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research In vitro and in vivo study of dye diffusion into the human skin and hair follicles

69 citations , January 2002 in “Journal of biomedical optics”

Dyes can penetrate human skin and hair follicles up to 1.2 mm deep and the sebaceous gland can store dye; Indocyanine Green lotion was made for safe dyeing and monitoring.

research 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) Affects Keratin 1 and Keratin 17 Gene Expression and Differentially Induces Keratinization in Hairless Mouse Skin

45 citations , March 1997 in “Journal of Investigative Dermatology”

research Metabolite screening of aromatic amine hair dyes usingin vitrohepatic models

16 citations , October 2009 in “Xenobiotica”

The tested hair dye ingredients do not form harmful oxidized metabolites in the liver.

research Toxicity of Chlorinated Aromatic Compounds in Animals and Humans: In Vitro Approaches to Toxic Mechanisms and Risk Assessment

2 citations , May 1985 in “Environmental Health Perspectives”

Chlorinated compounds like TCDD can cause skin issues and chloracne by affecting cell behavior.

research Long-term toxicologic and tumorigenesis studies on an oral contraceptive agent in albino rats

61 citations , January 1970 in “Toxicology and Applied Pharmacology”

research Percutaneous penetration of hair dyes

66 citations , February 1985 in “Archives of dermatological research”

Hair dyes penetrate the scalp very minimally, less than 1%.

research Validation of Replacement of the Synthetic Food Dye 'Sunset Yellow'-Induced Hepatotoxicity and Genotoxicity with the Nutraceutical 'Curcumin' in Mice

8 citations , January 2016

Curcumin can safely replace Sunset Yellow as a food colorant.

Gene Expression Profiling of Human Keratinocytes Exposed to the Hair-Dyeing Agent, m-Aminophenol

research Gene expression profiling of human keratinocytes exposed to the hair-dying agent, m-aminophenol

March 2013 in “Molecular & Cellular Toxicology/Molecular & cellular toxicology”

m-Aminophenol in hair dye can cause skin cell toxicity and stress responses.

research 129 Genetic transformation of keratoacanthoma-type cutaneous squamous cell carcinoma following intralesional chemotherapy

2 citations , April 2018 in “Journal of Investigative Dermatology”

Intralesional chemotherapy with 5-fluorouracil and methotrexate may worsen keratoacanthoma-type skin cancer in transplant patients.

research 55 cases of allergic reactions to hair dye: a descriptive, consumer complaint‐based study

98 citations , November 2002 in “Contact Dermatitis”

Many people had severe allergic reactions to a common hair dye ingredient, causing them to seek medical care and miss work.

research Enzymatic synthesis of biosafe hematoxylin dyes on hair: enhanced post-dyeing hair health and boosting color fastness

November 2025 in “International Journal of Biological Macromolecules”

This eco-friendly hair dye method improves hair health and color durability.

research A Definitive Role of Ornithine Decarboxylase in Photocarcinogenesis

67 citations , September 2001 in “American Journal Of Pathology”

Inhibiting ODC can prevent UV-induced skin cancer.

research Patch tests with commercial hair dye products in patients with allergic contact dermatitis to para-phenylenediamine

6 citations , January 2016 in “Indian Journal of Dermatology Venereology and Leprology”

Most hair dyes can cause allergic reactions, so test before use.

research Paraphenylenediamine hair dyeing nephropathy: a case report and review of literature

4 citations , January 2018 in “Urology & Nephrology Open Access Journal”

Hair dye chemicals can cause serious health problems, including kidney damage.

research Chemical Leukoderma from Hair Dye Containing para-Phenylenediamine

9 citations , July 2012 in “Dermatitis”

Hair dye with para-phenylenediamine can cause skin depigmentation.

research Alterations in the expression of specific epidermal keratin markers in the hairless mouse by the topical application of the tumor promoters 2,3,7,8-tetrachlorodibenzo-p-dioxin and the phorbol ester 12-O-tetradecanoylphorbol-13-acetate

12 citations , January 1987 in “Carcinogenesis”

TCDD changes skin cell growth and keratin production in mice.

research Nanoparticles in hair dyes

6 citations , January 2020 in “Elsevier eBooks”

Nanoparticles could make hair dyes safer by reducing harmful effects.

research A clinical evaluation of a permanent hair dye designed to reduce allergic contact dermatitis and hair damage

9 citations , July 2022 in “Journal of Cosmetic Dermatology”

The ammonia-free hair dye is safe and improves hair shine, color, moisture, porosity, and combability.

research Effects of cytokines, anti-cancer agents and cocarcinogen on DNA synthesis in hair bulb cells

6 citations , April 1993 in “Journal of Dermatological Science”

Certain substances can strongly inhibit DNA synthesis in hair cells.

research Inducible Cutaneous Inflammation Reveals a Protumorigenic Role for Keratinocyte CXCR2 in Skin Carcinogenesis

70 citations , December 2008 in “Cancer Research”

CXCR2 in skin cells promotes tumor growth.

research A NEW GENERATION OF MARKERS FOR CANCER DETECTION AND DRUG TRANSPORT

January 2024 in “Wiadomości Lekarskie”

New markers can detect tumors, aid drug delivery, and treat cancer effectively and safely.

research Alkylating Agents

November 2013

Alkylating agents can kill cancer cells but may cause skin and allergic reactions.

A Further Investigation of the Role of Skin Components in Chemical Carcinogenesis

research A Further Investigation of the Rôle of Skin Components in Chemical Carcinogenesis

17 citations , March 1955 in “British Journal of Cancer”

Skin components play a part in the development of cancer caused by chemicals.

Allergic Contact Dermatitis from Dyes in Wigs Following Diphenylcyclopropenone Treatment

research Allergic contact dermatitis from dyes in wigs following diphencyprone treatment

8 citations , September 2004 in “Contact dermatitis”

Avoiding dyed wigs and clothing improved severe allergic reactions in a woman treated with diphencyprone.

research Tumors Of The Pilosebaceous Unit Induced In The Rat By The Intravenous Administration Of 7, 12-Dimethylbenz[A]Anthracene

6 citations , March 1976 in “Journal of Investigative Dermatology”

research Tuning Scaffold Properties of New 1,4-Substituted Pyrrolo[3,2-c]quinoline Derivatives Endowed with Anticancer Potential, New Biological and In Silico Insights

December 2025 in “Biomolecules”

Compound 7p shows strong potential as an anticancer agent.

research Patterns of Sensitization and Cross-Reactivity in Hair Dye Allergy: An 18-Year Tertiary-Center Experience from Greece.

February 2026 in “PubMed”

Most hair dye allergies are caused by para-phenylenediamine (PPD), and safer hair dye options are needed.

research Steroidogenic Factor-1 Lineage Origin of Skin Lesions in Carney Complex Syndrome

3 citations , May 2022 in “The journal of investigative dermatology/Journal of investigative dermatology”

Skin lesions in Carney Complex are caused by a gene change in some skin cells that leads to increased pigmentation and may lead to tumors.

research Histological Study of the Damaging Effect Induced by Cyclophosphamide on Intestinal Mucosa of Adult Male Albino Rat

3 citations , January 2021 in “Minia Journal of Medical Research”

Cyclophosphamide severely damages the intestinal lining in rats.

research 2,3,7,8‐Tetrachlorodibenzo‐p‐dioxin causes an increase in protein kinases growth hepatic associated with epidermal factor receptor in the plasma membrane

60 citations , December 1988 in “Journal of Biochemical Toxicology”

TCDD reduces EGF receptors in the liver, affecting growth and development.

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