42 citations
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February 2021 in “Signal Transduction and Targeted Therapy” Hair follicle regeneration possible, more research needed.
35 citations
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August 2021 in “npj Regenerative Medicine” Fibroblasts, cells usually linked to tissue repair, also help regenerate various organs and their ability decreases with age. Turning adult fibroblasts back to a younger state could be a new treatment approach.
27 citations
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September 2018 in “Nanomedicine: Nanotechnology, Biology and Medicine” Further research is needed to improve hair regeneration using stem cells and nanomaterials.
21 citations
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November 2022 in “Frontiers in immunology” Sebaceous glands play a key role in skin health, immunity, and various skin diseases.
15 citations
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December 2020 in “International journal of molecular sciences” Epidermal stem cells create and maintain skin structures like hair and nails through specific signaling pathways and vary by location and function.
10 citations
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September 2018 in “Regenerative Medicine” New hair can grow from large wounds in mice, but less so as they age, involving reprogramming of skin cells and specific molecular pathways.
9 citations
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June 2016 in “Stem cells” Overexpression of sPLA2-IIA in mouse skin reduces hair stem cells and increases cell differentiation through JNK/c-Jun pathway activation.
3 citations
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May 2013 in “International journal of molecular sciences” Epidermal stem cells show promise for treating orthopedic injuries and diseases.
2 citations
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April 2021 in “bioRxiv (Cold Spring Harbor Laboratory)” The conclusion is that analyzing RNA from skin oils is a promising way to understand skin diseases.
1 citations
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April 2024 in “Cells” Corneal cells can potentially revert to stem cells, aiding in repair and regeneration.
1 citations
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December 2022 in “Frontiers in Immunology” Tissue environment greatly affects the unique epigenetic makeup of regulatory T cells, which could impact autoimmune disease treatment.
1 citations
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March 2022 in “IntechOpen eBooks” Aging reduces skin stem cell function, leading to changes like hair loss and slower wound healing.
1 citations
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November 2014 in “Elsevier eBooks” Future research should focus on making bioengineered skin that completely restores all skin functions.
February 2026 in “Biochemical and Biophysical Research Communications” Scientists successfully regenerated functional hair follicles using specific stem cells and mesenchymal cells.
September 2023 in “Nature Communications” Immune cells are essential for skin regeneration using biomaterial scaffolds.
January 2016 in “Springer eBooks” New materials and methods could improve skin healing and reduce scarring.
November 2022 in “Regenerative Therapy” Advancements in tissue engineering show promise for hair follicle regeneration to treat hair loss.
49 citations
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August 2022 in “Frontiers in Immunology” Psoriasis involves an imbalance between certain immune cells, and targeting these could help restore skin health.
4 citations
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August 2025 in “Frontiers in Immunology” Mesenchymal stem cells and their vesicles may effectively treat skin diseases, but more research is needed.
124 citations
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June 2020 in “Cell Stem Cell” Fat cells in the skin help start healing and form important repair cells after injury.
41 citations
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June 2013 in “PLOS ONE” Engineered skin substitutes can grow hair but have limitations like missing sebaceous glands and hair not breaking through the skin naturally.
610 citations
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April 2014 in “Nature Reviews Immunology” The document concludes that understanding how the skin's immune system and inflammation work is complex and requires more research to improve treatments for skin diseases.
40 citations
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January 2016 in “Elsevier eBooks” The skin is the largest organ, protecting the body, regulating temperature, and producing hormones.
27 citations
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July 2017 in “Scientific Reports” N-WASP is essential for healthy skin and preventing inflammation.
15 citations
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August 2022 in “Journal of endocrinological investigation” Vitamin D and calcium are important for quick and effective skin wound healing.
March 2026 in “Frontiers in Medicine” Different types of alopecia cause hair loss due to immune system issues, with some allowing regrowth and others causing permanent loss.
August 2024 in “Receptors” Vitamin D receptor is crucial for skin wound healing.
7 citations
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July 2024 in “Current Issues in Molecular Biology” Understanding skin stem cells and their regulation is key to improving skin healing and treating disorders.
479 citations
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June 2014 in “Science” Epithelial stem cells can adapt and help in tissue repair and regeneration.
67 citations
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December 2019 in “PloS one” Beta-caryophyllene helps improve wound healing in mice, especially in females.