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Epidermal Cells Expressing Putative Cell Markers in Nonglabrous Skin Near the Distal End of the Arrector Pili Muscle

research Epidermal Cells Expressing Putative Cell Markers in Nonglabrous Skin Existing in Direct Proximity with the Distal End of the Arrector Pili Muscle

5 citations , January 2016 in “Stem Cells International”

Certain skin cells near the base of hair muscles may help renew and stabilize skin, possibly affecting skin disorder understanding.

CPK1 Activates CNGCs Through Phosphorylation for Calcium Signaling to Promote Root Hair Growth in Arabidopsis

research CPK1 activates CNGCs through phosphorylation for Ca2+ signaling to promote root hair growth in Arabidopsis

January 2025 in “Nature Communications”

CPK1 helps root hair growth in Arabidopsis by activating channels for calcium signaling.

Involucrin, But Not Filaggrin and Kdap mRNA, Expression Is Downregulated in 3-D Cultures of Intact Rat Hair Bulbs After Calcium Stimulation

research Involucrin, but not filaggrin and Kdap mRNA, expression is downregulated in 3-D cultures of intact rat hair bulbs after calcium stimulation

3 citations , July 2011 in “Folia Histochemica et Cytobiologica”

Calcium reduces involucrin in rat hair bulbs but doesn't affect filaggrin and Kdap.

research Prediction of cell states and key transcription factors of the human cornea through integrated single-cell omics analyses

July 2025 in “PNAS Nexus”

A new tool accurately identifies human cornea cell states and key factors.

research Lysine Carboxymethyl Cysteinate (LCC) Protects the Epidermis from UVB-Induced Barrier Damage Through the Activation of Autophagy

April 2026 in “Biology”

Lysine carboxymethyl cysteinate (LCC) has been shown to protect the epidermis from UVB-induced damage by activating autophagy. In a study using a 3D living skin equivalent model, LCC restored epidermal cell thickness by 9.67% and significantly increased the expression of biomarkers related to skin hydration and cornified envelope formation. Transcriptomics analysis in human keratinocytes revealed that LCC influences glutathione synthesis, oxidation response, inflammation, and autophagy. The protective effects of LCC, particularly in barrier formation and autophagy, were confirmed and shown to be negated by chloroquine, an autophagy inhibitor. These findings highlight LCC's potential in safeguarding skin integrity against UVB damage.

research Manipulation of stem cell proliferation and lineage commitment:visualisation of label-retaining cells in wholemounts of mouse epidermis

421 citations , September 2003 in “Development”

Stem cell behavior varies with stimuli, and lineage changes can happen without affecting stem cell division.

research DataSheet1.zip

December 2021

GPC1 is important for hair growth by helping blood vessels form around hair follicles.

research Immunologic findings in central centrifugal cicatricial alopecia

1 citations , July 2012 in “Nasza Dermatologia Online”

CCCA may be caused by both hair traction and an immune response.

research Investigation of the hair follicle inner root sheath in scarring and non‐scarring alopecia

28 citations , June 2007 in “Journal of Cutaneous Pathology”

IRS premature desquamation is not unique to CCCA and occurs in various scarring alopecias.

research The RAIG Family Member, GPRC5D, Is Associated with Hard-Keratinized Structures

64 citations , March 2004 in “The journal of investigative dermatology/Journal of investigative dermatology”

GPRC5D is linked to the formation of hair, nails, and certain tongue areas.

research Isolation and Characterization of a Novel Hair Follicle–Specific Gene, Hacl-1

25 citations , May 1994 in “Journal of Investigative Dermatology”

Researchers found a new gene, hacl-1, that is active in mouse hair follicles during hair growth and may be important for hair biology.

research Immunohistochemical demonstration of keratins in the epidermal layers of the Malayan pangolin (Manis javanica), with remarks on the evolution of the integumental scale armour

28 citations , September 2013 in “European Journal of Histochemistry”

Keratins in Malayan pangolins vary by region, suggesting scales evolved from the tail towards the head.

research Role of alkaline ceramidase 1 (Acer1) in regulating epidermal homeostasis and tumorigenesis

August 2017 in “Academic Commons (Stony Brook University)”

Acer1 is essential for skin health and affects hair growth and skin cancer risk.

research Thy1 marks a distinct population of slow-cycling stem cells in the mouse epidermis

7 citations , August 2022 in “Nature communications”

A specific group of slow-growing stem cells marked by Thy1 is crucial for skin maintenance and healing in mice.

research Tight Junction barriers in human hair follicles – role of claudin-1

39 citations , August 2018 in “Scientific reports”

Claudin-1 is important for the barrier function and growth of hair.

research Keratin expression by corneal and limbal stem cells during development

25 citations , August 2020 in “Experimental eye research/Experimental Eye Research”

Different types of cells in the eye express specific keratins at various stages of development.

research Deletion of the epidermis derived laminin γ1 chain leads to defects in the regulation of late hair morphogenesis

19 citations , May 2016 in “Matrix Biology”

Deleting a specific protein in skin cells disrupts normal hair growth and development.

research Cornification in reptilian epidermis occurs through the deposition of keratin‐associated beta‐proteins (beta‐keratins) onto a scaffold of intermediate filament keratins

33 citations , October 2012 in “Journal of Morphology”

Reptile skin hardens by layering beta-proteins on keratin.

research Immunohistochemical localization of cytokeratins and involucrin in calcifying epithelioma: comparative studies with normal skin

49 citations , July 2006 in “British Journal of Dermatology”

Calcifying epithelioma cells can differentiate into hair cortex and outer root sheath.

research 863 Central centrifugal cicatricial alopecia gene expression analysis revealed cholesterol, fatty acid, and mast cell pathways

April 2019 in “The journal of investigative dermatology/Journal of investigative dermatology”

Targeting cholesterol, fatty acids, fibrosis, and mast cells may help treat CCCA.

research K25 (K25irs1), K26 (K25irs2), K27 (K25irs3), and K28 (K25irs4) Represent the Type I Inner Root Sheath Keratins of the Human Hair Follicle

93 citations , July 2006 in “Journal of Investigative Dermatology”

K25, K27, and K28 are found in all inner root sheath layers of hair, while K26 is only in the cuticle.

research Follicle-innervating Aδ-low threshold mechanoreceptors organize through a population-dependent mechanism

August 2022 in “bioRxiv (Cold Spring Harbor Laboratory)”

Mouse touch-sensitive nerve cells adjust their connections based on competition with other similar cells.

research Store-operated calcium channels in skin

6 citations , October 2022 in “Frontiers in Physiology”

Calcium channels are vital for normal skin function and their dysfunction can lead to skin issues.

research KCNQ4 K+ channels tune mechanoreceptors for normal touch sensation in mouse and man

109 citations , November 2011 in “Nature Neuroscience”

research Intravital Two-Photon Imaging of Touch Sensory Axon Morphology in Mouse Skin

September 2025

A new imaging method helps see and study touch nerve endings in mouse skin.

research Immunolocalization of junctional proteins in human hairs indicates that the membrane complex stabilizes the inner root sheath while desmosomes contact the companion layer through specific keratins

12 citations , January 2013 in “Acta Histochemica”

Junctional proteins stabilize the inner root sheath and connect the companion layer in human hair.

CD201+ Fascia Progenitors Choreograph Injury Repair

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