research Steroidal 5α-reductase and 17α-hydroxylase/17,20-lyase (CYP17) inhibitors useful in the treatment of prostatic diseases
Certain drugs that block specific enzymes can help treat prostate diseases.
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research Modeling share dynamics by extracting competition structure
The model can predict website market shares by identifying competition among them.
research CD34 defines melanocyte stem cell subpopulations with distinct regenerative properties
CD34+ and CD34- melanocyte stem cells have different regenerative abilities.
research Lgr5 marks cycling, yet long-lived, hair follicle stem cells
Lgr5 is a marker for active, long-lasting stem cells in mouse hair follicles.
research Wnt Signaling, Lgr5, and Stem Cells in the Intestine and Skin
Lgr5 is a marker for active, self-renewing stem cells in the intestine and skin, important for tissue maintenance.
research An Ecologic Study of Disparities in COVID-19 Incidence and Case Fatality in Oakland County, MI, USA, During a State-Mandated Shutdown
COVID-19 affected Black communities more in Oakland County, MI, but didn't increase death rates.
research What Color Is the Skin of a Mouse?
Mouse skin color ranges from pink to black, depending on their hair growth cycle.
![Synthesis and Activity of 8-Substituted Benzo[c]quinolizin-3-ones as Dual Inhibitors of Human 5α-Reductases 1 and 2](/images/research/efc54340-66d6-4f27-9930-045ac023f903/small/15248.jpg)
research Synthesis and activity of 8-substituted benzo[c]quinolizin-3-ones as dual inhibitors of human 5α-reductases 1 and 2
New compounds were made that effectively block enzymes related to prostate issues and hair loss.
research Region-specific reversal of epidermal planar polarity in the rosette fancy mouse
Hair follicles in the back of the rosette fancy mouse have reversed orientations due to a gene mutation.
research Why Do Promising Therapies Stall in Development and How Can We Move Them Forward?
Most drugs fail to reach the market, but understanding their properties and using strategies like early toxicity tests and drug repurposing can help advance their development.
research Anagen effluvium
Hair usually grows back 1-3 months after treatment for anagen effluvium, and children with Loose Anagen Hair Syndrome often improve by adolescence.
research Fibroblast growth factor 5-short (FGF5s) inhibits the activity of FGF5 in primary and secondary hair follicle dermal papilla cells of cashmere goats
FGF5s can block the effects of FGF5, which may help control hair growth in cashmere goats.
research An analysis of canine hair re‐growth after clipping for a surgical procedure
Dog hair grows back in about 14 weeks after being clipped for surgery, and the season doesn't really affect this growth rate.
research The Effect of Anti-Androgens on the Response of Rat Preputial Glands to Testosterone*
New compounds can block testosterone effects in rats and might help treat conditions like prostate cancer and acne.
research Synthesis and in Vitro Evaluation of 4-Substituted N-(1,1-Dimethylethyl)-3-oxo-4-androstene-17.beta.-carboxamides as 5.alpha.-Reductase Inhibitors and Antiandrogens
The new compounds moderately block a specific enzyme and strongly counteract a male hormone, suggesting potential for treating certain male-related health conditions.
research Use of hair cortisol as a biomarker for chronic stress in pregnancy
Hair cortisol could be a marker for chronic stress in pregnancy, but depression affects cortisol levels differently.
research In the eye of the beholder
Cosmeceuticals may have potential but their effectiveness and market success are still uncertain.
research Flightless I Expression Enhances Murine Claw Regeneration Following Digit Amputation
Mice with more Flightless I protein grew back their claws better after amputation.
research Parathyroid hormone linked to a collagen binding domain promotes hair growth in a mouse model of chemotherapy-induced alopecia in a dose-dependent manner
A hormone linked to collagen helps hair grow back in mice after chemotherapy, and may also prevent bone loss.
research Human placenta induces hair regrowth in chemotherapy-induced alopecia via inhibition of apoptotic factors and proliferation of hair follicles
Human placenta helps hair grow back after chemotherapy by blocking cell death and increasing hair follicle growth.
research Expression and tissue distribution analysis of vimentin and transthyretin proteins associated with coat colors in sheep (Ovis aries)
Vimentin and transthyretin proteins are linked to black coat color in sheep.
research Hormone Blocking Anticancer Drugs
The document explains how certain drugs block hormones to treat cancers like breast and prostate cancer.
research Aging and Immortality: Quasi-Programmed Senescence and Its Pharmacologic Inhibition
The conclusion is that using drugs to block the TOR pathway might slow aging and prevent age-related diseases.
research Study of Postpartum Alopecia
Most new moms had their hair grow back within 4-6 months after childbirth, and hair loss is likely due to hormonal changes.
research Thy1 marks a distinct population of slow-cycling stem cells in the mouse epidermis
A specific group of slow-growing stem cells marked by Thy1 is crucial for skin maintenance and healing in mice.
research The Current Landscape for Direct-to-Consumer Genetic Testing: Legal, Ethical, and Policy Issues
The document concludes that the fast-growing direct-to-consumer genetic testing market lacks sufficient regulation, posing risks to consumers due to questionable test quality and accuracy.
research Effects of Visible Light on the Skin†
Visible light can damage skin and most sunscreens don't block it well; more research is needed on its effects and protection methods.
research Androgen receptor gene polymorphism and polycystic ovary syndrome
The conclusion is that androgen receptor gene polymorphism might be a marker for polycystic ovary syndrome, but more research is needed.
research Novel inhibitors of 5α-reductase
New research is needed to create better drugs that block the enzyme responsible for conditions like male baldness and prostate enlargement.
research 5α-Reductase Inhibitors, Chemical and Clinical Models
Researchers developed a model to predict how well certain compounds can block an enzyme related to hair loss and prostate issues, suggesting a 50 mg dose of finasteride might be effective based on lab and body data.