January 2026 in “Cronfa (Swansea University)” Finasteride and dutasteride may increase the risk of depression and suicidality, so patients should be monitored closely.
134 citations
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August 2012 in “The Journal of Clinical Psychiatry” Former finasteride users with persistent sexual side effects have higher rates of depression and suicidal thoughts.
4 citations
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July 2021 in “Journal of Dermatological Treatment” Finasteride helps hair growth but may cause sexual side effects and depression.
2 citations
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March 2016 in “Journal of Mind and Medical Sciences” Finasteride, used for treating hair loss, can cause mental, physical, and sexual side effects, some of which may persist even after stopping the drug, and it can also cause mild to moderate oral issues.
November 2020 in “Reactions Weekly” Finasteride use linked to increased suicidality in patients under 45.
May 2026 in “Reactions Weekly” Finasteride and dutasteride may increase the risk of suicide and sexual dysfunction.
June 2017 in “Reactions Weekly” Finasteride (Propecia) may cause depression and suicidal thoughts; stop use and inform a healthcare professional if symptoms develop.
April 2008 in “Sexologies” Knowing about potential side effects can make them more likely to happen.
November 2020 in “Reactions Weekly” Finasteride can cause lasting erectile dysfunction, low libido, and depression in some patients.
August 2025 in “medRxiv (Cold Spring Harbor Laboratory)” 5-alpha reductase inhibitors may increase depression risk by 31%, but results vary based on comparison groups.
September 2020 in “Journal of Education, Health and Sport” Most patients on isotretinoin for acne experience mild, dose-related side effects, but the connection to depression or bowel disease is uncertain.
August 2024 in “medRxiv (Cold Spring Harbor Laboratory)” Finasteride has various adverse effects, including sexual dysfunction and mental health issues, which vary by age and gender.
January 2013 in “Psychiatry and clinical neurosciences” Physical symptoms in depression can reveal underlying medical conditions.
November 2003 in “Journal of Dermatology” Finasteride's link to depression is questionable due to study flaws and potential bias.
December 2022 in “JAMA network open” 5α-Reductase inhibitors may increase depression risk but not dementia or suicide.
2 citations
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November 2021 in “Journal of Clinical Psychopharmacology” Finasteride may affect mood and increase suicidal risk.
May 2017 in “Psychiatric news” BPH medications may increase the risk of self-harm and depression, especially in the first 18 months.
January 1983 in “Side effects of drugs annual” Beta-blockers and anti-anginal medications have various side effects and interactions that require careful monitoring and individualized treatment.
May 2024 in “Reactions weekly”
39 citations
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January 2012 in “Indian Dermatology Online Journal” Finasteride may cause sexual side effects like erectile dysfunction, but they are reversible and affect less than 2% of men.
1 citations
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August 2017 in “The Journal of urology/The journal of urology” 5α-reductase inhibitors may increase the risk of depression and suicidal thoughts.
April 2017 in “Reactions Weekly” Man experienced sexual dysfunction, depression, breast growth, and skin discoloration after taking finasteride for hair loss.
9 citations
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January 2009 in “PubMed” Finasteride treatment can decrease certain steroids and increase others, possibly leading to depression symptoms in some cases.
January 2008 in “Journal of Medicinal Chemistry” Finasteride may cause sexual and psychological side effects by affecting an enzyme related to epinephrine.
11 citations
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January 1980 in “PubMed” Oral contraceptives can cause nausea, headaches, mood changes, and other side effects, especially early on.
March 2021 in “Clin-Alert” The FDA warned about safety issues with remdesivir and tofacitinib, finasteride is linked to suicidality, potent topical corticosteroids increase osteoporosis risk, henna can cause hemolysis in G6PD deficiency, chemotherapeutic agents can cause adverse reactions, drug interactions are common in cancer patients, ketamine can reduce at-risk drinking, high dose of anticholinergics increases dementia risk in Parkinson's patients, and prenatal exposure to second-generation antipsychotics increases pregnancy complications.
July 2025 in “Reactions Weekly” Finasteride may cause depression and affect brain and gut health in male rats.
December 2025 in “The Journal of Clinical Psychiatry” Finasteride is not proven to cause depression or suicide, and careful patient monitoring is advised.
January 2013 in “Yearbook of Urology” Former finasteride users showed higher rates of depression and suicidal thoughts compared to those who never used it.