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research Novel modulatory effects of neurosteroids and benzodiazepines on excitatory and inhibitory neurons excitability: a multi-electrode array recording study

19 citations , January 2012 in “Frontiers in Neural Circuits”

Neurosteroids and benzodiazepines reduce neuron excitability, with lasting effects on inhibitory neurons.

research Crystal Structure of 17-.BETA.-Benzoyloxy-16-.BETA.-methylpregna-4,6-diene-3,20-dione.

February 1999 in “Analytical Sciences”

A new antiandrogen compound was made and its detailed three-dimensional shape was described.

Synthesis and Biological Evaluation of Amino-Pyridines as Androgen Receptor Antagonists for Stimulating Hair Growth and Reducing Sebum Production

research Synthesis and biological evaluation of amino-pyridines as androgen receptor antagonists for stimulating hair growth and reducing sebum production

17 citations , August 2007 in “Bioorganic & Medicinal Chemistry Letters”

A compound made by Pfizer can potentially stimulate hair growth and reduce oil production, making it a good candidate for topical use.

Natural Bisbenzylisoquinoline Derivatives Protect Zebrafish Lateral Line Sensory Hair Cells from Aminoglycoside Toxicity

research Natural Bizbenzoquinoline Derivatives Protect Zebrafish Lateral Line Sensory Hair Cells from Aminoglycoside Toxicity

44 citations , March 2016 in “Frontiers in cellular neuroscience”

Some natural compounds can protect fish ear cells from damage by certain antibiotics without affecting the antibiotics' ability to fight infections.

research The Bis(1,2,3,4-tetrahydroisoquinoline) Alkaloids Cepharanthine and Berbamine Are Ligands of SK Channels

6 citations , January 2024 in “ACS Medicinal Chemistry Letters”

Cepharanthine and berbamine may affect SK channels, influencing their therapeutic effects.

research Reaction of Finasteride Intermediate with Benzeneseleninic Anhydride: An In-Depth Study

2 citations , November 2008 in “Industrial & Engineering Chemistry Research”

Impure benzeneseleninic anhydride samples cause lower finasteride intermediate yields.

research Breaking the “rule-of-five” to access Bridged Bicyclic Heteroaromatic Bioisosteres

3 citations , May 2025

A new method creates valuable compounds for drug discovery by breaking traditional chemical rules.

research Molecular docking simulation studies on potent butyrylcholinesterase inhibitors obtained from microbial transformation of dihydrotestosterone

8 citations , October 2013 in “Chemistry Central Journal”

Metabolite 7 is a strong inhibitor for Alzheimer's disease management.

Nonsteroidal Inhibitors of Human Type I Steroid 5α-Reductase

research Nonsteroidal inhibitors of human type I steroid 5-.alpha.-reductase

89 citations , February 1993 in “Journal of Medicinal Chemistry”

New compounds called benzoquinolinones may treat conditions linked to excess DHT.

research Synthesis of 4-amidinoimidazoles incorporating a cyanamide moiety : novel precursors for biologically important purines

November 2012 in “Journal of Clinical Pathology”

Synthesis and Biological Evaluation of 4-(4-(Alkyl- and Phenylaminocarbonyl)benzoyl)benzoic Acid Derivatives as Non-Steroidal Inhibitors of Steroid 5α-Reductase Isozymes 1 and 2

research Synthesis and Biological Evaluation of 4-(4-(Alkyl-and Phenylaminocarbonyl)benzoyl)benzoic Acid Derivatives as Non-steroidal Inhibitors of Steroid 5α-Reductase Isozymes 1 and 2

8 citations , March 2002 in “Archiv Der Pharmazie”

The compound 4c effectively inhibits the enzyme linked to hair loss.

research Design, Synthesis and Anxiolytic Activity Evaluation of N-Acyltryptophanyl- Containing Dipeptides, Potential TSPO Ligands#

16 citations , November 2018 in “Medicinal Chemistry”

The compound GD-23 may reduce anxiety like diazepam by targeting the TSPO receptor.

research The leaves of Crataeva nurvala Buch-Ham. modulate locomotor and anxiety behaviors possibly through GABAergic system

16 citations , October 2018 in “BMC Complementary and Alternative Medicine”

Crataeva nurvala leaves may help reduce anxiety and improve sleep.

research Synthesis and Evaluation of 2‘-Substituted 4-(4‘-Carboxy- or 4‘-carboxymethylbenzylidene)-N-acylpiperidines: Highly Potent and in Vivo Active Steroid 5α-Reductase Type 2 Inhibitors

22 citations , June 2002 in “Journal of Medicinal Chemistry”

Compounds 15, 20, and 25 are strong inhibitors of human steroid 5α-reductase type 2.

research Synthetic studies toward the development of novel minoxidil analogs and conjugates with polyamines

12 citations , February 2010 in “Tetrahedron Letters”

New minoxidil compounds with better water solubility were made, but their full effects and safety need more research.

research Role of Neurosteroidogenic Pathways in the Antiseizure Activity of Midazolam in the 6‐Hz and Kindling Models of Epilepsy

April 2015 in “The FASEB Journal”

Midazolam's antiseizure effects are mainly due to synaptic GABA-A receptors, not neurosteroids or extrasynaptic receptors.

