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Five-alpha reductase inhibitors, like finasteride and dutasteride, can treat enlarged prostates, improve urination, reduce need for prostate surgery, and lower the risk of prostate cancer, but may increase the risk of higher grade prostate cancer. They can also treat male pattern baldness.

Ezetimibe effectively reduces prostate size in cases of benign prostatic hyperplasia.

CI-1033 causes skin lesions in rats, similar to humans, due to EGF receptor inhibition.

Urotensin II increases growth and VEGF production in rat skin cells by turning on the Wnt-β-catenin pathway.

5α-reductase inhibitors effectively treat enlarged prostate and hair loss but require careful use due to possible side effects.

Tofacitinib treatment for hair loss may worsen acne.

Oral Janus kinase inhibitors are effective for treating alopecia areata in adults.

JAK inhibitors for alopecia areata are linked to minor side effects like headache and acne, but not to an increased risk of serious adverse events.

Using 5-alpha reductase inhibitors may lower prostate cancer risk in people with androgenetic alopecia.