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GlossaryAngiogenic

process of forming new blood vessels from existing ones

Angiogenic refers to the process by which new blood vessels form from pre-existing ones. This is crucial for wound healing and the growth of tissues, including hair follicles. In the context of hair and alopecia, promoting angiogenesis can improve blood supply to the scalp, potentially aiding in hair growth and the treatment of hair loss conditions.

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research Human CD133 ⁺ Progenitor Cells Promote the Healing of Diabetic Ischemic Ulcers by Paracrine Stimulation of Angiogenesis and Activation of Wnt Signaling

245 citations , April 2009 in “Circulation Research”

CD133+ cells help heal diabetic ulcers by promoting blood vessel growth and activating Wnt signaling.

research Electrospun Nanofibers for Improved Angiogenesis: Promises for Tissue Engineering Applications

70 citations , August 2020 in “Nanomaterials”

Electrospun nanofibers show promise for enhancing blood vessel growth in tissue engineering but need further research to improve their effectiveness.

research Gene therapy to enhance angiogenesis in chronic wounds

36 citations , August 2022 in “Molecular Therapy — Nucleic Acids”

Gene therapy shows promise for healing chronic wounds but needs more research to overcome challenges.

research Differential expression of steroid 5α-reductase isozymes and association with disease severity and angiogenic genes predict their biological role in prostate cancer

30 citations , June 2010 in “Endocrine Related Cancer”

SRD5A1 is crucial in advanced prostate cancer, and blocking both SRD5A1 and SRD5A2 is more effective than targeting SRD5A2 alone.

research Angiogenin is expressed in human dermal papilla cells and stimulates hair growth

20 citations , October 2008 in “Archives of dermatological research”

Angiogenin helps hair grow by stimulating cell growth and blood vessel formation.

research Inhibiting the cytosolic function of CXXC5 accelerates diabetic wound healing by enhancing angiogenesis and skin repair

19 citations , August 2023 in “Experimental & Molecular Medicine”

Blocking CXXC5 speeds up diabetic wound healing by improving blood vessel growth and skin repair.

research 574 Three-dimensional culture of dermal papilla cells improves their in vitro angiogenic activity

November 2022 in “Journal of Investigative Dermatology”

Growing dermal papilla cells in 3D improves their ability to help form new blood vessels.

research Promotive effects of adenosine on human hair follicle growth and angiogenin expression

December 2016 in “Chinese Journal of Dermatology”

Adenosine boosts hair growth by increasing angiogenin levels.

Amlodipine Topical Cream: An Effective Hair Growth Promoter for an Alopecia Mouse Model via VEGF-Mediated Angiogenesis and Vasodilation

research Amlodipine topical cream: an effective hair growth promoter for an alopecia mouse model via VEGF-mediated angiogenesis and vasodilation

March 2026 in “Archives of Dermatological Research”

Amlodipine cream may help hair growth by improving blood flow.

research Dextran hydrogel scaffolds enhance angiogenic responses and promote complete skin regeneration during burn wound healing

527 citations , December 2011 in “Proceedings of the National Academy of Sciences”

Dextran hydrogels improve burn wound healing and skin regeneration.

research Control of hair growth and follicle size by VEGF-mediated angiogenesis

520 citations , February 2001 in “Journal of Clinical Investigation”

VEGF helps hair grow and determines follicle size by increasing blood vessel growth.

research Angiogenesis: a Dynamic Balance of Stimulators and Inhibitors

322 citations , January 1997 in “Thrombosis and Haemostasis”

Angiogenesis can be controlled by balancing stimulators like VPF/VEGF and inhibitors like TSP.

research The role of VEGF and thrombospondins in skin angiogenesis

164 citations , December 2000 in “Journal of Dermatological Science”

Targeting blood vessels may help treat skin diseases.

research Thymosin β4 promotes angiogenesis, wound healing, and hair follicle development

118 citations , December 2003 in “Mechanisms of Ageing and Development”

Thymosin β4 helps heal wounds, grow hair, and improve blood vessel formation.

research Targeted Overexpression of the Angiogenesis Inhibitor Thrombospondin-1 in the Epidermis of Transgenic Mice Prevents Ultraviolet-B-Induced Angiogenesis and Cutaneous Photo-Damage

93 citations , May 2002 in “Journal of Investigative Dermatology”

Overexpressing thrombospondin-1 in mice skin prevents UVB-induced skin damage.

