227 citations
,
January 1998 in “Journal of Endocrinology” Cells from balding scalps have more androgen receptors than cells from non-balding scalps.
171 citations
,
July 2007 in “Journal of Investigative Dermatology” A substance called DKK-1 increases in balding areas and causes hair cells to die when exposed to DHT.
141 citations
,
November 2007 in “Journal of Investigative Dermatology” Balding cells age faster due to stress, suggesting stress-targeting treatments for hair loss.
137 citations
,
May 1984 in “Journal of Investigative Dermatology” Minoxidil increases blood flow in balding scalps, possibly reversing hair loss.
46 citations
,
April 2016 in “Journal of Investigative Dermatology” New genes found linked to balding, may help develop future treatments.
29 citations
,
July 2020 in “Journal of The American Academy of Dermatology” Men with severe balding have a higher risk of getting very sick from COVID-19.
23 citations
,
December 1991 in “Annals of the New York Academy of Sciences” Balding scalps slow down hair growth.
22 citations
,
March 1994 in “Journal of Heredity” A mutation in mice causes hair loss and immune problems.
17 citations
,
May 2003 in “Journal of The American Academy of Dermatology” Hair from balding and non-balding areas regrows similarly on mice.
14 citations
,
April 2007 in “Journal of aging and health” Balding men had lower bone density, while balding women had higher hip bone density.
8 citations
,
April 2001 in “Dermatologic Surgery” Michael L. Beehner proposed a standardized way to describe balding areas on the scalp to help hair restoration experts communicate better.
1 citations
,
October 2020 in “Journal of The American Academy of Dermatology” Balding might help identify men at higher risk for severe COVID-19, but more research is needed.
Hair loss should be medically treated, as non-medical treatments are ineffective and hair loss can indicate serious health issues.
June 2024 in “Archives of Dermatological Research” SFRP2 and PTGDS may be key factors in female hair loss.
Balding in men worsens with age.
November 2022 in “Journal of Investigative Dermatology” The research found specific genes that are more active in balding cells, which could be causing hair loss.
September 2019 in “Journal of Investigative Dermatology” Dermal Papilla Cells grown in 3D and with stem cells better mimic natural hair growth conditions than cells grown in 2D.
Neurotrophins may contribute to genetic hair thinning by inhibiting hair growth.
Balding hair follicles have reduced growth factors and increased inhibitory factors, suggesting new treatment paths for hair loss.
13 citations
,
September 2011 in “Archives of dermatology” A patient with steroid sulfatase deficiency had a unique hair pattern and a brain malformation not previously linked to the condition.
124 citations
,
April 1992 in “Journal of Endocrinology/Journal of endocrinology” Beard hair follicles have more androgen receptors than non-balding scalp hair follicles.
29 citations
,
February 2004 in “Experimental and Clinical Endocrinology & Diabetes” Men with early balding often have hormone levels similar to women with polycystic ovary syndrome.
26 citations
,
June 2000 in “Journal of The American Academy of Dermatology” Men with balding at age 45 had higher IGF-1 and lower IGFBP-3, suggesting these factors might be important in male pattern baldness.
13 citations
,
November 2010 in “Experimental Dermatology” Vitamin C derivative reduces hair loss-related protein in cells.
6 citations
,
September 2020 in “Journal of The American Academy of Dermatology” Severe male balding may increase the risk of serious COVID-19, and treatments that reduce androgens or block a specific enzyme might help protect these individuals.
3 citations
,
June 2000 in “Journal of The American Academy of Dermatology” Men with balding at age 45 had higher IGF-1 and lower IGFBP-3 levels, suggesting these factors might influence male pattern baldness.
2 citations
,
October 2020 in “Journal of The American Academy of Dermatology” The authors suggest that scalp hair might protect against COVID-19 and call for more research on scalp health and the virus.
March 2022 in “Journal of The American Academy of Dermatology” The study found different balding patterns in men of color.
38 citations
,
September 1997 in “The journal of investigative dermatology/Journal of investigative dermatology” A mutation in mice causes hair loss and skin issues due to a defect in a gene affecting cell adhesion.
31 citations
,
October 2010 in “BMB Reports” L-threonate may help prevent balding by blocking a key protein.