Search

for
Search:

Did you mean Androgen-Dependent?

GlossaryAndrogen-Dependent

biological process influenced by male sex hormones

Androgen-dependent refers to biological processes or conditions that are influenced or regulated by androgens, which are male sex hormones like testosterone. For example, androgen-dependent hair loss, also known as androgenetic alopecia, occurs when hair follicles shrink due to the effects of these hormones, leading to thinning hair or baldness. This term is crucial in understanding conditions that are influenced by hormonal changes, particularly in the context of hair growth and loss.

Related Terms

Sort by

Research

30 / 1000+ results

Synthesis of Novel Androstane-N-Cyclohexyl-17-Carboxamides and Their Effect on 5α-Reductase Isoform 2, Androgen Receptor, and Androgen-Dependent Glands

research Synthesis of novel andostane-N-cyclohexyl-17-carboxamides, and their effect on the 5α-reductase isoform 2, the androgen receptor, and androgen-dependent glands

November 2021 in “Pharmaceutical Sciences”

New compounds were made and tested, with compound 6 showing potential for treating prostate-related diseases.

Androgens Affect the Activity of Human Sebocytes in Culture Depending on the Localization of the Sebaceous Glands, and Their Effect Is Antagonized by Spironolactone

research Androgens Affect the Activity of Human Sebocytes in Culture in a Manner Dependent on the Localization of the Sebaceous Glands and Their Effect Is Antagonized by Spironolactone

40 citations , January 1994 in “Skin Pharmacology and Physiology”

Male hormones affect oil-producing skin cells differently based on their body location, and the drug spironolactone can reduce these effects.

In Vitro and In Vivo Effects of 17β-N-(4-Phenylcarbamoyl) Androst-4-en-3-one Derivatives as 5α-Reductase Inhibitors on Androgen-Dependent Glands

research In vitro and In vivo Effects of 17β-N-(4-phenylcarbamoyl) androst-4-en-3- one Derivatives as 5a-reductase Inhibitors on Androgen-dependent Glands

September 2020 in “Current Enzyme Inhibition”

Three compounds were found to inhibit a prostate disease-related enzyme and reduce prostate size more effectively than the current treatment, suggesting they could be used for treating benign prostatic hyperplasia.

research The promoter of an androgen dependent gene in the hamster flank organ

6 citations , May 1997 in “Journal of Dermatological Science”

Researchers found a gene in hamsters that responds to male hormones and may be indirectly controlled by them.

Selective Induction of Apoptosis in the Hamster Flank Sebaceous Gland Organ by a Topical Liposome 5-Alpha-Reductase Inhibitor: A Treatment Strategy for Acne

research Selective induction of apoptosis in the hamster flank sebaceous gland organ by a topical liposome 5-α-reductase inhibitor: A treatment strategy for acne

8 citations , February 2010 in “Journal of Dermatology”

A topical treatment safely and effectively reduced acne by causing targeted cell death in sebaceous glands without side effects.

research The Rise in Adrenal Androgen Biosynthesis: Adrenarche

173 citations , November 2004 in “Seminars in Reproductive Medicine”

Adrenarche increases adrenal androgens around age 6, affecting hair growth and development.

research The Androgen Receptor Antagonizes Wnt/β-Catenin Signaling in Epidermal Stem Cells

46 citations , June 2015 in “Journal of Investigative Dermatology”

Androgen receptor activity blocks Wnt/β-catenin signaling, affecting hair growth and skin cell balance.

research New Nonsteroidal Molecules as Blockers of the Steroidogenic Pathway

January 2022 in “Current Enzyme Inhibition”

New nonsteroidal molecules can potentially increase dihydrotestosterone in neurons by blocking certain enzymes, without affecting prostate and seminal vesicle weight.

research Female Hirsutism: Pathophysiological Considerations and Therapeutic Implications*

53 citations , October 1984 in “Endocrine reviews”

Excessive hair growth in women often has no known cause and is not linked to race or other hormonal symptoms.