Bio-Multifunctional Alginate/Chitosan/Fucoidan Sponges with Enhanced Angiogenesis and Hair Follicle Regeneration for Promoting Full-Thickness Wound Healing

research Bio-multifunctional alginate/chitosan/fucoidan sponges with enhanced angiogenesis and hair follicle regeneration for promoting full-thickness wound healing

83 citations , June 2020 in “Materials & Design”

Sponge helps heal wounds faster with less inflammation and better skin/hair growth.

research Nutraceuticals as anti-angiogenic agents: hopes and reality.

48 citations , March 2005 in “PubMed”

Some plant-based compounds might help control the growth of new blood vessels if further research confirms their effectiveness.

research Betacellulin Regulates Hair Follicle Development and Hair Cycle Induction and Enhances Angiogenesis in Wounded Skin

36 citations , October 2007 in “Journal of Investigative Dermatology”

Betacellulin helps blood vessel growth in wounds but delays hair growth.

Parathyroid Hormone-Related Protein and the PTH Receptor Regulate Angiogenesis of the Skin

research Parathyroid Hormone Hormone-Related Protein and the PTH Receptor Regulate Angiogenesis of the Skin

33 citations , May 2006 in “Journal of Investigative Dermatology”

PTHrP and its receptor can control blood vessel growth and hair development in mouse skin.

Thyroxine (T4) May Promote Re-Epithelialization and Angiogenesis in Wounded Human Skin Ex Vivo

research Thyroxine (T4) may promote re-epithelialisation and angiogenesis in wounded human skin ex vivo

27 citations , March 2019 in “PLoS ONE”

Thyroxine (T4) may help heal skin wounds by promoting new skin and blood vessel growth.

research 3D bioprinting of engineered exosomes secreted from M2-polarized macrophages through immunomodulatory biomaterial promotes in vivo wound healing and angiogenesis

22 citations , November 2024 in “Bioactive Materials”

3D bioprinting with special hydrogels helps heal wounds and grow new blood vessels.

research Influence of Recombinant Codon-Optimized Plasmid DNA Encoding VEGF and FGF2 on Co-Induction of Angiogenesis

15 citations , February 2021 in “Cells”

Transfected cells with VEGF and FGF2 genes improve skin wound healing by enhancing blood flow and regeneration.

research Conditioned media-integrated microneedles for hair regeneration through perifollicular angiogenesis

12 citations , August 2022 in “Journal of Controlled Release”

A new microneedle patch effectively promotes hair growth by increasing blood vessel formation around hair follicles.

research The Glypican-1/HGF/C-Met and Glypican-1/VEGF/VEGFR2 Ternary Complexes Regulate Hair Follicle Angiogenesis

10 citations , December 2021 in “Frontiers in cell and developmental biology”

Glypican-1 is important for blood vessel growth in hair follicles and could help treat hair loss.

research Angiogenic factor-driven improvement of refractory thin endometrium with autologous platelet-rich plasma intrauterine infusion in frozen embryo transfer cycles

9 citations , September 2024 in “Frontiers in Endocrinology”

Platelet-rich plasma infusion improved pregnancy outcomes for women with thin endometrium.

research The myeloid mineralocorticoid receptor regulates dermal angiogenesis and inflammation in glucocorticoid‐induced impaired wound healing

9 citations , July 2022 in “British Journal of Pharmacology”

Blocking the mineralocorticoid receptor improves wound healing by reducing inflammation and promoting blood vessel growth.

research The Angiogenic Potential of Mesenchymal Stem Cells from the Hair Follicle Outer Root Sheath

8 citations , February 2021 in “Journal of Clinical Medicine”

Hair follicle stem cells are promising for blood vessel formation and tissue repair.

research Promotion of Hair Growth by Traditionally Used Delphinium Staphisagria Seeds through Inducti on of Angiogenesis.

7 citations , January 2016 in “PubMed”

Delphinium staphisagria seeds can promote hair growth safely by increasing blood vessel formation.

research Identification of an osteopontin-derived peptide that binds neuropilin-1 and activates vascular repair responses and angiogenesis

5 citations , June 2024 in “Pharmacological Research”

FOL-026 peptide may help hair growth and cardiovascular health by improving blood flow and cell functions.

research Sonic hedgehog signaling promotes angiogenesis of endothelial progenitor cells to improve pressure ulcers healing by PI3K/AKT/eNOS signaling

5 citations , October 2023 in “Aging”

Sonic hedgehog signaling helps heal pressure ulcers by improving blood vessel growth.