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research Sequence of the intron/exon junctions of the coding region of the human androgen receptor gene and identification of a point mutation in a family with complete androgen insensitivity.

32 citations , November 2020 in “UNC Libraries”

A point mutation in the androgen receptor gene causes complete androgen insensitivity.

research Premature termination of hair follicle morphogenesis and accelerated hair follicle cycling in Iasi congenital atrichia (fz^ica) mice points to fuzzy as a key element of hair cycle control

20 citations , July 2005 in “Experimental dermatology”

The fuzzy gene is crucial for controlling hair growth cycles.

research 085 Coordinate expressions of cyclin-dependent kinase inhibitors and high sulfur protein in human hair follicles

June 1996 in “Journal of Dermatological Science”

research A Homozygous Nonsense Mutation in the Zinc-Finger Domain of the Human Hairless Gene Underlies Congenital Atrichia

37 citations , August 1999 in “Journal of Investigative Dermatology”

A specific gene mutation causes complete hair loss without other health issues.

Hair Keratin Associated Proteins: Characterization of a Second High Sulfur KAP Gene Domain on Human Chromosome 21 in Fond Memory of Dr. Peter Steinert

research Hair Keratin Associated Proteins: Characterization of a Second High Sulfur KAP Gene Domain on Human Chromosome 2111In fond memory of Dr Peter Steinert.

62 citations , January 2004 in “The journal of investigative dermatology/Journal of investigative dermatology”

A second domain of high sulfur KAP genes on chromosome 21q23 is crucial for hair structure.

research Calcineurin/Nfatc1 signaling links skin stem cell quiescence to hormonal signaling during pregnancy and lactation

40 citations , April 2014 in “Genes & Development”

Hormones during pregnancy and lactation keep skin stem cells inactive, preventing hair growth.

research Root hair growth from the pH point of view

8 citations , July 2022 in “Frontiers in plant science”

pH changes are crucial for root hair growth because they affect enzymes and proteins that control the cell wall and growth.

Das weiße Hautfettgewebe initiiert die IL-33-abhängige Expression von Interleukin 4/13 in myeloischen Zellen während einer Entzündung

research Das weiße Hautfettgewebe initiiert die IL-33-abhängige Expression von Interleukin 4/13 in myeloischen Zellen während einer Entzündung

August 2024 in “Qucosa (Saxon State and University Library Dresden)”

This study explores the role of dermal white adipose tissue (dWAT) in regulating acute skin inflammation, particularly through the IL-33-dependent expression of interleukin 4 and 13 in myeloid cells. Using an Imiquimod (IMQ) mouse model, the research shows that activated dWAT releases proinflammatory mediators that influence myeloid cells, crucial for inflammation regulation and tissue repair. IL-33 from dWAT is identified as a key stimulator of these cytokines, but obesity impairs this pathway, reducing IL-4 and IL-13 expression, which may contribute to chronic inflammation in obesity. These findings have implications for inflammatory conditions like atopic dermatitis and diabetic wound healing.

research Decision letter: Interplay of opposing fate choices stalls oncogenic growth in murine skin epithelium

February 2020

Skin cells can naturally limit the growth of cancerous changes by balancing cell renewal and differentiation.

research The Autoimmune Regulator (AIRE), Which Is Defective in Autoimmune Polyendocrinopathy-Candidiasis-Ectodermal Dystrophy Patients, Is Expressed in Human Epidermal and Follicular Keratinocytes and Associates With the Intermediate Filament Protein Cytokeratin 17

24 citations , February 2011 in “The American journal of pathology”

AIRE protein, defective in APECED patients, is found in skin and hair cells and interacts with cytokeratin 17.

research A Mutational Hotspot in the 2B Domain of Human Hair Basic Keratin 6 (hHb6) in Monilethrix Patients

34 citations , November 1998 in “Journal of Investigative Dermatology”

A common mutation in the hHb6 gene is linked to monilethrix, but other factors may also play a role.

research Decision letter: Structural basis of malodour precursor transport in the human axilla

March 2018

The study identified a key protein involved in producing underarm odor and found ways to inhibit it.

