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research ISID1343 - Efficacy of asymmetric siRNA targeting androgen receptor for the treatment of androgenetic alopecia

May 2023

The conclusion is that a treatment called cp-asiAR can reduce hair loss and promote hair growth, making it a potential new therapy for androgenetic alopecia.

Protac Degraders of Androgen Receptor-Integrated Dissolving Microneedles for Androgenetic Alopecia and Recrudescence Treatment via Single Topical Administration

research PROTAC Degraders of Androgen Receptor‐Integrated Dissolving Microneedles for Androgenetic Alopecia and Recrudescence Treatment via Single Topical Administration

December 2022 in “Small methods”

A new hair loss treatment using dissolving microneedles was found to speed up hair growth and was more effective than daily use of common hair growth drugs.

research Bioinspired multifunctional injectable hydrogel for hemostasis and infected wound management

16 citations , January 2023 in “Acta Biomaterialia”

The hydrogel quickly stops bleeding and helps heal infected wounds.

research Inorganic Nanozymes: Prospects for Disease Treatments and Detection Applications

23 citations , November 2021 in “Frontiers in Chemistry”

Nanozymes could improve disease treatment and detection.

research Genetically engineered biomimetic ATP-responsive nanozyme for the treatment of cardiac fibrosis

2 citations , January 2025 in “Journal of Nanobiotechnology”

A new engineered treatment shows promise in curing heart fibrosis.

research Suspected upadacitinib-associated drug hypersensitivity mimicking disease exacerbation in ulcerative colitis

April 2026 in “Clinical Journal of Gastroenterology”

Upadacitinib can cause hypersensitivity that worsens ulcerative colitis symptoms.

research The Association of Gene Expression and Single Nucleotide Polymorphism (rs 6152 SNP) in Androgen Receptor Gene with Recurrent Spontaneous Abortion (RSA) in Iraqi Women

March 2021 in “Medico-Legal Update”

The androgen receptor gene doesn't affect women with recurrent spontaneous abortions, but having a mutant genotype might protect against it.

Double-Stranded RNA Induces Inflammation via the NF-κB Pathway and Inflammasome Activation in the Outer Root Sheath Cells of Hair Follicles

research Double-stranded RNA induces inflammation via the NF-κB pathway and inflammasome activation in the outer root sheath cells of hair follicles

22 citations , March 2017 in “Scientific reports”

Double-stranded RNA causes inflammation in hair follicle cells, which may help understand and treat alopecia areata.

research 199 Impairment of notch 1 signaling is a common defect in lesions from patients with hidradenitis suppurativa

2 citations , September 2017 in “Journal of Investigative Dermatology”

Notch1 signaling is impaired in hidradenitis suppurativa, affecting skin and hair cells.

research Fatal autoimmunity results from the conditional deletion of Snai2 and Snai3

8 citations , February 2015 in “Cellular immunology”

Deleting Snai2 and Snai3 causes fatal autoimmunity.

research 527 PTEN is a master driver of healing inhibition in venous leg ulcers by targeting immune response, angiogenesis and lymphangiogenesis

November 2024 in “Journal of Investigative Dermatology”

Targeting PTEN can improve healing in venous leg ulcers.

research Gsdma3 Mutation Causes Bulge Stem Cell Depletion and Alopecia Mediated by Skin Inflammation

54 citations , December 2011 in “American Journal Of Pathology”

A Gsdma3 mutation causes hair loss due to stem cell damage from skin inflammation.

research Comparative GC-MS Based In vitro Assays of 5α-Reductase Activity Using Rat Liver S9 Fraction

8 citations , March 2012 in “Mass spectrometry letters”

The S9 fraction with GC-IDMS is effective for measuring 5α-reductase activity.

Angelica Gigas Nakai (Korean Dang-Gui) Root Alcoholic Extracts in Health Promotion and Disease Therapy: Active Phytochemicals and In Vivo Molecular Targets

research Angelica gigas Nakai (Korean Dang-gui) Root Alcoholic Extracts in Health Promotion and Disease Therapy – active Phytochemicals and In Vivo Molecular Targets

2 citations , January 2025 in “Pharmaceutical Research”

Angelica gigas Nakai root extracts may help with cancer, pain, memory loss, and metabolic issues.

