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Progesterone-Independent Neurosteroid Regulation of Alpha2-GABA-A Receptors in the Hippocampus Subfields

research PR-independent neurosteroid regulation of α2-GABA-A receptors in the hippocampus subfields

14 citations , March 2017 in “Brain research”

Progesterone and its byproducts control a specific receptor in the brain independently of progesterone receptors, affecting conditions related to the menstrual cycle.

research Control of hair growth and follicle size by VEGF-mediated angiogenesis

520 citations , February 2001 in “Journal of Clinical Investigation”

VEGF helps hair grow and determines follicle size by increasing blood vessel growth.

research Neurosteroidogenesis Is Required for the Physiological Response to Stress: Role of Neurosteroid-Sensitive GABA_AReceptors

248 citations , December 2011 in “Journal of Neuroscience”

Neurosteroids are crucial for stress response, and targeting specific receptors may help treat certain disorders.

research Hair follicle aging is driven by transepidermal elimination of stem cells via COL17A1 proteolysis

242 citations , February 2016 in “Science”

Hair loss and aging are caused by the breakdown of a key protein in hair stem cells.

research Timing of expression of the core clock gene Bmal1 influences its effects on aging and survival

237 citations , February 2016 in “Science Translational Medicine”

The timing of when the gene Bmal1 is active affects aging and survival, with its absence during development, not adulthood, leading to premature aging.

research Expression Profiling and Cellular Localization of Genes Associated with the Hair Cycle Induced by Wax Depilation

27 citations , August 2005 in “The journal of investigative dermatology/Journal of investigative dermatology”

Researchers found new genes involved in hair growth, which could help develop new hair treatments.

research Effects of Imiquimod on Hair Follicle Stem Cells and Hair Cycle Progression

25 citations , July 2016 in “The journal of investigative dermatology/Journal of investigative dermatology”

Imiquimod cream activates hair follicle stem cells and causes early hair growth by changing immune cells and certain protein expressions.

research Wnt1a maintains characteristics of dermal papilla cells that induce mouse hair regeneration in a 3D preculture system

23 citations , June 2015 in “Journal of Tissue Engineering and Regenerative Medicine”

Wnt1a helps keep cells that can grow hair effective for potential hair loss treatments.

Poly(γ-Glutamic Acid)/Chitosan Hydrogel Nanoparticles for Effective Preservation and Delivery of Fermented Herbal Extract for Enlarging Hair Bulb and Enhancing Hair Growth

research
Poly(γ-Glutamic Acid)/Chitosan Hydrogel Nanoparticles For Effective Preservation And Delivery Of Fermented Herbal Extract For Enlarging Hair Bulb And Enhancing Hair Growth

22 citations , October 2019 in “International Journal of Nanomedicine”

The nanoparticles improved hair growth and enlarged hair bulbs.

research The Transmembrane Serine Protease HAT-like 4 Is Important for Epidermal Barrier Function to Prevent Body Fluid Loss

19 citations , March 2017 in “Scientific Reports”

HAT-L4 is crucial for preventing body fluid loss by maintaining skin barrier integrity.

research Estrogen modulates mesenchymal-epidermal interactions in the adult nipple

4 citations , March 2017 in “Development”

Estrogen is important for keeping adult mouse nipple skin healthy by controlling certain cell signals.

research p53‐dependent transcriptional regulation of EDA2R and its involvement in chemotherapy‐induced hair loss

37 citations , April 2010 in “FEBS Letters”

The study concludes that the EDA2R gene is activated by p53 during chemotherapy but is not necessary for chemotherapy-induced hair loss.

research Highly Upregulated Lhx2 in the Foxn1−/− Nude Mouse Phenotype Reflects a Dysregulated and Expanded Epidermal Stem Cell Niche

6 citations , May 2013 in “PloS one”

The Foxn1(-/-) nude mouse shows disrupted and expanded skin stem cell areas due to high Lhx2 levels.

research HDAC6-dependent deacetylation of NGF dictates its ubiquitination and maintains primordial follicle dormancy

January 2024 in “Theranostics”

HDAC6 helps keep ovarian follicles dormant, extending female fertility.

The Dihydrotestosterone Hypothesis of Prostate Cancer and Its Therapeutic Implications

research The dihydrotestosterone (DHT) hypothesis of prostate cancer and its therapeutic implications

57 citations , January 1986 in “The Prostate”

The document suggests that targeting the hormone DHT could be a more effective treatment for prostate cancer than targeting testosterone.

research Alopecia - the search for novel agents continues

11 citations , August 1997 in “Expert Opinion on Therapeutic Patents”

Many potential alopecia treatments need more testing to confirm they promote acceptable hair growth with minimal side effects.

research Analysis of androgen receptor expression and activity in the mouse brain

May 2024 in “Scientific Reports”

Androgen receptors in the mouse brain may explain cognitive and mood changes in prostate cancer treatment.

Overview of Hair Biology, Research Models, and Evaluation of Hair Regrowth Potential In Vitro and In Vivo

research TỔNG QUAN VỀ SINH HỌC CỦA TÓC, MÔ HÌNH NGHIÊN CỨU VÀ ĐÁNH GIÁ KHẢ NĂNG MỌC LẠI TÓC TRÊN IN-VITRO VÀ IN-VIVO

May 2024 in “Tạp chí Y Dược học Cần Thơ”

Natural remedies like grapefruit and rosemary may help hair regrowth.

research Long-term time-lapse multimodal intravital imaging of regeneration and bone-marrow-derived cell dynamics in skin

18 citations , September 2013 in “Technology”

The study introduced a new imaging technology to track skin healing and bone marrow cell activity over time.

research Single-cell analysis reveals fibroblast heterogeneity and myeloid-derived adipocyte progenitors in murine skin wounds

301 citations , February 2019 in “Nature Communications”

The research found that different types of fibroblasts are involved in wound healing and that some blood cells can turn into fat cells during this process.

research Beta-caryophyllene enhances wound healing through multiple routes

67 citations , December 2019 in “PloS one”

Beta-caryophyllene helps improve wound healing in mice, especially in females.

research Gender-Difference in Hair Length as Revealed by Crispr-Based Production of Long-Haired Mice with Dysfunctional FGF5 Mutations

6 citations , October 2022 in “International Journal of Molecular Sciences”

Male mice with FGF5 mutations grow longer hair than females.

research Activated Polyamine Catabolism Depletes Acetyl-CoA Pools and Suppresses Prostate Tumor Growth in TRAMP Mice

91 citations , July 2004 in “Journal of Biological Chemistry”

Overexpressing SSAT enzyme reduces prostate tumor growth in mice.

Activation of Beta-Catenin Signaling in CD133-Positive Dermal Papilla Cells Drives Postnatal Hair Growth

research Activation of β-Catenin Signaling in CD133-Positive Dermal Papilla Cells Drives Postnatal Hair Growth

26 citations , July 2016 in “PLOS ONE”

Activating β-catenin in certain skin cells speeds up hair growth in mice.

research Homozygous whole body Cbs knockout in adult mice features minimal pathology during ageing despite severe homocysteinemia

7 citations , March 2022 in “The FASEB journal”

Adult mice with CBS deficiency show minimal health issues and normal lifespan despite high homocysteine levels.

research Hypomorphic mutation in the hairless gene accelerates pruritic atopic skin caused by feeding a special diet to mice

3 citations , March 2016 in “Experimental Dermatology”

A mutation in the hairless gene speeds up severe itchy skin in mice on a special diet.

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