351 citations
,
February 2010 in “Nature Cell Biology” Basal cell carcinoma mostly starts from cells in the upper skin layers, not hair follicle stem cells.
98 citations
,
August 2007 in “PLoS ONE” Myc changes chromatin in stem cells, causing them to leave their niche.
85 citations
,
September 2013 in “International Journal of Molecular Sciences” Keratin 15 is not a reliable sole marker for identifying epidermal stem cells because it's found in various cell types.
29 citations
,
July 2014 in “PloS one” Meis1 is crucial for skin health and tumor development.
53 citations
,
June 2017 in “Skin appendage disorders” PRP treatment helps hair growth in most cases, but more research needed.
39 citations
,
January 2015 in “International journal for parasitology/International Journal for Parasitology” Epidermal keratinocytes start wound healing and inflammation after schistosome infection.
6 citations
,
September 2024 in “Frontiers in Physiology” Overexpression of R-spondin 3 leads to sparse hair and impaired hair regeneration.
1 citations
,
May 2020 in “Journal of The American Academy of Dermatology” Inflammation and fibrosis are important factors in hair loss, but more research with better control samples is needed.
Integrin alphavbeta6 is important for wound healing and hair growth, and blocking it may improve these processes.
10 citations
,
June 2014 in “Experimental Dermatology” Decorin, a protein, may help start hair growth and could be used to treat hair loss.
11 citations
,
August 2013 in “International Journal of Cosmetic Science” The study suggests that a new protease inhibitor can make hair harder to pull out, potentially reducing hair loss.
1010 citations
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August 2000 in “Cell” Hair follicle stem cells can form both hair follicles and skin.
27 citations
,
December 2002 in “Journal of dermatological science” Merkel cells and Langerhans cells in hair follicles are closely connected and may interact.
November 2025 in “Journal of Investigative Dermatology” Estetrol may help prevent hair loss and support hair growth in women.
February 2026 in “Biochemical and Biophysical Research Communications” Scientists successfully regenerated functional hair follicles using specific stem cells and mesenchymal cells.
321 citations
,
December 2009 in “Journal of Dermatological Science” Dermal cells are key in controlling hair growth and could potentially be used in hair loss treatments, but more research is needed to improve hair regeneration methods.
133 citations
,
March 1999 in “Journal of Cutaneous Pathology” Trichoepitheliomas and some basal cell carcinomas likely come from hair follicle stem cells.
80 citations
,
September 2007 in “Cell Cycle” Stem cells in hair follicles can become various cell types, including neurons.
65 citations
,
December 2000 in “PubMed” The biology of skin and hair is complex and not fully understood.
32 citations
,
August 2006 in “Archives of Dermatological Research” Dermal papilla cells can help regrow hair follicles.
31 citations
,
January 2009 in “Autoimmunity Reviews” Damage to hair follicle stem cells causes permanent hair loss and scarring in cutaneous lupus erythematosus.
10 citations
,
June 2016 in “Cell Transplantation” Sebaceous glands can help harvest hair follicle stem cells to regenerate skin and hair.
6 citations
,
July 2009 in “Journal of Cutaneous Pathology” Hair follicle stem cells are key for hair growth and skin repair.
1 citations
,
January 2020 in “PubMed” Azelaic acid helps protect hair cells from UV damage and encourages hair growth by increasing certain gene expressions and proteins.
May 2018 in “International journal of cell science & molecular biology” Early anti-aging hair treatments should focus on anti-inflammatory agents and promoting healthy hair growth cycles.
Alopecia areata is reversible because hair follicles can regenerate due to stem cells.
46 citations
,
August 2006 in “Mechanisms of Development” Runx1 is crucial for proper hair structure and development.
July 2024 in “International Journal of Molecular Sciences” RF-based therapies might help treat hair loss.
54 citations
,
September 1999 in “PubMed” K15 staining helps distinguish basal cell carcinoma from trichoepithelioma.
51 citations
,
April 2013 in “Journal of Investigative Dermatology” Hair follicle stem cells rely on nearby blood vessels for their maintenance and function.