Comprehensive Analysis of LncRNA AC010789.1 Delays Androgenic Alopecia Progression by Targeting MicroRNA-21 and the Wnt/β-Catenin Signaling Pathway in Hair Follicle Stem Cells

research Comprehensive Analysis of LncRNA AC010789.1 Delays Androgenic Alopecia Progression by Targeting MicroRNA-21 and the Wnt/β-Catenin Signaling Pathway in Hair Follicle Stem Cells

3 citations , February 2022 in “Frontiers in Genetics”

The LncRNA AC010789.1 slows down hair loss by promoting hair follicle growth and interacting with miR-21 and the Wnt/β-catenin pathway.

research Spermine Lipid Assembled Nanoparticles for siRNA Delivery and Androgenetic Alopecia Therapy

April 2026 in “ACS Applied Materials & Interfaces”

Sper-12 nanoparticles may help treat hair loss by delivering siRNA to target androgen receptors.

Enzymatic Synthesis of Alpha-Glucosyl-Baicalin Through Transglucosylation via Cyclodextrin Glucanotransferase in Water

research Enzymatic Synthesis of α-Glucosyl-Baicalin through Transglucosylation via Cyclodextrin Glucanotransferase in Water

May 2023 in “Molecules”

Enzymatic synthesis improved the water solubility of the flavonoid baicalin, which may help treat hair loss conditions.

research The effect of proteolytic enzymes on hair follicles of transgenic mice expressing the lac Z‐protein in cells of the bulge region

5 citations , July 1999 in “JEADV. Journal of the European Academy of Dermatology and Venereology/Journal of the European Academy of Dermatology and Venereology”

Proteolytic enzymes damage hair follicles by detaching stem cells.

research Differential proteomics of lesional vs. non-lesional biopsies revealed non-immune mechanisms of alopecia areata

19 citations , January 2018 in “Scientific Reports”

Non-immune factors play a significant role in alopecia areata.

No Genetic Support for a Contribution of Prostaglandins to the Etiology of Androgenetic Alopecia

research No genetic support for a contribution of prostaglandins to the aetiology of androgenetic alopecia

7 citations , March 2013 in “British Journal of Dermatology”

No genetic link between prostaglandins and hair loss found.

research Antimicrobial and Antibiofilm Activities of Abietic Acid against Skin-Associated Opportunistic Microorganisms

February 2026 in “Journal of Microbiology and Biotechnology”

Abietic acid from pine rosin can effectively fight and reduce harmful skin microbes.

research Increased plasma renin by vasodilators promotes the progression of abdominal aortic aneurysm

1 citations , June 2023 in “Frontiers in Pharmacology”

Vasodilators may worsen abdominal aortic aneurysm.

Bioinspired Engineering of ADSC Nanovesicles in Thermosensitive Hydrogel to Enhance Autophagy of Dermal Papilla Cells for Androgenetic Alopecia Treatment

research Bioinspired engineering ADSC nanovesicles thermosensitive hydrogel enhance autophagy of dermal papilla cells for androgenetic alopecia treatment

March 2024 in “Bioactive Materials”

New treatment using engineered nanovesicles in hydrogel improves hair growth by repairing hair follicle cells in a mouse model of hair loss.

OsUEV1B, a Ubc Enzyme Variant Protein, Is Required for Phosphate Homeostasis in Rice

research OsUEV1B, an Ubc enzyme variant protein, is required for phosphate homeostasis in rice

4 citations , February 2021 in “Plant journal”

OsUEV1B protein is essential for controlling phosphate levels in rice.

research Simultaneous Typing of Erythrocyte Acid Phosphatase, Adenylate Kinase and Adenosine Deaminase in Human Hair Root Sheaths

1 citations , September 1986 in “Journal of the Forensic Science Society”

Hair root sheaths can be used to accurately analyze genetic markers.