Search

for
Search:

Did you mean Caspase-1?

GlossaryCaspase-1

enzyme activating inflammatory cytokines and inducing cell death

Caspase-1, also known as Interleukin-1 converting enzyme (ICE), is an enzyme that plays a crucial role in the inflammatory response by activating pro-inflammatory cytokines like interleukin-1β (IL-1β) and interleukin-18 (IL-18). It is also involved in a form of programmed cell death called pyroptosis, which helps the body fight infections by eliminating infected cells.

Related Terms

Sort by

Research

30 / 1000+ results

research Expression of apoptosis-related genes in the mouse skin during the first postnatal catagen stage, focused on localization of Bnip3L and caspase-12

4 citations , June 2015 in “Connective tissue research”

The research found changes in gene expression related to cell death in mouse skin that help understand hair follicle development and skin health.

research The Inflammatory Caspases-1 and -11 Mediate the Pathogenesis of Dermatitis in Sharpin-Deficient Mice

59 citations , July 2015 in “Journal of Immunology”

Certain proteins, caspases-1 and -11, are important in the early development of skin inflammation in mice.

research Caspase-1 Level Is Higher in the Scalp in Androgenetic Alopecia

27 citations , March 2012 in “Dermatologic Surgery”

Higher caspase-1 levels found in balding scalps; reducing it may help treat hair loss.

12-O-Tetradecanoylphorbol-13-Acetate Induces Apoptosis in Renal Epithelial Cells Through a Growth Signal Conflict Prevented by Activated Ras

research 12-O-Tetradecanoylphorbol-13-acetate Induces Apoptosis in Renal Epithelial Cells through a Growth Signal Conflict Which Is Prevented by Activated ras1

4 citations , January 2001 in “Archives of Biochemistry and Biophysics”

Activated ras can protect kidney cells from a certain substance that causes cell death.

research 1117 PX-12 inhibits NLRP3 inflammasome activation to treat psoriasis

April 2023 in “Journal of Investigative Dermatology”

PX-12 may help treat psoriasis by blocking inflammation and cell death.

research Camellia sinensis Seed Flavonoids Attenuate UVB-Induced Inflammation and UVA-Induced Photodamage via MAPK/NF-κB and AP-1 Pathways

March 2026 in “Molecules”

Camellia sinensis seed flavonoids can reduce skin inflammation and damage from UV rays.

research Effects of Short-Term Finasteride on Apoptotic Factors and Androgen Receptors in Prostate Cancer Cells

25 citations , December 2008 in “The Journal of Urology”

Short-term finasteride treatment may lower some cell death factors in prostate cancer cells.

The Effect of JAK Inhibitor on Survival, Anagen Re-Entry, and Hair Follicle Immune Privilege Restoration in Human Dermal Papilla Cells

research The Effect of JAK Inhibitor on the Survival, Anagen Re-Entry, and Hair Follicle Immune Privilege Restoration in Human Dermal Papilla Cells

16 citations , July 2020 in “International Journal of Molecular Sciences”

Ruxolitinib may help treat hair loss by reducing inflammation, promoting hair growth signals, and protecting hair follicle immunity.

Umbilical Cord Mesenchymal Stem Cell-Derived Apoptotic Extracellular Vesicles Ameliorate Cutaneous Wound Healing in Type 2 Diabetic Mice via Macrophage Pyroptosis Inhibition

research Umbilical cord mesenchymal stem cell-derived apoptotic extracellular vesicles ameliorate cutaneous wound healing in type 2 diabetic mice via macrophage pyroptosis inhibition

4 citations , September 2023 in “Stem cell research & therapy”

Special particles from umbilical cord stem cells help heal skin wounds in diabetic mice by preventing certain immune cell death.

research Artificial Infestation of Sarcoptes scabiei (Acari: Sarcoptidae) in Rabbits Exhibits Progressive Pathological Changes, Apoptosis, and Keratinization in the Skin

1 citations , January 2023 in “International journal of molecular sciences”

Rabbits with Sarcoptes scabiei had thicker skin, cell death, and skin hardening.

Immunomodulatory Effects of Platelet-Rich Plasma on Neuroinflammation: Insights from BV2 Glial Cells Stimulated with Heat-Killed Escherichia Coli

research Immunomodulatory Effects of Platelet-Rich Plasma (PRP) on Neuroinflammation: Insights from B92 Glial Cells Stimulated with Heat-Killed Escherichia coli

November 2025

PRP may help reduce brain inflammation and protect brain cells.

Hair Follicle-Derived Mesenchymal Stem Cells Decrease Alopecia Areata Mouse Hair Loss and Reduce Inflammation Around the Hair Follicle

research Hair follicle-derived mesenchymal stem cells decrease alopecia areata mouse hair loss and reduce inflammation around the hair follicle

11 citations , October 2021 in “Stem Cell Research & Therapy”

Hair follicle stem cells reduced hair loss and inflammation in mice with a condition similar to human alopecia.

Complex Changes in the Apoptotic and Cell Differentiation Programs During Initiation of the Hair Follicle Response to Chemotherapy

research Complex Changes in the Apoptotic and Cell Differentiation Programs during Initiation of the Hair Follicle Response to Chemotherapy

12 citations , July 2014 in “Journal of Investigative Dermatology”

Chemotherapy causes complex changes in hair follicle cells that can lead to hair loss.

