research Oral Retinoids in Dermatology
Oral retinoids are effective for severe skin conditions but require careful use due to side effects.
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research Endogenous retinoids in the hair follicle and sebaceous gland
Maintaining the right amount of retinoic acid is crucial for healthy hair and skin.
research A Novel Approach for Skin Regeneration by a Potent Bioactive Placental-Loaded Microneedle Patch: Comparative Study of Deer, Goat, and Porcine Placentas
Goat placenta in microneedle patches is effective and safe for skin regeneration.
research Androgen receptor transactivity is potentiated by TGF-β1 through Smad3 but checked by its coactivator Hic-5/ARA55 in balding dermal papilla cells
TGF-β1 increases androgen receptor activity in hair loss, but Hic-5/ARA55 can counter this effect.
research Regional difference in sebum production by androgen susceptibility in human facial skin
The T-zone on the face has more androgen receptors and produces more oil than the U-zone.
research A Comparative Review of Alternative Fucoidan Extraction Techniques from Seaweed
All extraction methods can produce similar quality fucoidan, but a holistic approach is needed for method selection.
research The clock gene brain and muscle Arnt-like protein-1 (BMAL1) is involved in hair growth
A gene called BMAL1 plays a role in controlling hair growth.
research Interaction between estrogens and androgen receptor genes microsatellites, prostate-specific antigen and androgen receptor expressions in breast cancer
Certain gene patterns in breast cancer are linked to how active hormone receptors are and could affect patient survival.
research Polymorphic CAG Repeat Numbers in the Androgen Receptor Gene of Female Pattern Hair Loss in a Han Chinese Population
No significant link between CAG repeat numbers and female pattern hair loss in Han Chinese population.
research Combined oral contraceptives promote androgen receptor and oestrogen receptor alpha upregulation in the female prostate (Skene’s paraurethral glands) of adult gerbils (Meriones unguiculatus)
Birth control pills increase certain receptor activities in female gerbil prostate glands and can lead to prostate changes.
research Is the “Comb Over” Dying? A Mouse Model for Male Pattern Baldness (Androgenic Alopecia)
The mouse model suggests male pattern baldness may be due to an enzyme increasing DHT and higher androgen receptor levels in hair follicles.
research A KRT71 Loss-of-Function Variant Results in Inner Root Sheath Dysplasia and Recessive Congenital Hypotrichosis of Hereford Cattle
A specific genetic change in the KRT71 gene causes a hair loss condition in Hereford cattle.
research Development and Validation of Androgen-induced Hair Loss and Anagen Induction Mouse Models for Pharmacological Evaluation of Anti-Androgenic Agents
The mouse models are effective for testing new hair loss treatments.
research Nanoliposomal Co-Delivery of AR-PROTAC and NFKBIZ siRNA for Synergistic Therapy of Androgenetic Alopecia
A new treatment using nanoliposomes can improve hair regrowth in androgenetic alopecia.
research Comparative Effect of Conventional and Non-Conventional Over-the-Counter Treatments for Male Androgenetic Alopecia: A Network Meta-Analysis Study
Topical minoxidil 5% is the most effective over-the-counter treatment for male hair loss.
research Ellagic acid inhibits dihydrotestosterone-induced ferroptosis and promotes hair regeneration by activating the Wnt/β-catenin signaling pathway
Ellagic acid may help regrow hair and prevent hair loss by activating a specific cell growth pathway.
research The role of mutations on gene AR, in androgenetic alopecia syndrome
Mutations in the AR gene cause hair thinning and loss.
research A Review of Keratin-Based Biomaterials for Biomedical Applications
Keratin from hair and wool is used in medical materials for healing and drug delivery.
research A Mouse Model for the Basal Transcription/DNA Repair Syndrome Trichothiodystrophy
Researchers created a mouse with the same mutation as humans with trichothiodystrophy, showing similar symptoms and confirming the condition is due to defects in DNA repair and gene activity.
research Combined effect of high-dose vitamin A, vitamin E supplementation, and zinc on adult patients with diabetes: A randomized trial
High-dose vitamin A and E with zinc improved blood sugar control and insulin function in diabetics, but may cause hair loss.
research A novel chitosan-peptide system for cartilage tissue engineering with adipose-derived stromal cells
The chitosan-peptide system helps cartilage regeneration using fat-derived cells.
research Effect of nutrient antioxidants on oxidative stress indicators in patients with alopecia areata
Antioxidants can help improve hair growth in people with alopecia areata.
research Inhibition of Inflammatory Gene Expression in Keratinocytes Using a Composition Containing Carnitine, Thioctic Acid and Saw Palmetto Extract
The composition with carnitine, thioctic acid, and saw palmetto extract may effectively reduce inflammation in hair follicle cells.
research Alopecia - the search for novel agents continues
Many potential alopecia treatments need more testing to confirm they promote acceptable hair growth with minimal side effects.
research 5α-reductase activity in the prostate
Blocking the enzyme 5α-reductase can shrink the prostate and help treat enlarged prostate issues.
research Sebocytes are the Key Regulators of Androgen Homeostasis in Human Skin
Sebocytes play a key role in controlling androgen levels in human skin.
research A Hot New Twist to Hair Biology
Capsaicin, found in chili peppers, can slow down hair growth by affecting skin cells and hair follicles.
research Characterization and Management of Hedgehog Pathway Inhibitor-Related Adverse Events in Patients With Advanced Basal Cell Carcinoma
Understanding and managing side effects of hedgehog pathway inhibitors can improve treatment for advanced basal cell carcinoma.
research Adverse effects of 5α-reductase inhibitors: What do we know, don’t know, and need to know?
5α-reductase inhibitors may cause persistent sexual dysfunction and depression, needing more research on long-term effects.
research 9 Role of 5α-reductase in health and disease
5α-reductase is essential for male sexual development and its inhibitors have potential in treating various conditions related to hormone action.