53 citations
,
October 1984 in “Endocrine reviews” Excessive hair growth in women often has no known cause and is not linked to race or other hormonal symptoms.
42 citations
,
July 2015 in “Journal of The American Academy of Dermatology” The conclusion is that oral contraceptives and antiandrogens can treat hirsutism and acne in women with cutaneous hyperandrogenism, but more research is needed for effective treatments, especially for hair loss.
40 citations
,
March 2016 in “The Journal of Clinical Endocrinology & Metabolism” Young girls whose mothers have PCOS may have higher activity of a specific enzyme that could lead to developing PCOS later.
38 citations
,
June 2018 in “Archives of Toxicology” Different species and human skin models vary in their skin enzyme activities, with pig skin and some models closely matching human skin, useful for safety assessments and understanding the skin's protective roles.
27 citations
,
April 2013 in “Reviews in endocrine and metabolic disorders” The document concludes that using LC-MS/MS for measuring androgens is more accurate than older methods, but it needs careful validation and standardized references to be most effective.
27 citations
,
January 1984 in “Pharmacology & Therapeutics” Antiandrogens have important biological effects, but more research is needed to understand them fully and compare their effectiveness and side effects to other treatments.
22 citations
,
January 2002 in “Treatments in endocrinology” Birth control pills help treat skin and hair growth problems linked to high male hormone levels.
22 citations
,
April 2015 in “Current problems in dermatology” Human hair follicles have a unique metabolism that changes between growth stages and may contribute to baldness.
19 citations
,
November 2012 in “Journal of Dermatological Treatment” Isotretinoin improves severe acne without changing androgen or insulin levels but may increase body weight and triglycerides.
18 citations
,
March 2009 in “Medical Hypotheses” The document suggests that blocking sweat glands with antiperspirants might allow skin-generated hormones to be absorbed, possibly increasing breast and prostate cancer risk.
17 citations
,
August 2015 in “Journal of steroid biochemistry and molecular biology/The Journal of steroid biochemistry and molecular biology” The study found that urine metabolites M1b or M4 are the best indicators of ATD use in horses, with detection possible up to 77 hours in urine and 28 hours in blood.
16 citations
,
June 2008 in “Springer eBooks” Over 50% of women over 50 experience hair loss, with minoxidil being the only proven effective treatment.
14 citations
,
July 1987 in “Dermatologic Clinics” The document concludes that treating female hair loss should target reducing excess androgen and blocking its effects on hair follicles, with the best treatments being hormonal therapy, adrenal suppression, and topical minoxidil.
9 citations
,
January 1997 in “Gynecological Endocrinology” The document concludes that treating androgen excess needs patience, managing expectations is important, and many drugs used are not officially approved, suggesting cosmetic options for mild cases.
9 citations
,
October 1988 in “Clinics in Dermatology” Hair loss is caused by genetics and hormones, diagnosed through examination and biopsy, and treated with medications or surgery.
8 citations
,
June 2016 in “Clinical Chemistry” PSA levels could help detect illegal steroid use in female athletes but face challenges like cost and PCOS prevalence.
8 citations
,
May 1996 in “Endocrinology” Certain adrenal hormones can strongly stimulate oil gland growth in hamster skin, similar to male hormones.
8 citations
,
January 1996 in “Gynecological Endocrinology” Cyproterone acetate is the preferred treatment for women's hyperandrogenism when estrogen/progestogen use is safe.
7 citations
,
January 1992 in “Adolescent and pediatric gynecology” Early diagnosis and treatment of PCOS in teenagers can help prevent more severe adult PCOS.
December 2025 in “Scientific Reports” Gut microbiota and metabolic pathways may play a key role in PCOS development.
January 2020 in “Research Portal Denmark” A short male anogenital distance may indicate incomplete masculinization due to disrupted androgen action.
September 2014 in “Springer eBooks” Men and women experience skin aging differently due to changes in sex hormone levels with age.
June 2001 in “International Journal of Cosmetic Surgery and Aesthetic Dermatology” Finasteride improves hair growth in men with androgenetic alopecia.
24 citations
,
January 2013 in “Indian Journal of Dermatology, Venereology and Leprology” Hormonal treatment is effective for women with acne not helped by usual treatments, especially if they have hormonal imbalances.
15 citations
,
October 2010 in “Archives of Toxicology” A yeast-based test can detect the steroid methyltestosterone in urine longer than traditional methods.
78 citations
,
January 2000 in “Gynecological Endocrinology” Norgestimate is the most effective birth control progestin for reducing an enzyme linked to acne and excessive hair growth in women.
54 citations
,
July 2002 in “Clinical and Experimental Dermatology” DHT, a testosterone byproduct, causes male pattern baldness.
31 citations
,
January 2003 in “Dermatology” Steroidogenic isoenzymes may help improve treatments for common hair loss.
24 citations
,
December 2013 in “Sexual medicine reviews” Finasteride can cause sexual problems and depression in young men.
19 citations
,
April 2014 in “Hormones” Hormones and genetics play key roles in male and female baldness, which can affect mental health and may be linked to other health issues.