344 citations
,
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288 citations
,
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277 citations
,
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151 citations
,
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133 citations
,
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128 citations
,
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126 citations
,
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119 citations
,
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115 citations
,
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111 citations
,
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105 citations
,
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101 citations
,
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101 citations
,
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98 citations
,
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91 citations
,
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91 citations
,
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90 citations
,
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75 citations
,
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75 citations
,
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69 citations
,
January 2021 in “Journal of Biological Chemistry” Plant-derived amino acids can help develop new antimicrobial drugs.
65 citations
,
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63 citations
,
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62 citations
,
December 2007 in “Journal of biological chemistry/The Journal of biological chemistry” A specific chemical change in the S100A3 protein leads to the formation of a four-part structure important for hair formation.
60 citations
,
July 2014 in “Autophagy” The protein FLCN is involved in cellular cleanup and is regulated by ULK1.
57 citations
,
January 2019 in “Stem Cell Research & Therapy” OCT4 helps hair stem cells renew and fight aging, potentially aiding hair regrowth.
56 citations
,
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56 citations
,
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55 citations
,
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53 citations
,
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53 citations
,
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