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research Regulation of Tmem30b-mediated apical membrane homeostasis in auditory outer hair cells is critical for hearing

April 2026 in “Proceedings of the National Academy of Sciences”

The study identifies Tmem30b as a crucial regulator in outer hair cells (OHCs) for hearing, highlighting its role in maintaining the structure of hair bundles in the cochlea. Tmem30b, a phospholipid-flippase chaperone, initially localizes to the nuclear membrane and later stabilizes in the stereocilia and cuticular plate. Tmem30b −/− mice show early-onset hearing loss due to disorganized OHC stereocilia, starting at P7. Tmem30b partners with Atp8b1 to regulate phospholipid asymmetry, and disruption of this complex destabilizes OHC bundles. AAV-mediated delivery of Tmem30b to hair cells corrects stereocilia defects in Tmem30b −/− and Atp8b1 −/− mice, and overexpression of Tmem30b protects against noise-induced and aminoglycoside-induced hearing loss. The findings suggest Tmem30b–Atp8b1–mediated lipid regulation as a potential therapeutic target for hearing loss.

research Defining BMP functions in the hair follicle by conditional ablation of BMP receptor IA

250 citations , November 2003 in “The Journal of Cell Biology”

BMP receptor IA is essential for proper hair cell differentiation in mice.

research Class IIa HDAC4 and HDAC7 cooperatively regulate gene transcription in Th17 cell differentiation

16 citations , April 2024 in “Proceedings of the National Academy of Sciences”

HDAC4 and HDAC7 are crucial for Th17 cell development and could be targeted to treat inflammatory diseases.

research Direct evidence supporting the existence of a helical dislocation in protofilament packing in the intermediate filaments of oxidized trichocyte keratin

3 citations , September 2018 in “Journal of Structural Biology”

Oxidized trichocyte keratin has a helical dislocation in its structure.

AGD1, A Class 1 ARF-GAP, Acts in Common Signaling Pathways with Phosphoinositide Metabolism and the Actin Cytoskeleton in Controlling Arabidopsis Root Hair Polarity

research AGD1, a class 1 ARF‐GAP, acts in common signaling pathways with phosphoinositide metabolism and the actin cytoskeleton in controlling Arabidopsis root hair polarity

56 citations , December 2011 in “The Plant Journal”

AGD1 is important for root hair development in Arabidopsis, working with phosphoinositide signaling and the actin cytoskeleton.

research HOMEOBOX PROTEIN 24 mediates the conversion of indole‐3‐butyric acid to indole‐3‐acetic acid to promote root hair elongation

21 citations , September 2021 in “New Phytologist”

HB24 helps convert IBA to IAA, promoting root hair growth.

research Faculty Opinions recommendation of The Venus flytrap trigger hair-specific potassium channel KDM1 can reestablish the K+ gradient required for hapto-electric signaling.

December 2020 in “Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature”

The KDM1 gene helps Venus flytraps close by managing potassium ions.

research Physical and Functional Interaction between the Vitamin D Receptor and Hairless Corepressor, Two Proteins Required for Hair Cycling

215 citations , September 2003 in “Journal of Biological Chemistry”

Vitamin D receptor and hairless protein are essential for hair growth.

research Hairless Suppresses Vitamin D Receptor Transactivation in Human Keratinocytes

78 citations , November 2005 in “Endocrinology”

Hairless protein can block vitamin D activation in skin cells.

research WIF1 Is Expressed by Stem Cells of the Human Interfollicular Epidermis and Acts to Suppress Keratinocyte Proliferation

18 citations , January 2013 in “Journal of Investigative Dermatology”

WIF1 helps keep skin stem cells inactive to prevent excessive cell growth.

research Androgen receptor inhibits the hair follicle induction potential of dermal papilla cells by binding with Tcf4 at the A574 binding site

4 citations , May 2022 in “Genes & Diseases”

research Data from Activator Protein-1 Activity Regulates Epithelial Tumor Cell Identity

March 2023

Inhibiting AP-1 changes skin tumor types and affects tumor cell identity.

research Data from Activator Protein-1 Activity Regulates Epithelial Tumor Cell Identity

March 2023

Inhibiting AP-1 changes skin tumor types and affects tumor cell identity.

research GATA3 inhibits proliferation and induces expression of both early and late differentiation markers in keratinocytes of the human epidermis

24 citations , December 2013 in “Archives of Dermatological Research”

research Myodegeneration in EDA-A2 Transgenic Mice Is Prevented by XEDAR Deficiency

75 citations , January 2004 in “Molecular and Cellular Biology”

XEDAR deficiency prevents muscle degeneration in EDA-A2 transgenic mice.

research A novel calmodulin‐interacting Domain of Unknown Function 506 protein represses root hair elongation in Arabidopsis

14 citations , March 2022 in “Plant Cell & Environment”

The protein AtRXR3 limits root hair growth in Arabidopsis, affecting phosphorus uptake.

Androgen Receptor Transactivity Is Potentiated by TGF-β1 Through Smad3 but Checked by Its Coactivator Hic-5/ARA55 in Balding Dermal Papilla Cells

research Androgen receptor transactivity is potentiated by TGF-β1 through Smad3 but checked by its coactivator Hic-5/ARA55 in balding dermal papilla cells

19 citations , September 2011 in “Journal of Dermatological Science”

TGF-β1 increases androgen receptor activity in hair loss, but Hic-5/ARA55 can counter this effect.

research In Vitro Assembly and Structure of Trichocyte Keratin Intermediate Filaments

91 citations , December 2000 in “The journal of cell biology/The Journal of cell biology”

Scientists successfully created mouse hair proteins in the lab, which are stable and similar to natural hair.