Synthesis of Novel Androstane-N-Cyclohexyl-17-Carboxamides and Their Effect on 5α-Reductase Isoform 2, Androgen Receptor, and Androgen-Dependent Glands

research Synthesis of novel andostane-N-cyclohexyl-17-carboxamides, and their effect on the 5α-reductase isoform 2, the androgen receptor, and androgen-dependent glands

November 2021 in “Pharmaceutical Sciences”

New compounds were made and tested, with compound 6 showing potential for treating prostate-related diseases.

research Synthesis, Biological Evaluation and in silico Studies of Novel 5α-aza-Bhomo-3,5-secosteroids as Potential 5-reductase Inhibitors

October 2016 in “Letters in Drug Design & Discovery”

research 13C-NMR study of 4-azasteroids in solution and solid state

25 citations , June 2002 in “Steroids”

4-azasteroids, including finasteride, can inhibit 5α-reductase, helping treat conditions like enlarged prostate and hair loss.

research Docking and Molecular Dynamics Identify Leads against 5 Alpha Reductase 2 for Benign Prostate Hyperplasia Treatment

10 citations , March 2023 in “Journal of Chemistry”

New compounds show promise for treating benign prostate hyperplasia with fewer side effects.

Bisphenol-A Antagonizes the Rapidly Modulating Effect of Dihydrotestosterone on Spinogenesis and Long-Term Potentiation of Hippocampal Neurons

research Bisphenol-A antagonizes the rapidly modulating effect of DHT on spinogenesis and long-term potentiation of hippocampal neurons

10 citations , December 2017 in “Chemosphere”

Bisphenol-A (BPA) increases connections between brain cells and boosts their activity, but it blocks the effects of a male hormone on brain cell plasticity.

research Preparation, Characterization and Molecular Docking Study of some New Pyrazole Derivatives Derived from 2-Mercaptobenzothiazole.

June 2025 in “Mağallaẗ ʻulūm al-rāfidayn”

New pyrazole derivatives may help treat hair loss, but more testing is needed.

The Importance of Pharmaceutical Care in the Face of Increasing Prescription and Indiscriminate Use of Anxiolytics with a Focus on Benzodiazepines and Passiflora Incarnata L.

research A IMPORTÂNCIA DA ATENÇÃO FARMACÊUTICA DIANTE DO AUMENTO DA PRESCRIÇÃO E USO INDISCRIMINADO DE ANSIOLÍTICOS COM FOCO NOS BENZODIAZEPÍNICOS E NA PASSIFLORA INCARNATA L.

January 2023 in “Brazilian Journals Editora eBooks”

Pharmacists play a key role in managing the use of anxiety medications and ensuring patients use them correctly.

research Synthesis of N-Substituted 3-Oxo-17b- carboxamide-4-aza-5a-androstanes and the Tautomerism of 3-Oxo-4-aza-5-androstenes

4 citations , January 1998 in “Heterocycles”

Researchers made two new compounds that could be used for medicine.

research Participation of GABAA, GABAB receptors and neurosteroids in toluene-induced hypothermia: Evidence of concentration-dependent differences in the mechanism of action

17 citations , October 2012 in “European Journal of Pharmacology”

Toluene lowers body temperature through different mechanisms depending on the concentration.

Midazolam Ameliorates the Behavioral Deficits of a Rat Posttraumatic Stress Disorder Model Through Dual 18 kDa Translocator Protein and Central Benzodiazepine Receptor and Neurosteroidogenesis

research Midazolam Ameliorates the Behavior Deficits of a Rat Posttraumatic Stress Disorder Model through Dual 18 kDa Translocator Protein and Central Benzodiazepine Receptor and Neurosteroidogenesis

56 citations , July 2014 in “PLoS ONE”

Midazolam reduces PTSD-like behavior in rats by acting on specific brain receptors.

research Effect of flutamide and two novel synthetic steroids on GABA, glutamine and some oxidative stress markers in rat brain and prostate

2 citations , January 2011 in “Andrologia”

Flutamide and a new synthetic steroid affected brain and prostate chemicals and showed potential for treating androgen-related conditions and epilepsy.

research New Aromatic Esters of Progesterone as Antiandrogens

6 citations , April 2004 in “Journal of Enzyme Inhibition and Medicinal Chemistry”

New progesterone-based compounds can block male hormones.

Synthesis and In Vitro Study of 17β-[N-Ureylene-N,N′-Disubstituted]-4-Methyl-4-Aza-5α-Androstan-3-Ones as Selective Inhibitors of Type I 5α-Reductase

research Synthesis and in vitro study of 17β-[N-ureylene-N,N′-disubstituted]-4-methyl-4-aza-5α-androstan-3-ones as selective inhibitors of type I 5α-reductase

5 citations , February 1997 in “Bioorganic & Medicinal Chemistry”

New compounds were made that effectively block a specific enzyme related to androgen conditions.

research Charting the Bromodomain BRD4: Towards the Identification of Novel Inhibitors with Molecular Similarity and Receptor Mapping

10 citations , November 2017 in “Letters in drug design & discovery”

Researchers identified promising inhibitors for the BRD4 protein, including finasteride and amentoflavone.

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