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GlossaryAndrogen-Related Conditions

health issues caused by male hormones like testosterone

Androgen-related conditions are health issues that arise due to the effects of androgens, which are male hormones like testosterone. These conditions can affect both men and women and include problems such as acne, hirsutism (excessive hair growth), and androgenic alopecia (pattern hair loss). In women, they can also be linked to polycystic ovary syndrome (PCOS), which can cause irregular menstrual cycles and fertility issues.

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Polycystic Ovary Syndrome and Other Androgen Excess-Related Conditions: Can Changes in Dietary Intake Make a Difference?

research Polycystic Ovary Syndrome (PCOS) and Other Androgen Excess–Related Conditions: Can Changes in Dietary Intake Make a Difference?

48 citations , February 2008 in “Nutrition in Clinical Practice”

Dietary changes, including weight loss and a balanced diet, are important for managing PCOS, especially in overweight women.

research Simultaneous quantitation of nine hydroxy-androgens and their conjugates in human serum by stable isotope dilution liquid chromatography electrospray ionization tandem mass spectrometry

22 citations , January 2017 in “Journal of steroid biochemistry and molecular biology/The Journal of steroid biochemistry and molecular biology”

A new method accurately measures nine specific hormones in human blood.

research Effects of the anti-androgen finasteride on 5alpha-reductase activity in human gingival fibroblasts in response to minocycline

15 citations , January 1998 in “Journal of Clinical Periodontology”

Finasteride helps treat hair loss by blocking enzyme activity.

research Hair and Scalp Variation Related to Gender

January 2018 in “Springer eBooks”

Gender affects hair and scalp characteristics, with differences in hormone responses, graying patterns, and trace metals.

research Do clinical markers of hyperandrogenism relate to the response of acne to conventional therapy?

January 1990 in “Journal of dermatological treatment”

Clinical features of hyperandrogenism do not predict the success of conventional acne treatment in women.

research Factors affecting the severity of central centrifugal cicatricial alopecia

29 citations , January 2016 in “International Journal of Dermatology”

Longer hair loss leads to more severe CCCA; early treatment and avoiding damaging hairstyles help regrowth.

Proscar (Finasteride) Inhibits 5α-Reductase Activity in the Ovaries and Testes of Lytechinus Variegatus Lamarck (Echinodermata: Echinoidea)

research Proscar@ (Finasteride) inhibits 5α-reductase activity in the ovaries and testes of Lytechinus variegatus Lamarck (Echinodermata: Echinoidea)

8 citations , October 1998 in “Comparative Biochemistry and Physiology Part C: Pharmacology, Toxicology and Endocrinology”

Proscar (finasteride) blocks 5α-reductase in sea urchin ovaries and testes, suggesting potential treatment for androgen-related conditions.

Synthesis and In Vitro Study of 17β-[N-Ureylene-N,N′-Disubstituted]-4-Methyl-4-Aza-5α-Androstan-3-Ones as Selective Inhibitors of Type I 5α-Reductase

research Synthesis and in vitro study of 17β-[N-ureylene-N,N′-disubstituted]-4-methyl-4-aza-5α-androstan-3-ones as selective inhibitors of type I 5α-reductase

5 citations , February 1997 in “Bioorganic & Medicinal Chemistry”

New compounds were made that effectively block a specific enzyme related to androgen conditions.

research Effect of the gonadotrophin releasing hormone analogue, goserelin, and oestradiol replacement on sebum excretion rates and hair size in mildly hirsute women

4 citations , January 1991 in “Journal of dermatological treatment”

Goserelin and oestradiol treatment slightly improved hairiness but did not significantly change sebum production or hair characteristics in mildly hirsute women.

research Balancing Hormones and Skin Health: A Focus on Oral Contraceptives in Dermatology

April 2025 in “La Prensa Medica”

Oral contraceptives help treat acne and hair issues by balancing hormones but need careful use due to possible side effects.

research Aspects of Cutaneous Androgen‐Dependent Syndromes

5 citations , September 1980 in “International Journal of Dermatology”

Understanding hormones is key to treating certain skin conditions.

research Non polycystic ovary syndrome–related endocrine disorders associated with hirsutism

39 citations , May 2011 in “European Journal of Clinical Investigation”

Hirsutism can be caused by various conditions besides PCOS, and it's important to treat the underlying issue and manage symptoms with medication and cosmetic approaches.

research Three cases of androgen‐dependent disease associated with myotonic dystrophy

8 citations , January 2003 in “JEADV. Journal of the European Academy of Dermatology and Venereology/Journal of the European Academy of Dermatology and Venereology”

