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The substance MK386 effectively blocked testosterone conversion and reduced cell growth in certain skin cells, but inhibiting 5α-reductase alone may not greatly improve acne.

Spironolactone, a heart and liver drug, has new uses including cancer treatment, viral infection prevention, and skin condition improvement.

Male mice with FGF5 mutations grow longer hair than females.

Hydroxychloroquine may help treat benign prostatic hyperplasia by reducing inflammation and promoting cell death.

Cernitin™, a pollen extract, was found to significantly reduce pain and inflammation in rats with chronic prostatitis, suggesting it could be a useful alternative to certain anti-inflammatory drugs.

Sper-12 nanoparticles may help treat hair loss by delivering siRNA to target androgen receptors.

Fenugreek extract may help treat benign prostatic hyperplasia.

The ABI1 gene contributes to prostate cancer progression and treatment resistance.

Low testosterone levels may lead to more severe COVID-19 outcomes.

Sapium rotundifolium extract may help treat enlarged prostate.

People with androgenetic alopecia may have a higher risk of severe COVID-19.

Testosterone stimulates growth in intermediate hair follicles, but this can be blocked by cyproterone acetate.

Knocking out the FGF5 gene in sheep increased wool production and hair-follicle density.

Six new genes linked to early hair loss were found, which also surprisingly connect to Parkinson's disease and lower fertility.

Six new genes linked to early hair loss were found, which also surprisingly connect to Parkinson's disease and lower fertility.

A specific metabolite, not a receptor protein, triggers the production of certain kidney enzymes, but this process is disrupted in mice with a mutation causing testicular feminization.

Balding scalps show different gene expressions affecting hair growth compared to non-balding scalps.

Human skin acts like a hormone-producing organ, making and managing various hormones important for skin and hair health.

Dihydrotestosterone causes p27 protein breakdown in ovarian and breast cancer cells by binding with SKP2.

Testosterone protects female heart cells from stress by activating estrogen receptors.

RE-ORGA, a Korean herb extract, may help prevent hair loss.

Testosterone increases certain kidney protein levels, potentially raising blood pressure.

PROTACs show promise for cancer treatment, but designing them effectively is challenging.

The exact cause of increased 5α-reductase activity leading to hirsutism in women is still unknown.

Different substances that activate or block the androgen receptor can affect male development and treat conditions like prostate cancer.

Men with hair loss have more DNA changes in back-of-head hair follicles, possibly protecting them from thinning.

Androgen receptors are key for development and health, affecting conditions like prostate cancer and male pattern baldness.

The length of the CAG repeat in the androgen receptor gene affects the risk and progression of prostate cancer, BPH, infertility, and undermasculinized genitalia.

Certain changes to the B-ring of androgen receptor ligands can increase their effectiveness for potential treatments of muscle and bone conditions.

Spironolactone harms fish reproduction and is more potent in fish than invertebrates, needing environmental monitoring.