May 2025 in “International Journal of Innovative Technologies in Social Science” Caffeine causes sleep problems in many medical students.
December 2022 in “Clinical and experimental dermatology and therapies” Adding the topical gel improved hair growth more than using minoxidil or finasteride alone.
55 citations
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March 2005 in “Neuropharmacology” A neurosteroid can reduce caffeine-induced anxiety in rats.
94 citations
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May 2011 in “BJCP. British journal of clinical pharmacology/British journal of clinical pharmacology” Hair follicles greatly increase caffeine absorption through the skin shortly after it's applied.
42 citations
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July 2014 in “European journal of pharmaceutics and biopharmaceutics” Caffeine nanocrystals for skin products stay stable with the right stabilizer, but grow in size at higher temperatures.
12 citations
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March 2012 in “ATLA. Alternatives to laboratory animals” Hair follicles significantly affect the skin absorption of some drugs.
9 citations
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July 2014 in “PubMed” The review doesn't clearly say if biotin, caffeine, melatonin, a marine extract, and zinc are effective for treating hair loss.
7 citations
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February 2018 in “International Journal of Pharmaceutics” Researchers developed a method to measure drugs in hair follicles and found that both water-loving and fat-loving drugs can be detected after being applied to the skin.
5 citations
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September 2023 in “International Journal of Molecular Sciences” FucoPol hydrogel membranes are promising for delivering drugs on the skin.
4 citations
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July 2023 in “Pharmaceutics (Basel)” Nanoparticle-based drug delivery to hair follicles is more effective when tested under conditions that match skin behavior.
3 citations
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January 2023 in “International Journal of Cosmetic Science” Coffee and its by-products are promising for skin health benefits in cosmetics and help reduce environmental impact.
2 citations
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January 2022 in “Dermatologic Therapy” Natural products like saw palmetto, caffeine, melatonin, marine extracts, rosemary oil, procyanidin, pumpkin seed oil, and cannabidiol oil could potentially treat male hair loss.
2 citations
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July 2021 in “Dermatologic Therapy” A woman's hair loss after COVID-19 was likely due to a mix of pressure-induced alopecia and acute telogen effluvium.
2 citations
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August 2020 in “Chemical and Pharmaceutical Bulletin” Rubbing increases drug absorption through hair follicles.
2 citations
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January 2016 Optimized formulations with specific ingredients can significantly improve skin delivery of topical drugs.
2 citations
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January 2014 Improved methods create smaller, more effective gelatin nanoparticles for skin delivery, and new caffeine nanocrystals enhance absorption and effectiveness.
1 citations
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March 2022 in “Protection convergence” Fermented green coffee beans may be good for scalp and hair health cosmetics.
1 citations
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July 2021 in “Chemical & pharmaceutical bulletin/Chemical and pharmaceutical bulletin” Rubbing skin increases absorption of water-soluble drugs from lotions and creams, but not oil-soluble drugs.
1 citations
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January 2019 in “Advances in Medical Sciences” The combination of azelaic acid, minoxidil, and caffeine significantly increased the survival of skin flaps by affecting certain body channels and nitric oxide levels.
1 citations
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February 2025 in “Supportive Care in Cancer” Safe treatments like minoxidil and spironolactone can help manage hair loss in breast cancer patients without increasing cancer risk.
April 2026 in “Zenodo (CERN European Organization for Nuclear Research)” The serum promotes thicker, stronger, and healthier hair.
January 2026 in “Current Drug Research Reviews” Natural remedies like caffeine, capsaicin, and essential oils are effective and safer for hair growth.
October 2025 in “Food science and nutrition” Coffee has evolved into a cultural symbol influenced by science, health, and global trends.
September 2025 in “medRxiv (Cold Spring Harbor Laboratory)” Using Centella asiatica EV and growth factors improves scalp health and hair growth.
The TrichoConcept™ line is effective for personalized hair loss treatments.
December 2024 in “NATIONS UNIVERSITY INTERNATIONAL JOURNAL OF MULTI-DISCIPLINARY STUDIES” Natural substances like caffeine and rosemary oil may help hair growth, but more research is needed.
Arabica coffee pulp extract may help prevent hair loss and promote hair growth.
September 2023 in “Authorea (Authorea)” Certain peptides, caffeine, taurine, and an iron complex may improve hair regrowth when used with minoxidil and finasteride for hair loss.
June 2023 in “Journal of Pharmaceutical and Health Research” Caffeine hair tonic with 0.001% concentration was more effective in promoting hair growth on guinea pigs.