Women with myotonic dystrophy might get diseases related to male hormones because their body tissues are extra sensitive to these hormones.

research Dermatology of androgen-related disorders

67 citations , July 2006 in “Clinics in Dermatology”

Androgens cause skin issues like acne and hair growth in women, often due to PCOS, and can be treated with medication and lifestyle changes.

research In Silico Screening of DrugBank Compounds as Potential Inhibitors for Human Steroid 5α-Reductase 2 for Androgen-Related Diseases

December 2023 in “Biointerface Research in Applied Chemistry”

Stiripentol shows promise as a potential treatment for androgen-related diseases but needs more testing.

research Hormonal Treatment for Skin Androgen-Related Disorders

January 2015

Hormonal treatments can help with hair loss, acne, and excess hair growth, but it takes 3-6 months to see results and patients should know the possible side effects.

research Hormone-related hair disorders - from clinical needs to new therapeutic perspectives

August 2006 in “Experimental dermatology”

New treatments targeting insulin, blood flow, and inflammation could improve hormone-related hair conditions with fewer side effects.

research The Function of 5α-reductase in Related Diseases

January 2011 in “Medical Recapitulate”

5α-reductase enzyme affects hormone levels, influencing conditions like acne and hair loss.

research Sex hormones and related compounds, including hormonal contraceptives

January 2014 in “Side effects of drugs annual”

Exposure to certain sex hormones can increase health risks, while some hormone therapies may offer benefits for specific conditions.

research No Evidence that 2D:4D is Related to the Number of CAG Repeats in the Androgen Receptor Gene

40 citations , January 2013 in “Frontiers in Endocrinology”

Finger length ratios are not linked to the number of specific gene repeats affecting testosterone sensitivity.

research ANTIANDROGEN AND HORMONAL TREATMENT OF ACNE

38 citations , October 1996 in “Dermatologic Clinics”

Certain hormone treatments can improve acne and related conditions in women.

research Antiandrogenic activity of Riboflavin 5′-phosphate (FMN) in 22Rv1 and LNCaP human prostate cancer cell lines

1 citations , January 2022 in “European Journal of Pharmacology”

Riboflavin 5′-phosphate (FMN) shows potential for treating androgen-related conditions but may be limited in treating prostate cancer.

research Attenzione divisa nei pazienti con cerebrolesione acquisita

January 2008 in “Journal of Medicinal Chemistry”

Finasteride may cause sexual and psychological side effects by affecting an enzyme related to epinephrine.

research Screening of synthetic and natural product databases: Identification of novel androgens and antiandrogens

14 citations , November 2014 in “European journal of medicinal chemistry”

Researchers found new potential treatments for conditions related to the androgen receptor, like male hormonal contraception, by testing thousands of compounds.

research Structure of human type II 5 alpha-reductase gene.

124 citations , September 1992 in “Endocrinology”

The human type II 5α-reductase gene, linked to certain male health conditions, has a specific structure and low similarity to other related genes.

research Effect of flutamide and two novel synthetic steroids on GABA, glutamine and some oxidative stress markers in rat brain and prostate

2 citations , January 2011 in “Andrologia”

Flutamide and a new synthetic steroid affected brain and prostate chemicals and showed potential for treating androgen-related conditions and epilepsy.

Synthesis and In Vitro Evaluation of 4-Substituted N-(1,1-Dimethylethyl)-3-Oxo-4-Androstene-17β-Carboxamides as 5α-Reductase Inhibitors and Antiandrogens

research Synthesis and in Vitro Evaluation of 4-Substituted N-(1,1-Dimethylethyl)-3-oxo-4-androstene-17.beta.-carboxamides as 5.alpha.-Reductase Inhibitors and Antiandrogens

12 citations , April 1995 in “Journal of Medicinal Chemistry”

The new compounds moderately block a specific enzyme and strongly counteract a male hormone, suggesting potential for treating certain male-related health conditions.

research ANTI‐ANDROGENS IN HIRSUTISM

1 citations , January 1979 in “International Journal of Dermatology”

Cyproterone acetate effectively treats hirsutism and related conditions.

research Dexamethasone, a Synthetic Glucocorticoid, Induces the Activity of Androgen Receptor in Human Dermal Papilla Cells

2 citations , January 2022 in “Skin Pharmacology and Physiology”

Dexamethasone increases the activity of androgen receptors in human skin cells, which may link it to certain types of hair loss.

research Androgen Receptor Polymorphisms (CAG Repeat Lengths) in Androgenetic Alopecia, Hirsutism, and Acne

186 citations , July 1998 in “Journal of Cutaneous Medicine and Surgery”

Shorter CAG repeats may cause hair and skin issues, while longer ones may link to acne.