27 citations
,
April 1992 in “Biochemical Journal” Minoxidil reduces lysine hydroxylase in skin cells.
27 citations
,
September 2015 in “Drug Design Development and Therapy” Collagenase IV is crucial for hair growth by affecting key growth factors.
10 citations
,
November 2018 in “Genetics in medicine” Lack of cystatin M/E causes thin hair and dry skin.
9 citations
,
October 1946 in “Experimental biology and medicine” Rats fed soybean oil meal lost hair, but adding inositol, biotin, cystine, or methionine to their diet prevented this and improved growth.
The conclusion is that hair supplement ingredients may be unsafe and should be disclosed and proven safe before use.
February 2022 in “Journal of Biomedical Nanotechnology” Shikonin, a small molecule, speeds up burn wound healing and hair growth by activating the PI3K/Akt pathway.
34 citations
,
July 1958 in “Biochimica et Biophysica Acta”
Nanozymes can restore hair growth by fixing peroxisomal function.
1 citations
,
June 2019 in “Current developments in nutrition” A combination of arginine silicate complex and magnesium biotinate improves hair and nail growth in rats.
April 2016 in “Journal of Investigative Dermatology” A peptide known for reducing wrinkles also effectively inhibits an enzyme linked to skin inflammation and acne.
A natural compound called VB-1 can help promote hair growth by boosting a specific cell signal in human skin cells.
19 citations
,
March 1961 in “Nature” A fatty acid/protein complex in human hair helps protect it from damage.
April 2010 in “Cancer Research” Basal cell carcinomas may use IDO to protect themselves from the immune system.
37 citations
,
January 2002 in “British journal of dermatology/British journal of dermatology, Supplement” Apple extract called procyanidin B-2 was found to greatly increase hair growth.
January 2009 in “ScholarlyCommons (University of Pennsylvania)” The P133R mutation in AKR1D1 enzyme causes harmful bile acid buildup, explaining related health issues.
October 2025 in “Phytochemistry Letters”
September 2019 in “The journal of investigative dermatology/Journal of investigative dermatology” Not having enough cystatin M/E protein causes less hair growth and dry skin.
10 citations
,
January 2001 in “ACTA HISTOCHEMICA ET CYTOCHEMICA” Lysosomal proteases and cytoplasmic enzymes help hair follicle cells develop and differentiate.
5 citations
,
June 2024 in “Experimental Dermatology” High beta-hydroxybutyrate levels may worsen hair loss in alopecia areata.
9 citations
,
April 1970 in “Biochemical pharmacology” Stilbamidine and hydroxystilbamidine inhibit enzyme release from lysosomes and have effects similar to cortisol and chloroquine.
135 citations
,
October 1997 in “Journal of biological chemistry/The Journal of biological chemistry” Trichohyalin is modified by enzymes to form strong structures in hair cells.
April 2019 in “Journal of the Endocrine Society” An over-the-counter vitamin/mineral supplement improved hair loss and blood sugar control in a woman with non-classic 11-hydroxylase deficiency.
26 citations
,
January 1983 in “PubMed” Trichothiodystrophy involves brittle hair due to low sulfur amino acids, not a transport defect.
3 citations
,
January 2017 in “Journal of cosmetology & trichology” The food supplement with L-cystine, Serenoa repens extract, and biotin safely reduced hair loss and improved hair growth in men and women.
January 2025 in “The International Journal of Gastroenterology and Hepatology Diseases” Vitamin B12 is crucial for hair and nerve health, and its malabsorption can cause hair loss and nerve damage.
122 citations
,
January 2006 in “Molecular & Cellular Proteomics” Human hair contains many proteins, with some being highly abundant and modified.
June 2025 in “Rapid Communications in Mass Spectrometry” The new method improves protein extraction and analysis in hair, aiding biomedical and forensic work.
9 citations
,
January 2006 in “Cutaneous and ocular toxicology” L-cystine, D-pantothenat, and miliacin together significantly boost keratinocyte growth and metabolism.
11 citations
,
October 1941 in “Experimental Biology and Medicine” PABA helps prevent gray hair and hair loss in mice.
Newly designed proteins can effectively degrade specific proteins in cells, offering a promising alternative for targeted protein degradation.