research Grand challenges in dermatologic drug discovery: four priorities to transform skin disease treatment
Transforming skin disease treatment requires new strategies, better drug models, and patient-focused research.
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research Correction to: Toxicity of the pharmaceuticals finasteride and melengestrol acetate to benthic invertebrates
Finasteride and melengestrol acetate are toxic to benthic invertebrates.
research Data-driven strategies for drug repurposing: insights, recommendations, and case studies
Drug repurposing can speed up and reduce costs in drug discovery, especially for cancer treatment.
research Computational Drug Repositioning in Cardiorenal Disease: Opportunities, Challenges, and Approaches
Drug repositioning is a promising way to quickly develop new treatments, especially for rare diseases.
research Bioengineered Skin Intended as In Vitro Model for Pharmacosmetics, Skin Disease Study and Environmental Skin Impact Analysis
Bioengineered skin models help reduce animal testing and advance research in cosmetics and skin disease.
research Thiopurines: Recent Topics and Their Role in the Treatment of Inflammatory Bowel Diseases
Thiopurines help treat IBD but require genetic testing to avoid side effects.
research Poster Abstracts
The model and estimator can predict drug exposure in kidney transplant patients well.
research Pharmacological Mobilization of Endogenous Bone Marrow Stem Cells Promotes Liver Regeneration after Extensive Liver Resection in Rats
Using a drug to activate bone marrow stem cells can help the liver regenerate and function better after major surgery in rats.
research Effects of Acute UVB on Retinoid Metabolism
UVB exposure increases skin proteins for retinoic acid synthesis and shifts their location, possibly affecting skin repair.
research Selective inhibition of glucuronidation and sulfation in vitro and in vivo
research OPTIMASI FORMULA HAIR TONIC MIKROEMULSI BIOTIN (VITAMIN B7) DENGAN METODE FACTORIAL DESIGN
The best biotin hair tonic formula has 20% span 80, 9.47% tween 80, and 5% PEG 400.
research Simultaneous Target-Mediated Drug Disposition-Pharmacodynamic (TMDD-PD) Modeling of Finasteride and Dutasteride: Impact of Target Binding and Turnover on Non-linear Pharmacokinetics
Finasteride and dutasteride's effects are mainly due to target binding saturation and slow enzyme turnover.
research Flexible bioelectronic innovation for personalized health management
Flexible bioelectronics show promise in non-invasive cancer detection and treatment but need improvements in stability and effectiveness.
research Correction: Traditional Chinese Medicine Shi-Bi-Man regulates lactic acid metabolism and drives hair follicle stem cell activation to promote hair regeneration
research Bridging the organoid translational gap: integrating standardization and micropatterning for drug screening in clinical and pharmaceutical medicine
Standardizing and engineering organoids can improve their use in medicine and drug testing.
research The long road traveled in hematopoietic stem cell gene therapy
The FDA approved the first gene therapy for a blood disorder after overcoming early challenges and demonstrating patient benefits.
research In vivo Hair Growth Promotion Efficacy of Biofield Energy Treatment in C57BL/6 Mice
Biofield Energy Treatment may boost hair growth.
research Chemical Mechanism of the Covalent Modification of 5.alpha.-Reductases by Finasteride as Probed by Secondary Tritium Isotope Effects
Finasteride modifies 5-alpha-reductases through a two-step process, affecting inhibitor potency and possibly causing side effects.
research Revolutionizing Cosmetology With 3D Bioprinting: From Innovation to Application.
3D bioprinting is set to revolutionize cosmetics by enabling personalized and effective skin treatments.
research Expression of type 1 5α-reductase and metabolism of testosterone in reconstructed human epidermis (SkinEthic®): a new model for screening skin-targeted androgen modulators
The study created a new method to test drugs that affect hormone processing in skin.
research A MINI REVIEW ON PHOTO- BIOMODULATION- Novel approach
Photobiomodulation therapy shows promise in treating various health conditions by using specific light wavelengths.
research Drug repurposing: A novel strategy to target cancer stem cells and therapeutic resistance
Repurposing existing drugs and using micronutrients may effectively target cancer stem cells and improve cancer treatment.
research PROTACs in cancer therapy: targeted degradation of GPX4, PARP and epigenetic regulators
PROTACs show promise in cancer treatment by effectively degrading specific harmful proteins.
research Characterization of Recombinant Human Liver Thermolabile Phenol Sulfotransferase with Minoxidil as the Substrate
Both enzyme forms can sulfate minoxidil.
research The effect of St John’s wort on the pharmacokinetics and metabolism of finasteride in man
research Optimization and validation of spectrophotometric methods for determination of finasteride in dosage and biological forms
The methods accurately measure finasteride in different forms.
research THE COMPARISON OF THE BIOPHYSICAL SKIN PARAMETERS AND HAIR GROWTH IN THE PATIENTS WITH ACNE TREATED WITH ISOTRETINOIN AND BIOTIN OR ONLY ISOTRETINOIN TREATMENT
research Proteolysis‐Targeting Chimera (PROTAC): Current Applications and Future Directions
PROTACs offer new ways to treat hard-to-target diseases, with promising drugs for cancer in advanced trials.
research Nano-PROTACs: state of the art and perspectives
Nano-PROTACs could improve drug targeting and delivery by using nanotechnology.
research From Old to New: Trends in Drug Repurposing for Modern Medicine
Repurposing existing drugs can quickly and cheaply find new treatments for unmet medical needs.