the hair cycle

37 citations , December 1995 in “Journal of Cell Science”

Nexin 1 may help control hair growth.

research Leptin of dermal adipose tissue is differentially expressed during the hair cycle and contributes to adipocyte‐mediated growth inhibition of anagen‐phase vibrissa hair

30 citations , October 2014 in “Experimental Dermatology”

Leptin from skin fat can slow hair growth during certain phases.

Promotion of Anagen, Increased Hair Density, and Reduction of Hair Fall in a Clinical Setting Following Identification of FGF5-Inhibiting Compounds via a Novel 2-Stage Process

research Promotion of anagen, increased hair density and reduction of hair fall in a clinical setting following identification of FGF5-inhibiting compounds via a novel 2-stage process

27 citations , February 2017 in “Clinical, Cosmetic and Investigational Dermatology”

New compounds were found to help increase hair growth and decrease hair loss.

research HNG, A Humanin Analogue, Promotes Hair Growth by Inhibiting Anagen-to-Catagen Transition

13 citations , June 2020 in “International Journal of Molecular Sciences”

HNG helps hair grow by keeping hair in the growth phase longer.

18-β-Glycyrrhetinic Acid Promotes Hair Growth by Stimulating the Proliferation of Dermal Papilla Cells and Outer Root Sheath Cells, and Extends the Anagen Phase by Inhibiting 5α-Reductase

research 18-β-Glycyrrhetinic Acid Promotes Hair Growth by Stimulating the Proliferation of Dermal Papilla Cells and Outer Root Sheath Cells, and Extends the Anagen Phase by Inhibiting 5α-Reductase

July 2024 in “Biological and Pharmaceutical Bulletin”

Licorice extract helps hair growth and may treat hair loss.

research Pharmacologic inhibition of JAK-STAT signaling promotes hair growth

159 citations , October 2015 in “Science Advances”

Blocking JAK-STAT signaling can lead to hair growth.

Identifying Novel Strategies for Treating Human Hair Loss Disorders: Cyclosporine A Suppresses the Wnt Inhibitor, SFRP1, in the Dermal Papilla of Human Scalp Hair Follicles

research Identifying novel strategies for treating human hair loss disorders: Cyclosporine A suppresses the Wnt inhibitor, SFRP1, in the dermal papilla of human scalp hair follicles

68 citations , May 2018 in “PLOS Biology”

Cyclosporine A may help treat hair loss by blocking a protein that inhibits hair growth.

The Effect of Cilostazol, a Phosphodiesterase 3 (PDE3) Inhibitor, on Human Hair Growth with Dual Promoting Mechanisms

research The effect of cilostazol, a phosphodiesterase 3 (PDE3) inhibitor, on human hair growth with the dual promoting mechanisms

21 citations , April 2018 in “Journal of Dermatological Science”

Cilostazol helps hair grow by making hair root cells grow faster and changing growth factor levels.

research Expression of matrix metalloproteinases and tissue inhibitor of matrix metalloproteinases in the hair cycle

21 citations , May 2016 in “Experimental and Therapeutic Medicine”

MMP-2 and MMP-9 help hair grow, while their inhibitors peak when hair growth slows.

research Topical Inhibition of the Electron Transport Chain Can Stimulate the Hair Cycle

11 citations , October 2017 in “Journal of Investigative Dermatology”

Applying certain inhibitors to the skin can promote hair growth without harming cells.

research Inhibition of Rab27a and Rab27b Has Opposite Effects on the Regulation of Hair Cycle and Hair Growth

3 citations , August 2020 in “International Journal of Molecular Sciences”

Blocking Rab27a slows hair growth, while blocking Rab27b encourages it.

Studies on the Effect of Sophora Flavescens Extract on Hair Growth Stimulation and Acne Inhibition

research Studies on the effect of Sophora flavescens extract on the hair growth stimulation and acne inhibition

2 citations , January 2002 in “The Journal of Korean Medicine Ophthalmology and Otolaryngology and Dermatology”

Sophora flavescens extract helps hair grow and prevents acne.

Tyrosine Kinase 2 Inhibition Ameliorates the Phenotype of Lesional Alopecia Areata Scalp Skin Ex Vivo, and Reverses the Induction of Human Alopecia Areata in a Humanized Mouse Model

research 014 Tyrosine Kinase 2 Inhibition Ameliorates the Phenotype of Lesional Alopecia Areata Scalp Skin Ex Vivo, and Reverses the Induction of Human Alopecia Areata in a Humanized Mouse Model

November 2022 in “The journal of investigative dermatology/Journal of investigative dermatology”

TYK2 inhibition may help treat alopecia areata by promoting hair growth and reducing immune response.

research 755 Repurposing of DPP4 inhibition to improve hair follicle activation and regeneration

July 2022 in “Journal of Investigative Dermatology”

Blocking DPP4 can help activate hair growth and improve hair regeneration.

research 681 Inhibition of STAT3, using Oenocarpus bataua vegetable oil, on in vitro model

April 2016 in “Journal of Investigative Dermatology”

Oenocarpus bataua vegetable oil may help reduce hair loss by affecting a key gene pathway.

