April 2023 in “bioRxiv (Cold Spring Harbor Laboratory)” Sweat gland development involves two unique skin cell programs and a temporary skin environment.
34 citations
,
July 2006 in “The Journal of Comparative Neurology” Increasing neurotrophin 4 in skin boosts nerve endings but not sensory neuron count.
15 citations
,
May 2013 in “American Journal of Medical Genetics - Part A” People with X-linked hypohidrotic ectodermal dysplasia have no sweat ducts and less, thinner hair.
47 citations
,
January 2003 in “Pharmaceutical Research” October 2014 in “Archivio Istituzionale della Ricerca (Universita Degli Studi Di Milano)” A new type of nerve cell involved in itch perception was discovered.
April 2017 in “The journal of investigative dermatology/Journal of investigative dermatology” HSD11b1 affects skin nerves and increases non-histaminergic itch.
5 citations
,
January 1983 in “PubMed” Human skin releases different steroids, with some coming from sebaceous glands and others from sweat glands.
63 citations
,
February 2010 in “Journal of Neurophysiology” Microstimulation of certain facial and mouth nerves can evoke specific sensations, while deeper nerves may require multiple stimulations to affect perception.
47 citations
,
May 1994 in “Experimental Brain Research” The mystacial pad's innervation in adult rats is more complex than previously thought.
The sympathetic nervous system is linked to scalp hair loss.
Different botulinum toxin products and concentrations can effectively reduce sweating, itching, bladder pressure, hair loss, and muscle spasms.
33 citations
,
October 2013 in “PloS one” Human sweat glands have a type of stem cell that can grow well and turn into different cell types.
5 citations
,
March 2023 in “bioRxiv (Cold Spring Harbor Laboratory)” Dynamic, light touch is sensed through a common mechanism involving Piezo2 channels in sensory axons.
1 citations
,
September 2025 in “Physiologia” Ovalbumin–aluminum sensitization causes increased pain sensitivity and nerve changes in mice.
109 citations
,
April 1997 in “Archives of Dermatological Research” Mast cell and nerve fiber interactions in mouse skin change with the hair cycle.
February 2026 in “Contact Dermatitis” Avoiding exposure to certain grasses can prevent skin allergies, highlighting the importance of proper sanitation.
January 2004 in “Side effects of drugs annual” Certain skin drugs and topical agents, including some natural extracts and fragrances, can cause allergic reactions. Some hair dyes and extensions, as well as minoxidil, a hair growth treatment, can also cause allergies. Botulinum toxin A can effectively reduce sweat but may have temporary side effects.
December 2014 in “Actas dermo-sifiliográficas/Actas dermo-sifiliográficas” Hair removal with intense pulsed light can cause rare skin lesions that are hard to fully treat.
99 citations
,
August 1998 in “Pain” Blocking GABA(A) receptors increases neuron sensitivity, showing GABA and glycine have different roles in pain.
September 2024 in “Journal of the American Academy of Dermatology” Oxytocin receptors are found in skin cells near touch and pain neurons.
A runner developed tangled armpit hairs from shirt friction, preventable by shaving or wearing smooth shirts.
18 citations
,
June 2014 in “Anais Brasileiros de Dermatologia” Clouston Syndrome can be linked to rare sweat gland tumors.
61 citations
,
June 2018 in “Proceedings of the National Academy of Sciences of the United States of America” Light can turn on hair growth cells through a nerve path starting in the eyes.
7 citations
,
July 2025 in “The Journal of Physiology” C-tactile nerves are sensitive to hair movement.
November 2025 in “Journal of Investigative Dermatology” Mesenchymal stiffness affects sweat gland cell development.
18 citations
,
March 2009 in “Medical Hypotheses” The document suggests that blocking sweat glands with antiperspirants might allow skin-generated hormones to be absorbed, possibly increasing breast and prostate cancer risk.
December 2025 in “Skin Appendage Disorders” Scalp apocrine glands may help remove waste and balance electrolytes, but their role is not fully understood.
November 2024 in “Journal of Investigative Dermatology” Skin and hair cells release serotonin and histamine naturally, which could help improve skin health.
30 citations
,
July 1993 in “Journal of Investigative Dermatology”
17 citations
,
September 2014 in “PLoS ONE” SK2 channels help control sensory signals in rat muscle spindles and hair follicles.