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GlossaryLymphocytes

type of white blood cell crucial for immune defense

Lymphocytes are a type of white blood cell that play a crucial role in the immune system by helping the body fight off infections and diseases. There are two main types: B cells, which produce antibodies to neutralize pathogens, and T cells, which destroy infected cells and coordinate the immune response.

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TCL1 Transgenic Mouse Model as a Tool for the Study of Therapeutic Targets and Microenvironment in Human B-Cell Chronic Lymphocytic Leukemia

research TCL1 transgenic mouse model as a tool for the study of therapeutic targets and microenvironment in human B-cell chronic lymphocytic leukemia

38 citations , January 2016 in “Cell Death and Disease”

The TCL1 transgenic mouse model is useful for understanding human B-cell leukemia and testing new treatments.

research Epigallocatechin-3 Gallate Inhibits STAT-1/JAK2/IRF-1/HLA-DR/HLA-B and Reduces CD8 MKG2D Lymphocytes of Alopecia Areata Patients

15 citations , December 2018 in “International journal of environmental research and public health/International journal of environmental research and public health”

EGCG may help treat alopecia areata by blocking certain immune responses and reducing specific harmful immune cells.

research Canine and Feline Cutaneous Lymphocytosis: Reactive Process or Indolent Neoplastic Disease?

1 citations , December 2021

Cats likely have a reactive skin condition, while dogs may have a more complex, possibly cancerous one.

research 0977 Pathogenic hallmarks of primary lymphocyte-mediated scarring alopecia revealed by single nuclear and spatial multiomics

July 2025 in “Journal of Investigative Dermatology”

Scarring alopecia involves increased immune cells and specific gene changes near damaged hair follicles.

research Follicular mycosis fungoides mimicking a cutaneous B‐cell lymphoproliferative disorder

14 citations , July 2004 in “Australasian Journal of Dermatology”

Follicular mycosis fungoides can look like a B-cell lymphoma, making diagnosis difficult.

research Clinical, morphological and immunohistochemical characterization of cutaneous lymphocytosis in 23 cats

35 citations , February 2004 in “Veterinary Dermatology”

Cutaneous lymphocytosis in cats is a slowly progressing, relatively benign disease affecting older cats, often causing skin lesions and systemic signs.

research Functional interrogation of lymphocyte subsets in alopecia areata using single-cell RNA sequencing

23 citations , July 2023 in “Proceedings of the National Academy of Sciences”

CD8+ T cells drive alopecia areata, while regulatory T cells are protective.

research Bendamustine: an Old Drug in the New Era for Patients with Non-Hodgkin Lymphomas and Chronic Lymphocytic Leukemia

9 citations , January 2018 in “Acta Clinica Croatica”

Bendamustine, often combined with other drugs, is effective and less toxic for certain blood cancers, but less effective for young, fit patients with CLL.

research Teriflunomide and Its Mechanism of Action in Multiple Sclerosis

253 citations , April 2014 in “Drugs”

Teriflunomide helps reduce multiple sclerosis symptoms and is safe for most patients.

research Exploring the Drug Repurposing Versatility of Valproic Acid as a Multifunctional Regulator of Innate and Adaptive Immune Cells

47 citations , March 2019 in “Journal of immunology research”

Valproic Acid could potentially be used to treat immune-related conditions due to its ability to modify immune cell functions.

research Alopecia frontal posmenopáusica

8 citations , January 2002 in “Piel”

Postmenopausal women may experience frontal hairline and eyebrow loss due to cicatricial fibrosis.

research Good efficacy achieved by telitacicept in treatment of systemic lupus erythematosus with alopecia areata

June 2024 in “Archives of Medical Science”

Telitacicept effectively improved hair regrowth in a woman with lupus and alopecia.

research M-CSF-Stimulated CD11b+ Myeloid Cells Induce Alopecia Areata in C3H/HeJ Mice

December 2021 in “Research Square (Research Square)”

M-CSF-stimulated myeloid cells can cause alopecia areata in mice.

research Primary cutaneous follicle center lymphoma presenting as frontal fibrosing alopecia

September 2025 in “Dermatology Online Journal”

Biopsy is crucial for diagnosing unusual hair loss causes like lymphoma.

research Identification of drug-specific public TCR driving severe cutaneous adverse reactions

88 citations , August 2019 in “Nature communications”

Researchers found a specific immune receptor in patients that causes severe skin reactions to a drug.

research Vaccines, Infections, and Alopecia Areata

May 2015

Some vaccines, like the hepatitis B vaccine, might be linked to the hair loss condition Alopecia Areata, but more research is needed.

research Renbök Phenomenon and Contact Sensitization in a Patient With Alopecia Universalis

18 citations , April 2010 in “Archives of Dermatology”

Psoriasis or contact dermatitis can override alopecia areata, allowing hair growth.

research Th1/Th2 PB balance and CD200 expression of patients with active severe alopecia areata

12 citations , April 2017 in “Experimental and Therapeutic Medicine”

Patients with severe active alopecia areata have lower CD200 expression and an imbalance in their immune system.

Reversal of Alopecia Areata in a Mouse Model of Human Hair Loss by Daily Dietary Administration of a Proprietary Extract of North American Ginseng (Panax Quinquefolius)

research Reversal of alopecia areata in a mouse model of human hair loss by daily dietary administration of a proprietary extract of North American ginseng (Panax Quinquefolius)

January 2015

North American ginseng extract helped regrow hair in balding mice.

research Trichoblastic Carcinoma (“Malignant Trichoblastoma”) with Lymphatic and Hematogenous Metastases

80 citations , June 2000 in “Modern Pathology”

Long-standing benign tumors can become cancerous, especially in people with weakened immune systems.

research Leukemia cutis of the scalp masquerading as 'Kerion' in a child

January 2023 in “Indian dermatology online journal”

Leukemia can sometimes appear as unusual skin issues in children.

research Ectrodactyly, Ectodermal Dysplasia, and Cleft Lip/Palate Syndrome with Concomitant Lymphopenia: A Novel TP63 Mutation

February 2016 in “The journal of allergy and clinical immunology/Journal of allergy and clinical immunology/The journal of allergy and clinical immunology”

A new TP63 mutation was found in a baby with EEC syndrome, showing the need for TREC testing to check for immune issues.

research Alopecia universalis as a side effect of pegylated interferon α-ribavirin combination therapy for hepatitis C: a rare case report

6 citations , October 2016 in “Journal of Chemotherapy”

A man lost all his hair as a rare side effect after hepatitis C treatment.

research [Differences in efficacy between drug-eluting beads transbronchial arterial chemoembolization combined with systemic chemotherapy and systemic chemotherapy alone for unresectable lung squamous cell carcinoma].

3 citations , April 2020 in “PubMed”

Combining DEB-BACE with chemotherapy is more effective and has fewer side effects than chemotherapy alone for treating unresectable lung squamous cell carcinoma.