137 citations
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September 2005 in “Proceedings of the National Academy of Sciences of the United States of America” The HR protein helps hair grow by blocking a hair growth inhibitor, aiding in hair follicle regeneration.
133 citations
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February 2019 in “PLoS Biology” Feather patterns in birds are shaped by signaling interactions and cell movements, with EDA/EDAR crucial for pattern formation.
127 citations
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December 2005 in “Experimental Dermatology” Stress can stop hair growth in mice, and treatments can reverse this effect.
121 citations
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May 2009 in “Journal of Ethnopharmacology” Eclipta alba extract may help hair grow similarly to Minoxidil.
115 citations
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November 2004 in “Brain Behavior and Immunity” Stress increases nerve fibers and immune cell activity in mouse skin, possibly worsening skin conditions.
103 citations
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March 2011 in “PLoS Biology” Birds can lose neck feathers due to a genetic change that increases a gene's activity, helping them adapt to heat.
102 citations
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August 2008 in “Genes & Development” Laminin-511 is crucial for early hair growth and maintaining important hair development signals.
95 citations
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February 2019 in “The New England Journal of Medicine” Mutations in the PADI3 gene are linked to a higher risk of scarring hair loss in women of African descent.
93 citations
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April 2003 in “Proceedings of the National Academy of Sciences of the United States of America” Fatty acid transport protein 4 is essential for skin and hair development.
87 citations
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September 2019 in “Nature Communications” SOX11 and SOX4 help skin cells act like embryonic cells to heal wounds in mice.
75 citations
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October 2010 in “Mammalian genome” Sphynx cats are hairless and Devon Rex cats have curly hair due to specific genetic mutations.
74 citations
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January 2013 in “Journal of Investigative Dermatology” Four genetic risk spots found for hair loss, with WNT signaling involved and a link to curly hair.
64 citations
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March 2017 in “Nature communications” Researchers found 63 genes linked to male-pattern baldness, which could help in understanding its biology and developing new treatments.
64 citations
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March 2005 in “Journal of Investigative Dermatology” Brain-Derived Neurotrophic Factor (BDNF) slows down hair growth and promotes hair follicle regression.
57 citations
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December 2021 in “Nature Communications” Non-canonical Wnt signaling helps intestinal stem cells move to injury sites for tissue repair.
55 citations
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November 2018 in “American journal of human genetics” Mutations in the LSS gene cause a rare type of hereditary hair loss.
53 citations
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June 2017 in “Skin appendage disorders” PRP treatment helps hair growth in most cases, but more research needed.
53 citations
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January 2011 in “Diabetes” People with PCNT mutations often develop severe insulin resistance and early-onset diabetes during childhood or adolescence.
52 citations
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October 1999 in “Developmental Dynamics” Mutations in the hairless gene in mice affect its expression and lead to a range of developmental issues in multiple tissues.
47 citations
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November 2012 in “Wound repair and regeneration” Nude mice with grafted human skin developed scars similar to human hypertrophic scars.
45 citations
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January 2012 in “The Journal of Steroid Biochemistry and Molecular Biology” Too much AKR1C3 enzyme causes resistance to finasteride by increasing testosterone.
43 citations
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January 2011 in “Plastic and Reconstructive Surgery” Stem cells have great potential for improving wound healing, but more research is needed to find the best types and ways to use them.
42 citations
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March 2010 in “Endocrinology” Mice with human gene experienced hair loss when treated with DHT.
42 citations
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March 2008 in “Molecular and Cellular Endocrinology” Hormones and neuroendocrine factors control hair growth and color, and more research could lead to new hair treatment options.
38 citations
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October 2014 in “British journal of dermatology/British journal of dermatology, Supplement” Bimatoprost solution is effective and safe for long-term use in treating eyelash thinning.
36 citations
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March 2011 in “Nature Communications” Cells from a skin condition can create new hair follicles and similar growths in mice, and a specific treatment can reduce these effects.
35 citations
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October 2017 in “Signal Transduction and Targeted Therapy” Fibromodulin treatment helps reduce scarring and improves wound healing by making it more like fetal healing.
35 citations
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August 2010 in “The American journal of pathology” Researchers created a new mouse model for studying Citrullinemia Type I and similar conditions, showing symptoms and treatment responses like those in humans.
33 citations
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September 2012 in “Wound Repair and Regeneration” Applying calreticulin can speed up wound healing in diabetics.
32 citations
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February 1998 in “The journal of investigative dermatology/Journal of investigative dermatology” Two specific hair keratin genes are active during hair growth and decline as hair transitions to rest.