research Modeling and Simulation of X-Rays Radiotherapy
Microbeam Radiation Therapy is effective, but using a linear accelerator reduces its benefits.
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780-810 / 1000+ resultsresearch Effect of thioredoxin reductase 1 on glucocorticoid receptor activity in human outer root sheath cells
Thioredoxin reductase 1 does not affect glucocorticoid receptor activity in hair follicle cells.
research A Full Factorial Design to Optimize Aminexil Nano Lipid Formulation to Improve Skin Permeation and Efficacy Against Alopecia
research Emerging and traditional 5-α reductase inhibitors and androgen receptor antagonists for male androgenetic alopecia
New treatments for male hair loss are being explored to improve effectiveness and reduce side effects.
research Building a Better Scar: Re-engineering Extracellular Matrix Structure in Dermal Scars
αCT1 improves scar appearance by changing early collagen structure.
research A Natural Product Molecule of Artocarpus Heterophyllus Reverses Inflammation Due to the Effect of Acute Exposure of Prostate Tissue to Testosterone Enanthate in Wistar Rats
Artocarpus heterophyllus seed extract may help treat prostate inflammation without side effects.
research Aconiti Lateralis Preparata Radix Activates the Proliferation of Mouse Bone Marrow Mesenchymal Stem Cells and Induces Osteogenic Lineage Differentiation through the Bone Morphogenetic Protein-2/Smad-Dependent Runx2 Pathway
Aconiti Lateralis Preparata Radix helps mouse stem cells grow and turn into bone cells faster than usual methods.
research EFFICACY OF INTRALESIONAL BOTULINUM TOXIN INJECTION IN THE TREATMENT OF PATCHY ALOPECIA AREATA (AA)
Both treatments help hair regrowth, but Botulinum Toxin-A has fewer side effects.
research Gut instinct: Using tofacitinib to treat alopecia areata in the context of comorbid inflammatory bowel disease
This study explored the use of the Janus kinase (JAK) inhibitor tofacitinib in treating patients with both alopecia areata (AA) and inflammatory bowel disease (IBD), specifically ulcerative colitis (UC) and Crohn disease. A retrospective chart review was conducted on 9 patients aged 18 and older, revealing that 6 out of 7 patients with active IBD achieved remission of both IBD and AA with tofacitinib. The study highlighted the potential overlap in the pathobiology of AA and IBD and suggested that JAK inhibitors could be a viable treatment option for patients with these comorbid autoimmune conditions. However, the study was limited by its small sample size and the fact that all patients were from a single clinic.
research Baricitinib Attenuates IFN-γ and Polyinosinic:polycytidylic Acid‒Induced Mitochondrial Damage and Inflammasome Activation in Human Keratinocytes
The study explored the impact of baricitinib, a JAK inhibitor, on mitochondrial damage and inflammasome activation in human keratinocytes, particularly in the context of alopecia areata (AA). It was found that baricitinib effectively inhibited the JAK/STAT pathway, reduced mitochondrial DNA damage, and decreased reactive oxygen species (ROS) levels, which prevented the activation of the NLRP3 inflammasome and led to reduced IL-1β secretion. This indicated that baricitinib could mitigate inflammatory responses in AA. The research underscored the potential of JAK inhibitors in addressing mitochondrial and oxidative stress-related mechanisms in AA pathogenesis, suggesting their benefit in managing keratinocyte inflammation.
research Methotrexate injection site reactions: Case report and literature review
Methotrexate injection site reactions are rare but can be managed by changing injection sites and using topical treatments.
research Un nuevo anovulador antiandrogénico
El acetato de ciproterona trata problemas androgénicos como hirsutismo, acné, seborrea y alopecia con diferentes dosis y combinaciones.
research Long-term Prophylaxis with Androgens in the management of Hereditary Angioedema (HAE) in emerging countries
Long-term use of androgens can help manage Hereditary Angioedema (HAE) but may cause serious side effects, so alternative treatments with fewer side effects are being considered.
research Moving Beyond Boundaries: Utilization of Longitudinal Exposure–Response Model for Bounded Outcome Score to Inform Decision Making in the Accelerated Drug Development Paradigm
A 50 mg daily dose of ritlecitinib is effective for alopecia areata, with temporary treatment breaks up to 6 weeks not affecting results.
research A10.09 Safety data of four treatment regimens in early rheumatoid arthritis patients
All four treatments for early rheumatoid arthritis had similar and mostly mild side effects.
research Systematic review and indirect treatment comparisons of ritlecitinib against baricitinib in alopecia areata
Ritlecitinib and baricitinib are similarly effective for hair regrowth in severe alopecia areata.
research Aceclofenac-induced erythema annulare centrifugum
A woman got a skin rash from taking aceclofenac, which went away after she stopped the drug.
research Atypical fibroxanthoma of the scalp following hair transplantation in a 35-year-old male
A man developed a rare cancer on his scalp after a hair transplant possibly due to sun damage, laser effects, and inflammation.
research Signal Mining for Non-Bleeding Adverse Event in Novel Oral Anticoagulants: A Pharmacovigilance Study Based on the FAERS Database
Different oral anticoagulants cause various non-bleeding side effects, so careful monitoring is needed.
research 308 nm–Excimer light together with topical betamethasone valerate in treating alopecia areata
Using Excimer light with topical steroids is the most effective treatment for alopecia areata.
research AB0389 Methotrexate Treatment for Rheumatoid Arthritis in Poland: Retrospective Analysis of Patients in Routine Clinical Practice
Methotrexate is effective for treating rheumatoid arthritis but requires regular monitoring.
research A Case of Unexpected Successful Treatment of Alopecia Areata With Tralokinumab in a Patient With Atopic Dermatitis
Tralokinumab successfully treated alopecia areata in a patient with atopic dermatitis.
research Mechanistic study of Erianin in alopecia areata
Erianin may effectively treat alopecia areata by targeting the immune system.
research JAK Inhibitors in African American Patients With Alopecia Areata: A Case Series
JAK inhibitors effectively reduce alopecia areata symptoms in Black patients.
research 63418 JAK3/TEC kinase pathways are active in alopecia areata lesions, and their inhibition with Ritlecitinib prevents αCD3/αCD28+IL-2 induced immune privilege collapse in healthy hair follicles ex vivo
Ritlecitinib may help treat alopecia areata by protecting hair follicles.
research Les cançons de l'escarni
Agaricus bisporus β-Glucan particles could effectively treat cervical cancer and offer antimicrobial and antioxidant benefits.
research Phase I Study of the Hedgehog Pathway Inhibitor IPI-926 in Adult Patients with Solid Tumors
The drug IPI-926 is safe at 160 mg daily and may help treat certain tumors, especially basal cell carcinoma.
research Real-life effectiveness and safety of baricitinib in 17 Japanese patients with alopecia areata: a 60-week single center study
Baricitinib is effective for treating severe alopecia areata in Japanese patients, but long-term safety needs more study.
research Differential activity of 2-methylene-19-nor vitamin D analogs on growth factor gene expression in rhino mouse skin and comparison to all-trans retinoic acid
Some vitamin D analogs can thicken skin and reduce pore size like a common acne treatment, with one analog also affecting skin growth factors.
research Hair loss disorders (alopecias)
Ritlecitinib is a new treatment for severe hair loss in people 12 and older.