research Intercellular Adhesion Molecule-1 and Hair Follicle Regression

29 citations , April 2000 in “Journal of histochemistry and cytochemistry/The journal of histochemistry and cytochemistry”

ICAM-1 helps regulate hair growth cycles and skin remodeling.

research Interactions of the Vitamin D Receptor with the Corepressor Hairless

42 citations , July 2007 in “Journal of Biological Chemistry”

Most Hairless gene mutations reduce its ability to work with the Vitamin D Receptor, which might explain a certain type of hair loss.

research L-Ornithine ketoacid-transaminase assay in hair roots of homozygotes and heterozygotes for gyrate atrophy

8 citations , June 1981 in “Clinica Chimica Acta”

research Monilethrix: Mutational Hotspot in the Helix Termination Motif of the Human Hair Basic Keratin 6

32 citations , January 2000 in “Human Heredity”

Monilethrix severity varies and may be influenced by other genetic or environmental factors.

research 320 Desmoglein 3-mediated mechanical transadhesion controls epithelial stem cell quiescence

October 2021 in “The journal of investigative dermatology/Journal of investigative dermatology”

Desmoglein 3 is important for keeping hair follicle stem cells inactive and maintaining their special properties.

research Two Different Mutations in the Same Codon of a Type II Hair Keratin (hHb6) in Patients with Monilethrix

20 citations , December 1999 in “Journal of Investigative Dermatology”

Mutations in the hHb6 gene cause the hair disorder monilethrix.

Loss-Of-Function Mutations of an Inhibitory Upstream ORF in the Human Hairless Transcript Cause Marie Unna Hereditary Hypotrichosis

research Loss-of-function mutations of an inhibitory upstream ORF in the human hairless transcript cause Marie Unna hereditary hypotrichosis

181 citations , January 2009 in “Nature Genetics”

Certain mutations in a hair growth-related gene cause a type of genetic hair loss.

research A missense mutation in the type II hair keratin hHb3 is associated with monilethrix

79 citations , March 2005 in “Journal of Medical Genetics”

A mutation in the hHb3 gene is linked to the hair disorder monilethrix.

research Endothelial NMMHC IIA dissociation from PAR1 activates the CREB3/ARF4 signaling in thrombin-mediated intracerebral hemorrhage

4 citations , November 2024 in “Journal of Advanced Research”

Targeting NMMHC IIA may help treat blood-brain barrier damage.

Ligand-Independent Regulation of the Hairless Promoter by Vitamin D Receptor

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research Regulation of Tmem30b-mediated apical membrane homeostasis in auditory outer hair cells is critical for hearing

research Defining BMP functions in the hair follicle by conditional ablation of BMP receptor IA

research Class IIa HDAC4 and HDAC7 cooperatively regulate gene transcription in Th17 cell differentiation

research Direct evidence supporting the existence of a helical dislocation in protofilament packing in the intermediate filaments of oxidized trichocyte keratin

research AGD1, a class 1 ARF‐GAP, acts in common signaling pathways with phosphoinositide metabolism and the actin cytoskeleton in controlling Arabidopsis root hair polarity

research HOMEOBOX PROTEIN 24 mediates the conversion of indole‐3‐butyric acid to indole‐3‐acetic acid to promote root hair elongation

research Faculty Opinions recommendation of The Venus flytrap trigger hair-specific potassium channel KDM1 can reestablish the K+ gradient required for hapto-electric signaling.

research Physical and Functional Interaction between the Vitamin D Receptor and Hairless Corepressor, Two Proteins Required for Hair Cycling

research Hairless Suppresses Vitamin D Receptor Transactivation in Human Keratinocytes

research WIF1 Is Expressed by Stem Cells of the Human Interfollicular Epidermis and Acts to Suppress Keratinocyte Proliferation

research Androgen receptor inhibits the hair follicle induction potential of dermal papilla cells by binding with Tcf4 at the A574 binding site

research Data from Activator Protein-1 Activity Regulates Epithelial Tumor Cell Identity

research Data from Activator Protein-1 Activity Regulates Epithelial Tumor Cell Identity

research GATA3 inhibits proliferation and induces expression of both early and late differentiation markers in keratinocytes of the human epidermis

research Myodegeneration in EDA-A2 Transgenic Mice Is Prevented by XEDAR Deficiency

research A novel calmodulin‐interacting Domain of Unknown Function 506 protein represses root hair elongation in Arabidopsis

research Androgen receptor transactivity is potentiated by TGF-β1 through Smad3 but checked by its coactivator Hic-5/ARA55 in balding dermal papilla cells

research In Vitro Assembly and Structure of Trichocyte Keratin Intermediate Filaments

research Intercellular Adhesion Molecule-1 and Hair Follicle Regression

research Interactions of the Vitamin D Receptor with the Corepressor Hairless

research L-Ornithine ketoacid-transaminase assay in hair roots of homozygotes and heterozygotes for gyrate atrophy

research Monilethrix: Mutational Hotspot in the Helix Termination Motif of the Human Hair Basic Keratin 6

research 320 Desmoglein 3-mediated mechanical transadhesion controls epithelial stem cell quiescence

research Two Different Mutations in the Same Codon of a Type II Hair Keratin (hHb6) in Patients with Monilethrix

research Loss-of-function mutations of an inhibitory upstream ORF in the human hairless transcript cause Marie Unna hereditary hypotrichosis

research A missense mutation in the type II hair keratin hHb3 is associated with monilethrix

research Endothelial NMMHC IIA dissociation from PAR1 activates the CREB3/ARF4 signaling in thrombin-mediated intracerebral hemorrhage

research Ligand‐independent Regulation of the hairless Promoter by Vitamin D Receptor^†

research Expression of Uncoupling Proteins in Human Skin and Skin-Derived Cells

research Molecular modeling and structural characterization of a high glycine–tyrosine hair keratin associated protein