3 citations
,
September 2023 in “Stem Cell Research & Therapy” Researchers successfully differentiated human embryonic stem cells (hESCs) into functional and long-lived melanocytes by transiently expressing JMJD3. These melanocytes maintained their growth rate for approximately 200 days, demonstrated key functions such as melanogenesis and melanin transfer, and showed high engraftability and biocompatibility in immunodeficient mice. The study highlights the potential of using pluripotent stem cells to develop clinical applications for treating pigmentary skin disorders like vitiligo, which affects 0.1–2.0% of the global population. The differentiation protocol's simplicity enhances its potential for clinical use, addressing challenges in obtaining sufficient melanocytes for transplantation.
March 2013 in “Actas Dermo-Sifiliográficas” The document concludes that there have been significant improvements in diagnosing and treating skin diseases, including melanoma, with new techniques and therapies.
21 citations
,
February 2006 in “Clinical Cancer Research” Mitf plays a key role in melanoma progression and is linked to disease stage.
![[4-t-Butylphenyl]-N-(4-imidazol-1-yl phenyl)sulfonamide (ISCK03) Inhibits SCF/c-kit Signaling in 501mel Human Melanoma Cells and Abolishes Melanin Production in Mice and Brownish Guinea Pigs](/images/research/4eb017dc-711d-4926-bcd0-c3b8f48e3a99/small/19974.jpg)
26 citations
,
July 2007 in “Biochemical Pharmacology” ISCK03 stops melanin production in human melanoma cells and lightens skin color in mice and guinea pigs.
24 citations
,
December 2011 in “Journal of The American Academy of Dermatology” Melanoma survivors are more likely to use sunscreen and seek shade than others, but less than half often use sunscreen and avoid the sun, and some still use tanning beds.
The treatment was ineffective in humans.
11 citations
,
March 2014 in “Journal of Investigative Dermatology” Genetic mutation and carcinogen treatment are both needed for skin cancer to develop in these specific mice.
1 citations
,
October 2023 in “European Journal of Dermatology” Combining hair transplantation with PRP is more effective for treating hair loss than hair transplantation alone.
April 2019 in “Institutional Repositories DataBase (IRDB)” Patient-derived stem cell melanocytes could be a promising treatment for vitiligo.
September 2025 in “Arthritis Research & Therapy” BMS-470539 reduces skin fibrosis and inflammation.
2 citations
,
August 2017 in “Experimental Dermatology” A human serum-enriched medium effectively supports melanocyte growth and activity without using animal-derived supplements.
2 citations
,
May 2008 in “Journal of Clinical Oncology” AZD6244 treatment causes skin aging effects by depleting skin stem cells.
August 2025 in “Dermatology Reports” Melanoma research shifted focus to immunotherapy drugs after 2010, increasing their study and citations.
Suppressing ODC activity reduces tumor growth in hair follicles.
March 2009 in “Chinese Journal of Dermatology” Melanocytes in the outer root sheath are likely stem cells that grow fast but stay immature.
1 citations
,
August 2024 in “Heliyon” Hair follicle stem cells can become melanocytes to help treat skin depigmentation.
November 2022 in “Journal of Investigative Dermatology” Skin aging and cancer development are influenced by the competition between stem cells.
January 2008 in “Projeto: revista mensal de arquitetura” Targeted cancer drugs can cause skin reactions, so dermatologists must manage these effects.
1 citations
,
June 2015 in “Cancer” Finasteride and dutasteride may lower melanoma risk, with teenage acne possibly indicating higher risk.
5 citations
,
October 2021 in “Journal of the American Academy of Dermatology” PRAME helps distinguish between benign and malignant skin cells in most cases.
August 2024 in “Animal Bioscience” Exosomal miR-222-3p reduces melanin production in rabbits by targeting the SOX10 gene.
1 citations
,
June 2011 in “InTech eBooks” Darker skin provides more protection against UV damage and cancer.
11 citations
,
February 2023 in “Journal of Investigative Dermatology” Low m6Ascores in melanoma predict better survival and response to immunotherapy.
July 2019 in “Tumor Biology” Bone marrow-derived cells contribute to skin tumors, suggesting new treatment targets for non-melanoma skin cancers.
September 2022 in “Scientific Reports” Scalp melanoma is more common and easier to diagnose early in people with androgenetic alopecia due to sun damage.
10 citations
,
July 2013 in “British Journal of Dermatology” High MUC-18/MCAM levels in blood indicate a worse outlook for melanoma patients.
153 citations
,
April 1998 in “Current Biology” The risk of skin tumors becoming malignant depends on the specific skin cell type affected.
1 citations
,
August 2022 in “Pigment Cell & Melanoma Research” New mouse models help study melanocytic cells for melanoma research.
3 citations
,
April 2012 in “Cancer research” Mouse skin cancer progression involves a unique group of cells marked by ABCG2 and MTS24.
April 2019 in “Journal of Investigative Dermatology” The created skin model with melanoblasts improves the study of skin color and offers an alternative to animal testing.