Non-Apoptotic Role for Caspase-7 in Hair Follicles and Surrounding Tissue

research Non-apoptotic role for caspase-7 in hair follicles and the surrounding tissue

6 citations , August 2015 in “Journal of Molecular Histology”

Caspase-7 has functions in skin and hair that are not related to cell death.

Melatonin Promotes Secondary Hair Follicle Development in Early Postnatal Cashmere Goats and Improves Cashmere Quantity and Quality by Enhancing Antioxidant Capacity and Suppressing Apoptosis

research Melatonin promotes secondary hair follicle development of early postnatal cashmere goat and improves cashmere quantity and quality by enhancing antioxidant capacity and suppressing apoptosis

46 citations , March 2019 in “Journal of Pineal Research”

Melatonin improves cashmere goat hair growth and quality by increasing antioxidants and reducing cell death.

research Central Centrifugal Cicatricial Alopecia Associated With PDL1 Loss and Increased Expression of Caspase 3: A Case Series

2 citations , April 2023 in “American Journal of Dermatopathology”

CCCA may involve the PD1/PDL1 pathway and increased caspase 3, leading to permanent hair loss.

research Bioinformatic network analysis on the molecular interactions between Parkinson’s disease, alpha-synuclein, and infertility condition

September 2023 in “Middle East Fertility Society Journal”

Nicotine may help treat both Parkinson's disease and infertility.

research The effect of tripeptide-copper complex on human hair growth in vitro

39 citations , July 2007 in “Archives of Pharmacal Research”

A tripeptide-copper complex may help hair grow by increasing cell growth and decreasing cell death.

research Stem cell apoptosis in HIV‐1 alopecia

15 citations , August 2006 in “Journal of Cutaneous Pathology”

HIV-1 may cause increased stem cell death in hair follicles, leading to hair loss.

research Tetrahydroxystilbene Glucoside Effectively Prevents Apoptosis Induced Hair Loss

9 citations , January 2018 in “BioMed Research International”

Tetrahydroxystilbene Glucoside may help prevent hair loss by blocking certain pathways that lead to cell death.

research Protection against oxidative damage and anti-inflammatory effect of melatonin in scald rat

January 2008

Melatonin reduced oxidative damage, inflammation, and protected hair cells in scalded rats.

research Effects of Finasteride on Apoptosis and Regulation of the Human Hair Cycle

21 citations , January 2002 in “Journal of Cutaneous Medicine and Surgery”

Finasteride affects hair growth by changing caspase and XIAP levels, potentially treating hair diseases.

research Apoptosis, Androgenetic Alopecia, and the Hair Cycle

January 2002 in “Hair transplant forum international”

Finasteride reduces hair follicle cell death in androgenetic alopecia.

research From stem cells protection to skin microbiota balance: Orobanche rapum extract, a new natural strategy

9 citations , November 2018 in “Journal of cosmetic dermatology”

Orobanche rapum extract rejuvenates skin and protects skin bacteria, leading to healthier skin.

research Effect of Liquid Blood Concentrates on Cell Proliferation and Cell Cycle- and Apoptosis-Related Gene Expressions in Nonmelanoma Skin Cancer Cells: A Comparative In Vitro Study

December 2024 in “International Journal of Molecular Sciences”

Platelet-rich fibrin may help reduce nonmelanoma skin cancer cell growth.

research A practical guide for the study of human and murine sebaceous glands in situ

56 citations , September 2013 in “Experimental Dermatology”

The guide explains how to study human and mouse sebaceous glands using various staining and imaging techniques, and emphasizes the need for standardized assessment methods.

research Inflammasome Proteins Are Reliable Biomarkers of the Inflammatory Response in Aneurysmal Subarachnoid Hemorrhage

4 citations , August 2024 in “Cells”

Inflammasome proteins can predict inflammation and outcomes in aneurysmal subarachnoid hemorrhage.

research Proof-of-Principle Study of Inflammasome Signaling Proteins as Diagnostic Biomarkers of the Inflammatory Response in Parkinson’s Disease

17 citations , June 2023 in “Pharmaceuticals”

Inflammasome proteins may help diagnose and treat Parkinson's disease.

Effect of Methanol Extract of Etlingera Alba (Blume) A. D. Poulsen Stems on Caspase-3 Gene Suppression as an Apoptosis Marker in T47D Breast Cancer Cell Line In Vitro

research Pengaruh Ekstrak Metanol Batang Etlingera alba (Blume) A. D. Poulsen Terhadap Penekanan Genicaspase-3 sebagai Penanda Apoptosis pada Lini Sel Kanker Payudara T47D Secara In Vitro

June 2025 in “Jurnal Mandala Pharmacon Indonesia”

Etlingera alba extract may help treat breast cancer with fewer side effects.

Forsythiaside A Protects Against Focal Cerebral Ischemic Injury by Mediating the Activation of the Nrf2 and Endoplasmic Reticulum Stress Pathways

research Forsythiaside A protects against focal cerebral ischemic injury by mediating the activation of the Nrf2 and endoplasmic reticulum stress pathways

12 citations , May 2019 in “Molecular Medicine Reports”

Forsythiaside A helps reduce brain damage from lack of blood flow by activating certain protective pathways.