K15 Promoter-Driven Enforced Expression of NKIRAS Exhibits Tumor Suppressive Activity Against the Development of DMBA/TPA-Induced Skin Tumors

research K15 promoter-driven enforced expression of NKIRAS exhibits tumor suppressive activity against the development of DMBA/TPA-induced skin tumors

4 citations , October 2021 in “Scientific Reports”

NKIRAS2 can suppress certain skin tumors but its effect on cancer varies with context and expression level.

Yin and Yang of Hair Cells: The Role of Activin A and Follistatin in Inner Ear Development

research Yin and yang of hair cells

July 2019 in “Science”

Activin A increases inner ear hair cell development, while follistatin decreases it.

research Discovery of COVID-19 Inhibitors Targeting the SARS-CoV2 Nsp13 Helicase

18 citations , August 2020 in “bioRxiv (Cold Spring Harbor Laboratory)”

Two existing drugs may help treat COVID-19 by inhibiting a key viral protein.

research Type 1 interferon signature and cytotoxic T lymphocyte activation targeted against sweat ducts in inflammatory acquired idiopathic generalized anhidrosis

6 citations , June 2023 in “Journal of the European Academy of Dermatology and Venereology”

Inflammation damages sweat ducts, causing sweat gland injury.

research 332 OTULIN maintains skin homeostasis by controlling keratinocyte death and stem cell identity

November 2022 in “Journal of Investigative Dermatology”

ILC1-like cells can cause alopecia areata by affecting hair follicles.

Ionizing Radiation Triggers Dedifferentiation of Outer Root Sheath Cells Into Stem Cell-Like Progenitors for Hair Follicle Regeneration

research 881 Ionizing radiation triggers dedifferentiation of outer root sheath cells into stem cell-like progenitors for hair follicle regeneration

April 2017 in “Journal of Investigative Dermatology”

Crystallization and Preliminary X-Ray Analysis of the Human Androgen Receptor Ligand-Binding Domain with a Coactivator-Like Peptide and Selective Androgen Receptor Modulators

research Crystallization and preliminary X-ray analysis of the human androgen receptor ligand-binding domain with a coactivator-like peptide and selective androgen receptor modulators

1 citations , November 2008 in “Acta crystallographica”

Scientists successfully created and analyzed the structure of a part of the human androgen receptor with specific modulators and a peptide to understand how it binds differently in various tissues.

research The Role of ATP-dependent Chromatin Remodeling in the Control of Epidermal Differentiation and Skin Stem Cell Activity

January 2018 in “Stem cell biology and regenerative medicine”

ATP-dependent chromatin remodeling is crucial for skin development and stem cell function.

research BPS2026 – TMC1 and TMC2 are cholesterol-dependent scramblases that regulate membrane homeostasis in auditory hair cells

February 2026 in “Biophysical Journal”

research A novel mutation in Hr causes abnormal hair follicle morphogenesis in hairpoor mouse, an animal model for Marie Unna Hereditary Hypotrichosis

21 citations , June 2009 in “Mammalian genome”

A new mutation in the Hr gene causes hair loss in mice, similar to a human hair disorder.

research Dermal EZH2 simultaneously orchestrates dermal differentiation and epidermal proliferation during murine skin development

November 2020 in “bioRxiv (Cold Spring Harbor Laboratory)”

Dermal EZH2 controls skin cell growth and differentiation in mice.

research More than One Gene Involved in Monilethrix: Intracellular but also Extracellular Players

35 citations , May 2006 in “Journal of Investigative Dermatology”

Monilethrix involves multiple genes affecting hair structure, including DSG4 mutations.

research Histopathological Analysis on keratin2-6 g Expression in Hair Mutant Mouse Hague

January 2002 in “Proceedings of The Japanese Society of Animal Models for Human Diseases”

Keratin2-6g is crucial for hair follicle development, with mutations causing cell degeneration and vacuolation.

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