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November 2024 in “JAAD reviews.” Certain drugs can change hair color, either lightening or darkening it.
January 2013 in “วารสารเภสัชศาสตร์อีสาน (Isan Journal of Pharmaceutical Sciences, IJPS)” Safflower extract increases melanin production in certain skin cells without harming them.
June 2021 in “Asian Journal of Medical Sciences” Vitamin B12 deficiency can cause reversible skin darkening.
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April 2019 in “Molecules” Blackcurrant extract may help reduce hair loss by promoting stem cell activity in hair follicles.
September 2024 in “Vietnam Journal of Biotechnology” Astaxanthin may help protect hair cells from damage and prevent hair loss.
12 citations
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May 2023 in “Molecules” Polygoni Cuspidati Rhizoma et Radix contains compounds that inhibit certain enzymes.
March 2026 in “Preprints.org” Plerixafor may help treat pigmentation disorders by promoting skin repigmentation.
April 2024 in “JURNAL ILMU KEFARMASIAN INDONESIA” The mud mask with 22.5% kaolin and pomegranate peel extract worked best.
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October 2019 in “International Journal of Dermatology and Venereology” Zebrafish help understand genetic causes of skin pigment disorders like albinism.
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January 2025 in “Journal of Natural Products” Calancardin B may help reduce inflammation in immune cells.
November 2025 in “Zenodo (CERN European Organization for Nuclear Research)” Polyherbal hair dye creams are safer, effective, eco-friendly, and economical alternatives to synthetic dyes.
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January 2023 in “Plants” Plant bioactive compounds are important for health and can help prevent various diseases.
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April 2013 in “Science” Feather pigment patterns form through melanocyte arrangement and simple regulatory mechanisms.
January 1990 in “Springer eBooks” Some chemicals can permanently or temporarily remove color from skin and hair, which can be distressing and is not well-regulated in cosmetics.
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April 2016 in “Chinese Medicine” The research identified 12 antioxidant compounds in Polygonum multiflorum roots, suggesting these as quality markers for the plant's processed roots.
November 2025 in “Frontiers in Veterinary Science” A 1.0% tyrosine diet increases melanin in chicken feathers.
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May 2025 in “Antioxidants” Prunus africana bark has the highest antioxidant activity and phenolic content.
MITF and WNT3A are key in Dun Mongolian horse pigmentation.
January 2026 in “Frontiers in Bioscience-Landmark” Araliadiol protects skin cells from damage by boosting antioxidant defenses.
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May 2025 in “Chemical and Biological Technologies in Agriculture” Humic acids enhance plant growth by improving root development and photobiology.
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March 2000 in “Journal of Biological Chemistry” Agouti and AGRP affect pigmentation and obesity, with implications for metabolic disorders.
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September 2015 in “PharmaNutrition” Astaxanthin is a safe antioxidant that may improve heart, skin, eye health, and physical performance, and help manage chronic diseases.
July 2024 in “Journal of Investigative Dermatology” Topical sulforaphane reduces pigmentation and wrinkles from sun damage.
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February 2022 in “International Journal of Health and Pharmaceutical (IJHP)” Combining cantigi and henna leaf extracts boosts antioxidant activity.
Hibiscus rosa-sinensis can naturally help heal skin inflammation.
February 2024 in “Planta” TRM21 helps control flavonoid production and root hair growth in Arabidopsis thaliana.
January 2017 in “Clinical approaches and procedures in cosmetic dermatology” Anti-glycation treatments might slow skin aging, but more research is needed.
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January 2025 in “Pharmaceutics” The gel is a safe and effective treatment for hyperpigmentation.
Retinoids can help treat skin pigmentation disorders by affecting melanin production.