Preclinical Evidence Supporting Selective Inhibition of Tyrosine Kinase 2-Dependent, IL-12-Mediated Signaling as a Novel Strategy for Alopecia Areata Management

research 27 Preclinical ex vivo and in vivo evidence supporting selective inhibition of tyrosine kinase 2-dependent, IL-12-mediated signaling as a novel pharmacological strategy for alopecia areata management

November 2023 in “The journal of investigative dermatology/Journal of investigative dermatology”

Blocking TYK2 might be a new way to treat hair loss from alopecia areata.

research A case report of inflammatory nonscarring alopecia associated with the epidermal growth factor receptor inhibitor erlotinib

33 citations , June 2009 in “Journal of Cutaneous Pathology”

Erlotinib can cause nonscarring hair loss and itchy skin.

research The effects of phosphodiesterase 3 (PDE3) inhibitor on hair follicle cell viability and hair growth

1 citations , January 2020 in “Seoul National University Open Repository (Seoul National University)”

PDE3 inhibitor may help treat hair loss by promoting hair growth.

research 845 Dermal lymphatic vessels promote hair follicle growth via the BMP inhibitor Sostdc1

April 2017 in “Journal of Investigative Dermatology”

Dermal lymphatic vessels help hair growth by affecting hair cycle phases.

research Repurposing DPP4-Inhibition to Improve Hair Follicle Activation and Regeneration

May 2023 in “Journal of Investigative Dermatology”

Blocking DPP4 can potentially speed up hair growth and regeneration, especially after injury or in cases of hair loss.

research Hair growth inhibition by heparin in mice: a model system for studying the modulation of epithelial cell growth by glycosaminoglycans?

46 citations , May 1991 in “British Journal of Dermatology”

Heparin can inhibit hair growth in mice when injected.

research Inhibition of prolactin promotes secondary skin follicle activation in cashmere goats

7 citations , March 2021 in “Journal of animal science/Journal of animal science ... and ASAS reference compendium”

Blocking prolactin increases the activity of secondary hair follicles in cashmere goats.

Glycogen Phosphorylase Inhibitor Promotes Hair Growth via Protecting from Oxidative Stress and Regulating Glycogen Breakdown in Human Hair Follicles

research Glycogen Phosphorylase Inhibitor Promotes Hair Growth via Protecting from Oxidative-Stress and Regulating Glycogen Breakdown in Human Hair follicles

August 2024 in “Biomolecules & Therapeutics”

A new compound, HTPI, promotes hair growth by protecting cells from damage and regulating energy use.

Alcohol Extract from Vernonia Anthelmintica Seed Counteracts Stress-Induced Murine Hair Follicle Growth Inhibition

research Alcohol extract from Vernonia anthelmintica willd (L.) seed counteracts stress-induced murine hair follicle growth inhibition

6 citations , December 2019 in “BMC Complementary and Alternative Medicine”

Alcohol extract from Vernonia anthelmintica seeds may help treat stress-related hair loss.

research 5-Fluorouracil induces hair loss by inhibiting β-catenin signaling and angiogenesis

February 2025 in “Chemico-Biological Interactions”

5-Fluorouracil causes hair loss by blocking signals needed for hair growth.

The Role of 5-Alpha-Reductase Inhibition in Suppressing Progression of Male Androgenetic Alopecia and the Potential Application of Saw Palmetto Extracts

research The role of 5-α-reductase inhibition in supressing progression of male androgenetic alopecia − a postulate for further studies on possible application of saw palmetto extracts

October 2023 in “Annales Academiae Medicae Silesiensis”

Saw palmetto extracts might help treat male hair loss and need more research.

research Stauntonia hexaphylla Extract Ameliorates Androgenic Alopecia by Inhibiting Androgen Signaling in Testosterone-induced Alopecia Mice

January 2023 in “Iranian Journal of Pharmaceutical Research”

Stauntonia hexaphylla extract can help treat hair loss by blocking certain hormones.

research Mesenchymal Stem Cells Antagonize IFN-Induced Proinflammatory Changes and Growth Inhibition Effects via Wnt/β-Catenin and JAK/STAT Pathway in Human Outer Root Sheath Cells and Hair Follicles

14 citations , April 2021 in “International journal of molecular sciences”

Mesenchymal stem cells may help treat hair loss by improving hair cell growth and reducing inflammation.