694 citations
,
April 2000 in “Nature genetics” Msx2 deficiency in mice leads to bone growth and organ development problems.
3 citations
,
March 2013 in “American Journal of Dermatopathology” Ossification in trichilemmal cysts is more common than previously believed.
7 citations
,
March 2002 in “AIDS” Indinavir, especially with vitamin A, may cause bone changes, but switching to nelfinavir can reduce these effects.
April 2012 in “Cancer Research” Bone marrow-derived cells can lead to skin inflammation and tumors in mice.
478 citations
,
September 1996 in “Proceedings of the National Academy of Sciences” Overexpression of PTHrP in chondrocytes causes short-limbed dwarfism and delayed bone formation in mice.
21 citations
,
September 2003 in “Journal of Clinical Investigation” Overexpressing noggin in mice causes severe osteoporosis.
160 citations
,
January 2017 in “Development” Blood vessels and specific genes help turn cartilage into bone when bones heal.
25 citations
,
May 2016 in “Progress in Biophysics & Molecular Biology” R-spondins and their receptors help increase bone growth and may be used to treat bone loss diseases.
22 citations
,
October 2011 in “Bone” Androgens affect bone and fat cell development differently based on the cells' embryonic origin.
41 citations
,
September 2010 in “Journal of dermatological science” Bone marrow and umbilical cord stem cells can help grow new hair.
36 citations
,
April 2013 in “Cell and Tissue Research” Bone-marrow and epidermal stem cells help heal wounds differently, with bone-marrow cells aiding in blood vessel formation and epidermal cells in hair growth.
2 citations
,
March 2014 in “The Egyptian Journal of Histology” Bone marrow-derived stem cells greatly improve skin wound healing in rats.
May 2022 in “Frontiers in Cell and Developmental Biology” miR-29a-5p prevents the formation of early hair structures by targeting a gene important for hair growth and is regulated by a complex network involving lncRNA627.1.
47 citations
,
May 2012 in “Wiley Interdisciplinary Reviews-Developmental Biology” The conclusion is that understanding how feathers and hairs pattern can help in developing hair regeneration treatments.
519 citations
,
February 2020 in “Inflammation and Regeneration” RANKL is crucial for bone health, immune function, and other body processes.
11 citations
,
December 2018 in “Bone” Removing a methyl group from the ITGAV gene speeds up bone formation in a specific type of bone disease model.
8 citations
,
May 2019 in “Journal of Stem Cells & Regenerative Medicine” Dental pulp stem cells are better for tissue repair, while fat tissue stem cells may be more suited for wound healing and hair growth.
7 citations
,
January 2023 in “Frontiers in Cell and Developmental Biology” Caspases are enzymes important for both cell death and various non-lethal cell functions, affecting head development and hair growth, with different caspases playing specific roles.
5 citations
,
January 2023 in “Cell proliferation” Chick embryo extract helps rat hair follicle stem cells potentially turn into Schwann cells, important for the nervous system.
2 citations
,
July 2019 in “Journal of lasers in medical sciences” Laser treatment and synovial fluid can change hair follicle cells to resemble joint cells, with the changes being more significant when both treatments are used together.
January 2022 in “Autopsy and Case Reports” A man had a non-cancerous neck tumor related to hair follicles removed with no return of the tumor.
PTHrP is important for bone formation and may be targeted for osteoporosis treatment and longevity therapies.
102 citations
,
April 2014 in “PloS one” Wharton’s Jelly stem cells from the umbilical cord improve skin healing and hair growth without scarring.
44 citations
,
June 2017 in “The EMBO Journal” LPA3 signaling in the uterus is crucial for placental formation and fetal development.
28 citations
,
April 2023 in “Stem cell research & therapy” Tiny vesicles from stem cells could be a new treatment for healing wounds.
18 citations
,
December 2009 in “Canadian Journal of Animal Science” The BMP2 gene is more active in the early growth phase of Cashmere goat hair and may affect hair regeneration and textile production.
March 2024 in “Biomedicines” Mesenchymal stem cells show promise for effective skin repair and regeneration.
Dermal papilla cells can help form hair-like structures in lab-grown skin cells.
111 citations
,
June 2002 in “The EMBO Journal” Too much Smad7 can cause serious changes in skin tissues, including problems with hair growth, thymus shrinkage, and eye development issues.
165 citations
,
December 2004 in “Differentiation” BMP signaling is crucial for skin and hair growth.