May 2026 in “Jurnal Riset Kefarmasian Indonesia” Robusta coffee beans have high caffeine content, useful for products like hair growth stimulants.
January 2026 in “AAPS PharmSciTech” Liposomal formulations with caffeine and cafestol enhance skin penetration effectively.
January 2026 in “British Journal of Dermatology” Caffeine and DMG increase calcium influx in hair follicle cells without being toxic.
TrichoSol™ effectively stabilizes various hair treatment ingredients for different durations.
TrichoFoam™ is a stable option for personalized hair loss treatment with most ingredients remaining effective for 90-180 days.
January 2024 in “Indonesian Journal of Pharmaceutical Education” The Caffein Herbasome® cream is stable and suitable for skin use.
Red clover and caffeine both promote hair growth, but combining them doesn't enhance the effect.
September 2023 in “Journal of The American Academy of Dermatology” Caffeine may help hair grow better.
July 2022 in “International Journal of Applied Pharmaceutics” The optimized caffeine formula improved hair growth and penetrated all skin layers.
January 2022 in “DOAJ (DOAJ: Directory of Open Access Journals)” Argan oil-based nano carriers could potentially deliver caffeine to hair follicles to treat hair loss.
November 2021 in “Research Square (Research Square)” The new caffeine cream works better for hair growth than existing products.
December 2020 in “Journal of Cosmetic Science” The caffeine content in anticellulite gels is 0.7-1.7% and in hair-care products is about 1.0%.
The optimal concentration for caffeine release in gel form is 0.2% caffeine and 2.3% chitosan.
Nanoparticles with caffeine can be used for slow, continuous hair growth stimulation.
May 2025 in “International Journal of Innovative Technologies in Social Science” Caffeine causes sleep problems in many medical students.
Caffeine can potentially treat common hair loss by counteracting hair follicle shrinkage caused by hormones.
The caffeine shampoo for hair loss is stable and suitable for use.
5 citations
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October 2020 in “Giornale italiano di dermatologia e venereologia” The phyto-caffeine shampoo reduced hair loss and improved hair strength in women with hair thinning.
55 citations
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March 2005 in “Neuropharmacology” A neurosteroid can reduce caffeine-induced anxiety in rats.
94 citations
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May 2011 in “BJCP. British journal of clinical pharmacology/British journal of clinical pharmacology” Hair follicles greatly increase caffeine absorption through the skin shortly after it's applied.
61 citations
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January 2018 in “Cosmetics” Coffee silverskin may be a beneficial and safe ingredient for cosmetics, offering hydration, firmness, and potential hair growth benefits.
42 citations
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July 2014 in “European journal of pharmaceutics and biopharmaceutics” Caffeine nanocrystals for skin products stay stable with the right stabilizer, but grow in size at higher temperatures.
9 citations
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July 2014 in “PubMed” The review doesn't clearly say if biotin, caffeine, melatonin, a marine extract, and zinc are effective for treating hair loss.
2 citations
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January 2022 in “Dermatologic Therapy” Natural products like saw palmetto, caffeine, melatonin, marine extracts, rosemary oil, procyanidin, pumpkin seed oil, and cannabidiol oil could potentially treat male hair loss.
2 citations
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January 2016 Optimized formulations with specific ingredients can significantly improve skin delivery of topical drugs.
2 citations
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January 2014 Improved methods create smaller, more effective gelatin nanoparticles for skin delivery, and new caffeine nanocrystals enhance absorption and effectiveness.
1 citations
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July 2021 in “Chemical & pharmaceutical bulletin/Chemical and pharmaceutical bulletin” Rubbing skin increases absorption of water-soluble drugs from lotions and creams, but not oil-soluble drugs.
1 citations
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January 2019 in “Advances in Medical Sciences” The combination of azelaic acid, minoxidil, and caffeine significantly increased the survival of skin flaps by affecting certain body channels and nitric oxide levels.
1 citations
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March 2018 in “Dermatologie pro praxi” Most over-the-counter hair loss treatments lack strong evidence of effectiveness, except for minoxidil, which works but stops working if you stop using it.