30 citations
,
December 2017 in “Medical Hypotheses” The model suggests that scalp tension could lead to hair loss, with factors like blood vessel hardening, enlarged oil glands, and poor microcirculation also playing a role. It also hints at a possible link between skull shape and baldness pattern.
September 2004 in “Atlas of the Oral and Maxillofacial Surgery Clinics” Hair restoration surgery techniques can effectively treat scalp deformities and have evolved to provide natural-looking results.
25 citations
,
January 2018 in “Acta Clinica Croatica” Allogeneic platelet gel heals chronic wounds better than hydrogel.
166 citations
,
March 2007 in “Hypertension” High androgen levels in young women with PCOS are linked to higher blood pressure.
152 citations
,
December 2007 in “Gender Medicine” Male and female skin differ due to hormones, affecting conditions like hair loss, acne, and skin cancer, and suggesting a need for gender-specific treatments.
25 citations
,
November 2001 in “Kidney International” Male hormones worsen kidney transplant damage, but blocking them helps.
23 citations
,
January 2020 in “Frontiers in Pharmacology” Dihydrotestosterone affects hair growth by changing the Wnt/β-catenin pathway, with low levels helping and high levels hindering growth.
December 2020 in “Skin appendage disorders” Finasteride may effectively treat hair loss in Klinefelter Syndrome patients.
37 citations
,
May 1999 in “Australasian Journal of Dermatology” Early diagnosis and treatment are crucial for preventing permanent hair loss in various scalp conditions, and while new treatments are promising, more research is needed to evaluate their effectiveness.
May 2023 in “Bali Medical Journal” Higher sebum levels are linked to more severe male baldness.
402 citations
,
August 2011 in “Cancer research” Prostate cancer cells can make their own androgens to activate the androgen receptor, and treatments like abiraterone may increase this ability, suggesting new therapies should target the entire steroid-making pathway.
229 citations
,
August 2002 in “Experimental Gerontology” AGA causes hair loss by shrinking hair follicles due to DHT binding, and can be treated with finasteride and minoxidil.
157 citations
,
April 1994 in “Clinical endocrinology” Androgens can cause hair growth in some areas and hair loss on the scalp.
138 citations
,
May 2000 in “Maturitas” Estrogen replacement can improve skin health in menopausal women but doesn't reverse sun damage or prevent hair loss.
124 citations
,
July 2012 in “Archives of Dermatological Research” Targeting androgen receptors could be a promising way to treat skin disorders with fewer side effects.
110 citations
,
April 2002 in “The Journal of clinical endocrinology and metabolism/Journal of clinical endocrinology & metabolism” Dihydrotestosterone gel improved well-being and sexual function in older men without negatively affecting prostate health.
98 citations
,
April 1997 in “The Journal of Steroid Biochemistry and Molecular Biology” Finasteride effectively blocks rat enzymes, but with varying methods and strength.
75 citations
,
May 1986 in “Clinics in endocrinology and metabolism” Male hormones are important for hair and oil gland development and can cause conditions like excessive hair growth and acne.
42 citations
,
May 2003 in “Mini-reviews in Medicinal Chemistry” New steroidal compounds could be effective for treating conditions related to 5α-reductase enzyme activity.
38 citations
,
July 1989 in “Archives of dermatological research” Testosterone causes hair loss in AGA mice, which are good for testing baldness treatments, and both minoxidil and cyproterone acetate can prevent this hair loss.
35 citations
,
February 1994 in “Fundamental and applied toxicology” High doses of finasteride cause cell growth and tumors in mice.
34 citations
,
July 2020 in “Frontiers in immunology” Androgens may influence T cells, contributing to higher autoimmune liver disease risk in women.
29 citations
,
April 1995 in “Endocrinology” Finasteride doesn't affect bone density in male rats.
24 citations
,
January 2001 in “Dermatologic clinics” Hormonal therapy is a treatment option for acne, the only medical treatment for hirsutism, and the most promising for androgenetic alopecia.
22 citations
,
January 2001 in “Chemical & Pharmaceutical Bulletin” Some new progesterone derivatives are better at blocking testosterone conversion than a common drug.
21 citations
,
April 2011 in “Physiological Research” Normal levels of DHT can reduce belly fat and increase muscle, but too much can lead to hair loss, prostate issues, and possibly heart disease.
20 citations
,
March 2005 in “Current Medicinal Chemistry” New compounds show promise for treating hair loss, enlarged prostate, and prostate cancer, with some being more effective and having different side effects than current treatments.
20 citations
,
January 2003 in “Chemical and Pharmaceutical Bulletin” The new progesterone derivatives effectively inhibit 5α-reductase and bind to the androgen receptor.
18 citations
,
June 2009 in “Journal of Molecular Endocrinology” Finasteride exposure harms tadpole reproduction and hormone balance.
18 citations
,
November 2007 in “Annals of Surgery” Finasteride reduces inflammation and improves immune response after trauma by altering hormone levels.