research Clascoterone: First Approval

27 citations , October 2020 in “Drugs”

Clascoterone cream was approved in the USA for treating acne in people aged 12 and older.

research Topical Minoxidil Does Not Act as an Antiandrogen in the Flank Organ of the Golden Syrian Hamster

26 citations , January 1987 in “Archives of Dermatology”

Topical minoxidil does not block androgen effects.

research Effects of In Utero Exposure to D-004, a Lipid Extract from Roystonea regia Fruits, in the Male Rat: A Comparison with Finasteride

8 citations , August 2011 in “Journal of Medicinal Food”

D-004 may be a natural alternative to finasteride for treating enlarged prostate and male baldness.

research 4th Intercontinental Meeting of Hair Research Societies 2004 The "World of Hair"

1 citations , May 2004 in “Journal der Deutschen Dermatologischen Gesellschaft”

The meeting presented new findings on hair stem cells, pigmentation, genetics, and modern hair treatment techniques.

research Organizational Effects of Estrogens and Androgens on Estrogen and Androgen Receptor Expression in Pituitary and Adrenal Glands in Adult Male and Female Rats

1 citations , June 2022 in “Frontiers in Neuroanatomy”

Early hormones shape sex-specific differences in rat glands.

research c-MYC-Induced Sebaceous Gland Differentiation Is Controlled by an Androgen Receptor/p53 Axis

60 citations , February 2013 in “Cell reports”

The balance between androgen receptor and p53 is crucial for sebaceous gland differentiation.

research Cutaneous Androgen Metabolism: Basic Research and Clinical Perspectives

233 citations , November 2002 in “The journal of investigative dermatology/Journal of investigative dermatology”

Creating stronger blockers for skin enzymes might lead to better treatment for conditions like acne and excessive hair growth.

research Is the metabolism of testosterone to 5α-dihydrotestosterone required for androgen action in the skin?

14 citations , November 1982 in “British Journal of Dermatology”

Testosterone conversion to 5α-DHT may not be essential for its effects on the skin.

research Pharmacologic Modulation of Sebaceous Gland Activity: Mechanisms and Clinical Applications

30 citations , April 2007 in “Dermatologic Clinics”

The document concludes that new treatments are needed to better manage acne and reduce side effects related to current therapies.

research Actions of isotretinoin and etretinate on the pilosebaceous unit

46 citations , April 1982 in “Journal of the American Academy of Dermatology”

Isotretinoin shrinks sebaceous glands without affecting hair or skin color, unlike etretinate.

research Acne

2 citations , May 2011 in “Harper's Textbook of Pediatric Dermatology”

Acne is a common skin condition linked to diet, hormones, and genetics, and early treatment can prevent scarring.

research Bioavailability File: Bicalutamide

August 2025 in “Fabad Journal of Pharmaceutical Sciences”

Bicalutamide effectively treats prostate cancer but needs careful monitoring for side effects.

Androgenic Alopecia: Characteristics and Perspectives

research Androgenic alopecia--Its characteristics and perspectives

January 1992 in “Juntendo Medical Journal”

Male pattern baldness is mainly caused by a hormone called dihydrotestosterone (DHT), and drugs that can block this hormone might help prevent hair loss.

research Effects of natural products on skin inflammation caused by abnormal hormones secreted by the adrenal gland

2 citations , May 2023 in “Frontiers in Pharmacology”

Natural products may help treat skin inflammation from abnormal adrenal hormones.

research Anti-androgenic effect of sesquiterpenes isolated from the rhizomes of Curcuma aeruginosa Roxb.

44 citations , March 2012 in “Fitoterapia”

Germacrone from Curcuma aeruginosa may help treat conditions related to male hormones by blocking a specific enzyme.

research Prolactin as a candidate sebotrop(h)ic hormone?

26 citations , March 2018 in “Experimental Dermatology”

Prolactin may influence skin glands and could be a target for treating acne and skin aging.